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Abstract 2796: Tumor pharmacokinetics, pharmacodynamics and efficacy analysis of WEE1 inhibitor, zn-c3 in patient-derived xenograft models of glioblastoma

Autor: Shwetal Mehta, An-Chi Tien, Sonam Patel, Tigran Margaryan, Anilkumar Thaghalli Shivanna, Leonel Elena, Jennifer Molloy, William Knight, Ruiheng Hon, Mackenna Elliott, Mariya Stavnichuk, Zorana Opachich, Yu-Wei Chang, Chelsea Montgomery, Sarah Himes, Barbara Hopkins, Artak Tovmasyan, Nader Sanai

Publikováno v: Cancer Research. 83:2796-2796

WEE1 kinase regulates G2/M checkpoint transition via phosphorylation of CDK1 and prevents entry into mitosis. WEE1 inhibition increases genomic instability due to G2/M checkpoint inactivation and can result in mitotic catastrophe as monotherapy or wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92e3c6e9c10025205e5679597a50fe4d
https://doi.org/10.1158/1538-7445.am2023-2796

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Abstract 349: Pharmacokinetics- and pharmacodynamics-based evaluation of quisinostat as a radiosensitizer in preclinical models of human glioblastoma

Autor: Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James McNamara, William Knight, Sarah Himes, Connor White, Alexis Giff, Jesus Peralta, Nader Sanai, Artak Tovmasyan, Shwetal Mehta

Publikováno v: Cancer Research. 82:349-349

Glioblastoma (GBM), the most common and aggressive primary brain tumor affecting adults, is characterized by an aberrant yet druggable epigenetic landscape. Class I histone deacetylases (HDACs) mediate chromatin compaction and are frequently overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ec62b5b3a2cf9a38ffa8b7cbbdd9d73
https://doi.org/10.1158/1538-7445.am2022-349

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EXTH-24. TUMOR PHARMACOKINETICS, PHARMACODYNAMICS AND RADIATION SENSITIZATION IN PATIENT-DERIVED XENOGRAFT MODELS OF GLIOBLASTOMA TREATED WITH THE SECOND-GENERATION HDAC INHIBITOR, QUISINOSTAT

Autor: James McNamara, Sarah Himes, Costanza Lo Cascio, Nader Sanai, Artak Tovmasyan, Ernesto Luna Melendez, Tigran Margaryan, Shwetal Mehta, William Knight

Publikováno v: Neuro-Oncology. 23:vi168-vi168

BACKGROUND Class I Histone deacetylases (HDACs) are highly expressed in glioblastoma (GBM) and are considered promising therapeutic targets for cancer treatment. Quisinostat is a class I HDAC inhibitor with high specificity for HDAC1 and 2. In this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72fc64bb9f6baa22c48c7c5424d30af8
https://doi.org/10.1093/neuonc/noab196.663

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EXTH-09. TUMOR PHARMACOKINETICS, PHARMACODYNAMICS AND RADIATION SENSITIZATION IN PATIENT-DERIVED XENOGRAFT MODELS OF GLIOBLASTOMA TREATED WITH THE AURORA KINASE A INHIBITOR LY3295668

Autor: An-Chi Tien, Miao Liu, Chelsea Pennington-Krygier, Nader Sanai, Mackenna Elliott, Yu-Wei Chang, Shwetal Mehta, Michael Holter, Tigran Margaryan, Connor White, Jennifer Molloy, William Knight, Barbara Hopkins, Artak Tovmasyan, Ernesto Luna Melendez, Sarah Himes

Publikováno v: Neuro-Oncology. 23:vi165-vi165

Cell-cycle deregulation is at the crux of all malignancies, including glioblastoma (GBM). Aurora Kinase A (AURKA) plays a central role in G2/M transition and faithful chromosome segregation. In this study, we evaluated the pharmacokinetics, pharmacod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f638d7d8aff44b65435397a40cccf60b
https://doi.org/10.1093/neuonc/noab196.648

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