Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Hawtree"'
Autor:
Sarah Hawtree, Sachin Khetan, Douglas J. Veale, Munitta Muthana, Barbara Ciani, Gbadebo E Adeleke, Fiona Wright, Anthony G. Wilson, Eimear Linehan, Hannah J Roberts, Ursula Fearon, Adam Wilshaw, Mohammed Akil
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(37)
The variant rs26232, in the first intron of the chromosome 5 open reading frame 30 (C5orf30) locus, has recently been associated with both risk of developing rheumatoid arthritis (RA) and severity of tissue damage. The biological activities of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f06a18f6e7bf3e8c0ca5ded2d47607d
https://pubmed.ncbi.nlm.nih.gov/26316022
https://pubmed.ncbi.nlm.nih.gov/26316022
Publikováno v:
Human molecular genetics. 24(19)
Emerging evidence implicates epigenetic mechanisms in the pathogenesis of rheumatoid arthritis (RA). In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f29c1bb08cbaa837525ff42e5865b6
https://pubmed.ncbi.nlm.nih.gov/26152200
https://pubmed.ncbi.nlm.nih.gov/26152200
Publikováno v:
Biochemical Society transactions. 41(3)
RA (rheumatoid arthritis) is an inflammatory disease of synovial joints affecting approximately 1% of the population. One of the main cell types involved in damage to RA joint tissue is the FLSs (fibroblast-like synoviocytes). These have a semi-trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff590bbec4520ce63fdb054fabc58b13
https://pubmed.ncbi.nlm.nih.gov/23697938
https://pubmed.ncbi.nlm.nih.gov/23697938
Autor:
W. J. Hardy, Ursula Fearon, Mauro Perretti, DJ Veale, Munitta Muthana, Anthony G. Wilson, Fiona Wright, Sarah Hawtree
Publikováno v:
Annals of the Rheumatic Diseases. 73:174.2-174
Background In rheumatoid arthritis (RA), the influx of inflammatory cells as well as the aggressive proliferation of fibroblast-like synovial cells (FLS) outstrips the oxygen supply from blood vessels leading to joint hypoxia. Macrophages accumulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46355b91d2aa417ba756952add755952
https://doi.org/10.1136/annrheumdis-2014-eular.4257
https://doi.org/10.1136/annrheumdis-2014-eular.4257
Autor:
Anthony G. Wilson, Sachin Khetan, Sarah Hawtree, Fiona Wright, Munitta Muthana, Barbara Ciani, H. Davies
Publikováno v:
Annals of the Rheumatic Diseases. 73:361.3-361
Background A recent genome wide association study identified the variant rs26232 in the first intron of the uncharacterized gene, C5orf30, as a rheumatoid arthritis (RA) susceptibility variant1. In addition, it has been associated with severity of ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc203a8c701bd6a4620cf8cc8bdb7e5c
https://doi.org/10.1136/annrheumdis-2014-eular.4284
https://doi.org/10.1136/annrheumdis-2014-eular.4284
Publikováno v:
Annals of the Rheumatic Diseases. 73:517.2-517
Background Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS). These FLS are known to develop a stable, auto-aggressiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a13bab1a880b630fd8e8a887a173f4c
https://doi.org/10.1136/annrheumdis-2014-eular.4240
https://doi.org/10.1136/annrheumdis-2014-eular.4240
Autor:
Sachin Khetan, Anthony G. Wilson, Sarah Hawtree, Holly Davies, Adeleke Gbadebo, Fiona Wright, Munitta Muthana, Mohammed Akil, Barbara Ciani
Publikováno v:
Rheumatology. 53:i147-i147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9465969075697cb0f7867c4f06862cb4
https://doi.org/10.1093/rheumatology/keu117.002
https://doi.org/10.1093/rheumatology/keu117.002
Publikováno v:
Rheumatology. 53:i85-i85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6eb5df8605d8d390bde045549fa36a5
https://doi.org/10.1093/rheumatology/keu100.004
https://doi.org/10.1093/rheumatology/keu100.004
Publikováno v:
Annals of the Rheumatic Diseases. 72:A165.4-A166
Background Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of the synovial lining layer, which includes fibroblast-like synoviocytes (FLS). These FLS dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7098db19039cd674fcc9f93eee742238
https://doi.org/10.1136/annrheumdis-2013-eular.532
https://doi.org/10.1136/annrheumdis-2013-eular.532
Autor:
Sachin Khetan, Barbara Ciani, Anthony G. Wilson, H. Davies, Munitta Muthana, Sarah Hawtree, Gbadebo E Adeleke, Fiona Morrow
Publikováno v:
Annals of the Rheumatic Diseases. 72:A190.2-A190
Background A recent genome wide association study identified the variant rs26232 in the first exon of an uncharacterized gene C5orf30 as a rheumatoid arthritis susceptibility variant 1 . In addition, it has been associated with severity of radiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d00bc7bc6fab5a6db021a147cc0563
https://doi.org/10.1136/annrheumdis-2013-eular.608
https://doi.org/10.1136/annrheumdis-2013-eular.608