The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2

Autor: Shamayita Roy, Hemanta Adhikary, Sarah Isler, Damien D'Amours

Publikováno v: eLife, Vol 13 (2024)

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex joined to a displaced strand of genomic DNA. While the effects of R-loops on health and disease are well established, there is still an incomplete understanding of t

Externí odkaz: https://doaj.org/article/56c4852881cf47fb912d82702db51087

Nitrogen gas produces less behavioural and neurophysiological excitation than carbon dioxide in mice undergoing euthanasia

Autor: Regula Bettschart-Wolfensberger, Thomas C. Gent, Martin Wehrle, Carlotta Detotto, Alexei L. Vyssotski, Sarah Isler

Publikováno v: PLoS ONE, 14 (1)
Detotto, Carlotta; Isler, Sarah; Wehrle, Martin; Vyssotski, Alexei L; Bettschart-Wolfensberger, Regula; Gent, Thomas C (2019). Nitrogen gas produces less behavioural and neurophysiological excitation than carbon dioxide in mice undergoing euthanasia. PLoS ONE, 14(1), e0210818. Public Library of Science 10.1371/journal.pone.0210818
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0210818 (2019)

Carbon dioxide (CO2) is one of the most commonly used gas euthanasia agents in mice, despite reports of aversion and nociception. Inert gases such as nitrogen (N2) may be a viable alternative to carbon dioxide. Here we compared behavioural and electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1feef26b5e0e878a87c2be59cc0d9e39
https://hdl.handle.net/20.500.11850/323994