Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Sarah J, Childs"'
Autor:
Suchit Ahuja, Cynthia Adjekukor, Qing Li, Katrinka M Kocha, Nicole Rosin, Elodie Labit, Sarthak Sinha, Ankita Narang, Quan Long, Jeff Biernaskie, Peng Huang, Sarah J Childs
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002590 (2024)
Brain pericytes are one of the critical cell types that regulate endothelial barrier function and activity, thus ensuring adequate blood flow to the brain. The genetic pathways guiding undifferentiated cells into mature pericytes are not well underst
Externí odkaz:
https://doaj.org/article/f95a0821ffab4be49de28da144fa1730
Autor:
Danielle L Blackwell, Sherri D Fraser, Oana Caluseriu, Claudia Vivori, Amanda V Tyndall, Ryan E Lamont, Jillian S Parboosingh, A Micheil Innes, François P Bernier, Sarah J Childs
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 5 (2022)
AbstractMutations in RNA-binding proteins can lead to pleiotropic phenotypes including craniofacial, skeletal, limb, and neurological symptoms. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in nucleic acid binding, transcription, and
Externí odkaz:
https://doaj.org/article/366d8921841d47e799ad4eed47dc49fa
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009769 (2021)
Vessel growth integrates diverse extrinsic signals with intrinsic signaling cascades to coordinate cell migration and sprouting morphogenesis. The pro-angiogenic effects of Vascular Endothelial Growth Factor (VEGF) are carefully controlled during spr
Externí odkaz:
https://doaj.org/article/cd02e6b0683e443196d0ddc66ed48532
Autor:
Miriam Zink, Anne Seewald, Mareike Rohrbach, Andreas Brodehl, Daniel Liedtke, Tatjana Williams, Sarah J. Childs, Brenda Gerull
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9530 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease caused by heterozygous missense mutations within the gene encoding for the nuclear envelope protein transmembrane protein 43 (TMEM43). The disease is characterized by myocyte lo
Externí odkaz:
https://doaj.org/article/35d6def1145d4b15abc89c047ae62d2e
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008163 (2019)
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1. We show that loss of miR
Externí odkaz:
https://doaj.org/article/15c7cec7987b43b4ab5831bf2a8576a4
Autor:
Jae-Ryeon Ryu, Suchit Ahuja, Corey R. Arnold, Kyle G. Potts, Aniket Mishra, Qiong Yang, Muralidharan Sargurupremraj, Douglas J. Mahoney, Sudha Seshadri, Stéphanie Debette, Sarah J. Childs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2022, 119 (35), ⟨10.1073/pnas.2121333119⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2022, 119 (35), ⟨10.1073/pnas.2121333119⟩
SNPs associated with human stroke risk have been identified in the intergenic region between Forkhead family transcription factors FOXF2 and FOXQ1 , but we lack a mechanism for the association. FoxF2 is expressed in vascular mural pericytes and is im
Autor:
Miriam, Zink, Anne, Seewald, Mareike, Rohrbach, Andreas, Brodehl, Daniel, Liedtke, Tatjana, Williams, Sarah J, Childs, Brenda, Gerull
Publikováno v:
International journal of molecular sciences. 23(17)
Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease caused by heterozygous missense mutations within the gene encoding for the nuclear envelope protein transmembrane protein 43 (
Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy
Autor:
Tatjana Williams, Daniel Liedtke, Henry J. Duff, Nicole M. Munsie, Jan M. Friedman, Saman Rezazadeh, William T. Gibson, Brenda Gerull, Raechel A. Ferrier, Steven J.M. Jones, Yaoqing Shen, Amy L. Stiegler, Titus J. Boggon, Andreas Brodehl, Tracey Oh, Sarah J. Childs
Publikováno v:
Transl Res
Arrhythmogenic cardiomyopathy is a genetic heart muscle disorder characterized by fibro-fatty replacement of cardiomyocytes leading to life-threatening ventricular arrhythmias, heart failure and sudden cardiac death. Mutations in genes encoding cardi
Autor:
Thomas R Whitesell, Regan M Kennedy, Alyson D Carter, Evvi-Lynn Rollins, Sonja Georgijevic, Massimo M Santoro, Sarah J Childs
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90590 (2014)
Mural cells of the vascular system include vascular smooth muscle cells (SMCs) and pericytes whose role is to stabilize and/or provide contractility to blood vessels. One of the earliest markers of mural cell development in vertebrates is α smooth m
Externí odkaz:
https://doaj.org/article/2c96c038c6424675aa829c7cc48f0b75
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9369 (2010)
The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues t
Externí odkaz:
https://doaj.org/article/ad30da9354e64111adcdc4f6e0a65ccc