Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents

Autor: Sarah Huff, Indrasena Reddy Kummetha, Lingzhi Zhang, Lingling Wang, William Bray, Jiekai Yin, Vanessa Kelley, Yinsheng Wang, Tariq M. Rana

Publikováno v: Journal of Medicinal Chemistry. 65:10920-10937

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b65ae28ead01f4dfa90f4a467f8f52c
https://doi.org/10.1021/acs.jmedchem.1c02075

Data from Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy

Autor: Tariq M. Rana, Na Li, Lingling Wang, Indrasena Reddy Kummetha, Sarah Huff, Rachel Tang, Zhouting Zhu

Although immune checkpoint inhibitors targeting T-cell immunoregulatory proteins have revolutionized cancer treatment, they are effective only in a limited number of patients, and new strategies are needed to enhance tumor responses to immunotherapie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd182e0332b515481febdc3177d6137
https://doi.org/10.1158/2767-9764.c.6551172.v1

Cultural adaptation and societal context: The role of historical heterogeneity in cultural adaptation of newcomers

Autor: Sarah Huff, Mary Yoko Brannen, Kathrin J. Hanek, Fiona Lee

Publikováno v: International Journal of Intercultural Relations. 85:141-155

In today’s global world, it has become increasingly important for individuals moving to a different country for work, study, or permanent relocation to successfully adapt to this new culture. Responding to recent calls in the literature for more ec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56c5250bafae8df7099ede6ee877f059
https://doi.org/10.1016/j.ijintrel.2021.09.008

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Autor: Kriti Agrawal, Yuqi Kang, Yinsheng Wang, Sandip Pravin Patel, Hui Hui, Lingling Wang, Gwendolyn Gonzalez, Tariq M. Rana, Rachel Tang, Na Li, Sarah Huff

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 33

Significance N6-methylation of adenosine (m6A) RNA modification plays important roles in development and tumorigenesis. The functions and mechanisms of m6A demethylases during cancer immunotherapy is still unclear. Here we employed melanoma and colon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c6ca7413462e24c020eeb445693e63
https://doi.org/10.1073/pnas.1918986117

The dopamine D4 receptor gene (DRD4) modulates cultural variation in emotional experience

Autor: Anthony P. King, Israel Liberzon, Shinobu Kitayama, Sarah Huff, Carolyn Yoon, Steven H. Tompson

Publikováno v: Culture and Brain. 6:118-129

Prior work suggests that people who carry a 7- or 2-repeat allele of the dopamine D4 receptor gene (DRD4) are more sensitive to environmental influences than those who do not carry this allele. Since culture is an important aspect of the environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a3c90f906a5b894a82598886d4c2197
https://doi.org/10.1007/s40167-018-0063-5