Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sarah Haycock-Lewandowski"'
Publikováno v:
Organic Process Research & Development. 12:1104-1113
A six-step synthetic route to the CCR-5 receptor antagonist, Maraviroc (UK-427,857) (1) has been developed and demonstrated at scale in a pilot plant. The route has supported four Pilot-Plant campa...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c72a50660bb4b6cae4c5db7c011e72e
https://doi.org/10.1021/op800062d
https://doi.org/10.1021/op800062d
Publikováno v:
Organic Process Research & Development. 12:1094-1103
A bulk enabling synthesis of the CCR-5 receptor antagonist, Maraviroc (UK-427,857) (1), is presented. Synthesis of the three key fragments, β-amino ester 3, 4,4-difluorohexanecarboxylic acid (2), a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d4b8fc185ae57e7e8587358ea87472
https://doi.org/10.1021/op8000614
https://doi.org/10.1021/op8000614
Autor:
Simon Gayton, Andrew N. Warren, Blanda Luzia Christa Stammen, Matthew D. Selby, Jens Ahman, Sarah Haycock-Lewandowski, David Price
Publikováno v:
Tetrahedron Letters. 46:5005-5007
The initial synthesis of UK-427,857 (Maraviroc) is described including the preparation of 4,4-difluorocyclohexanoic acid and amide coupling utilizing a polymer supported reagent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b432b44ca8af7eae37bcab0631e83e
https://doi.org/10.1016/j.tetlet.2005.05.082
https://doi.org/10.1016/j.tetlet.2005.05.082
Publikováno v:
ChemInform. 36
A robust synthesis of 1,2,4-triazoles is disclosed with a particular focus on developing methodology capable of delivering gram quantities and minimising hazardous waste.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f2c99e6c6135e34ead2069254b222
https://doi.org/10.1002/chin.200542145
https://doi.org/10.1002/chin.200542145