Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems

Autor: Jessica E. Martyn, Giulia Pilla, Sarah Hollingshead, Kristoffer S. Winther, Susan Lea, Gareth McVicker, Christoph M. Tang

Publikováno v: Martyn, J E, Pilla, G, Hollingshead, S, Winther, K S, Lea, S, McVicker, G & Tang, C M 2022, ' Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems ', Journal of Bacteriology, vol. 204, no. 3, e00519-21 . https://doi.org/10.1128/jb.00519-21

Shigella sonnei is a major cause of bacillary dysentery and an increasing concern due to the spread of multidrug resistance. S. sonnei harbors pINV, an;210 kb plasmid that encodes a type III secretion system (T3SS), which is essential for virulence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca31c727fd7bcbff7408775ecdbd77f8
https://pubmed.ncbi.nlm.nih.gov/34978459

The role of toxin:antitoxin systems and insertion sequences in the loss of virulence in Shigella sonnei

Autor: Gareth McVicker, Susan M. Lea, Christoph M. Tang, Sarah Hollingshead, Mariya Lobanovska, Jessica E. Martyn, Kristoffer Skovbo Winther, Giulia Pilla

SUMMARYThe Shigella plasmid, pINV, contains a 30 kb pathogenicity island (PAI) encoding a Type III secretion system (T3SS) which is essential for virulence. During growth in the laboratory, avirulent colonies of Shigella (which do not express a T3SS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::480fc4df3e7bd0e991d315941134e169
https://doi.org/10.1101/2020.08.10.243006

Conserved chloroplast open-reading frame ycf54 is required for activity of the magnesium protoporphyrin monomethylester oxidative cyclase in synechocystis PCC 6803

Autor: Roman Sobotka, Daniel P. Canniffe, Philip J. Jackson, Paul A. Davison, Jana Kopečná, Sarah Hollingshead, Mark J. Dickman, C. Neil Hunter

The cyclase step in chlorophyll (Chl) biosynthesis has not been characterized biochemically, although there are some plausible candidates for cyclase subunits. Two of these, Sll1214 and Sll1874 from the cyanobacterium Synechocystis 6803, were FLAG-ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed076c0dd751290e38084f0be83c5b4
https://doi.org/10.1074/jbc.m112.352526

Structural Design of Chimeric Antigens for Multivalent Protein Vaccines

Autor: Steven Johnson, Ilse Jongerius, Christoph M. Tang, Sarah Hollingshead, Rachel M. Exley, Susan M. Lea

The development of prophylactic vaccines against pathogenic bacteria is a major objective of the World Health Organisation. However, vaccine development is often hindered by antigenic diversity and the difficulties encountered manufacturing immunogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd74f8060fd3b4ae96a1ec2f5557e1f0
https://doi.org/10.1101/187336

Identification of an 8-vinyl reductase involved in bacteriochlorophyll biosynthesis in Rhodobacter sphaeroides and evidence for the existence of a third distinct class of the enzyme

Autor: Sarah Hollingshead, C. Neil Hunter, Daniel P. Canniffe, Mark J. Dickman, Philip J. Jackson

Publikováno v: BIOCHEMICAL JOURNAL

The purple phototrophic bacterium Rhodobacter sphaeroides utilises bacteriochlorophyll a for light harvesting and photochemistry. The synthesis of this photopigment includes the reduction of a vinyl group at the C8 position to an ethyl group, catalys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385027498ff7ed097c1ad2bee3dfe670
https://pubmed.ncbi.nlm.nih.gov/23252506