Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sarah Huntwork-Rodriguez"'
Autor:
Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1408-1420 (2023)
Abstract Increased leucine‐rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2 kinase inhibitors are in clinical development as potential novel disease‐modifying therapeutics.
Externí odkaz:
https://doaj.org/article/1457c080406e4c51abbd0acec3fd46d1
Autor:
Xiang Wang, Elvira Negrou, Michael T. Maloney, Vitaliy V. Bondar, Shan V. Andrews, Manuel Montalban, Ceyda Llapashtica, Romeo Maciuca, Hoang Nguyen, Hilda Solanoy, Annie Arguello, Laralynne Przybyla, Nathan J. Moerke, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 k
Externí odkaz:
https://doaj.org/article/1aca3cf646994a96a51018658104a0b3
Autor:
Hardy J. Rideout, Marie-Christine Chartier-Harlin, Matthew J. Fell, Warren D. Hirst, Sarah Huntwork-Rodriguez, Cheryl E. G. Leyns, Omar S. Mabrouk, Jean-Marc Taymans
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative marke
Externí odkaz:
https://doaj.org/article/9b99a1e11ad44ba693fc6e89a5f08950
Autor:
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins
Publikováno v:
eLife, Vol 6 (2017)
The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here
Externí odkaz:
https://doaj.org/article/aede84a0c7d6439186581631dae32ce9
Autor:
Danna Jennings, Sarah Huntwork‐Rodriguez, Maurits F.J.M. Vissers, Vinay M. Daryani, Dolores Diaz, Marisa S. Goo, John J. Chen, Romeo Maciuca, Kyle Fraser, Omar S. Mabrouk, Jeroen van de Wetering de Rooij, Jules A.A.C. Heuberger, Geert Jan Groeneveld, Marie T. Borin, Andrés Cruz‐Herranz, Danielle Graham, Kimberly Scearce‐Levie, Javier De Vicente, Anastasia G. Henry, Peter Chin, Carole Ho, Matthew D. Troyer
Publikováno v:
Movement Disorders. 38:386-398
Autor:
Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez
Publikováno v:
Clinical and Translational Science.
Autor:
Sarah Huntwork-Rodriguez, Jung Suh, Grace Crotty, Romeo Maciuca, Eric Macklin, Sonnet Davis, Jamal Alkabsh, Rachit Bakshi, Xiqun Chen, Samantha Molsberry, Alberto Ascherio, Michael Schwarzschild
Publikováno v:
Sunday, April 23.
Autor:
Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Richard M. Caprioli, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A. Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry
Lysosomal dysfunction is a hallmark of Parkinson’s disease (PD), and variants in several PD-associated genes, includingLRRK2, perturb lysosomal homeostasis. Based on this, LRRK2 kinase inhibition is being explored as a therapeutic approach for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc13473cd36348881c86cb13ff023e4d
https://doi.org/10.1101/2022.12.19.521070
https://doi.org/10.1101/2022.12.19.521070
Autor:
Danna Jennings, Sarah Huntwork-Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, René Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo D. Maciuca, Laura Harris, Angela Kay, Peter LeWitt, T. Alex King, Drew Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang Nguyen, Kimberly Scearce-Levie, Carole Ho, Matthew D. Troyer
Publikováno v:
Science Translational Medicine. 14
Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common genetic risk factors for Parkinson’s disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal function and may contribute to the pathogenesis of PD. Thus, i
Autor:
Manuel Montalban, Xiqun Chen, Jamal I. Alkabsh, Sarah Huntwork-Rodriguez, Michael A. Schwarzschild, Giuseppe Astarita, Junhua Wang, Eric A. Macklin, Rachit Bakshi, Alberto Ascherio, Romeo Maciuca, Sonnet S. Davis, Grace F. Crotty
Publikováno v:
Neurology. 95:e3428-e3437
ObjectiveTo identify markers of resistance to developing Parkinson disease (PD) among LRRK2 mutation carriers (LRRK2+), we carried out metabolomic profiling in individuals with PD and unaffected controls (UC), with and without the LRRK2 mutation.Meth