Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sarah H. Vermij"'
Autor:
Alejandra Leo-Macias, Mingliang Zhang, Marta Pérez-Hernández, Paul W. Burridge, Feng-Xia Liang, Mario Delmar, Sarah Keegan, Joon Chul Kim, David Fenyö, Esperanza Agullo-Pascual, Eli Rothenberg, Mariam Jouni, Sarah H. Vermij
Publikováno v:
Circulation Research. 128:419-432
Rationale: The cardiac sodium channel Na V 1.5 has a fundamental role in excitability and conduction. Previous studies have shown that sodium channels cluster together in specific cellular subdomains. Their association with intracellular organelles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::835a48d70a860f85e6d5a27261415864
https://doi.org/10.1161/circresaha.120.318239
https://doi.org/10.1161/circresaha.120.318239
Autor:
Geoffrey S. Pitt, Valentin Sottas, Zizun Wang, Daniela Ross-Kaschitza, Sarah H. Vermij, Jean-Sébastien Rougier, Hugues Abriel, Elena Zaklyazminskaya, Anna Shestak, Andy Hudmon
The cardiac voltage-gated sodium channel Nav1.5 conducts the rapid inward sodium current crucial for cardiomyocyte excitability. Loss-of-function mutations in its gene SCN5A are linked to cardiac arrhythmias such as Brugada Syndrome (BrS). Several Br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146794d8059b25a503a6f70c98cf4080
https://doi.org/10.1101/2020.06.02.129288
https://doi.org/10.1101/2020.06.02.129288
Autor:
Jean-Sébastien Rougier, Esperanza Agulló-Pascual, Hugues Abriel, Eli Rothenberg, Sarah H. Vermij, Mario Delmar
Publikováno v:
Circulation. Arrhythmia and Electrophysiology
Vermij, Sarah H.; Rougier, Jean-Sébastien; Agulló-Pascual, Esperanza; Rothenberg, Eli; Delmar, Mario; Abriel, Hugues (2020). Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains. Circulation. Arrhythmia and electrophysiology, 13(7), pp. 628-639. Lippincott Williams & Wilkins 10.1161/CIRCEP.119.008241
Vermij, Sarah H.; Rougier, Jean-Sébastien; Agulló-Pascual, Esperanza; Rothenberg, Eli; Delmar, Mario; Abriel, Hugues (2020). Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains. Circulation. Arrhythmia and electrophysiology, 13(7), pp. 628-639. Lippincott Williams & Wilkins 10.1161/CIRCEP.119.008241
Supplemental Digital Content is available in the text.
Background: Mutations in the gene encoding the cardiac voltage-gated sodium channel Nav1.5 cause various cardiac arrhythmias. This variety may arise from different determinants of Nav1.5 exp
Background: Mutations in the gene encoding the cardiac voltage-gated sodium channel Nav1.5 cause various cardiac arrhythmias. This variety may arise from different determinants of Nav1.5 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f183aef6656ea8b824bc7c0acd22a71
Autor:
Mingliang Zhang, Chantal J. M. van Opbergen, Maartje Noorman, Harold V.M. van Rijen, Mario Delmar, Sarah H. Vermij, Anna Pfenniger, Jacques M.T. de Bakker, Marc A. Vos, Zhen Li, Roel van der Nagel, Aaron Glass, Jaël S Copier, Steven M. Taffet, Toon A.B. van Veen, Peter J. Mohler
Publikováno v:
International journal of molecular sciences, 20(17). Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4076 (2019)
International Journal of Molecular Sciences
van Opbergen, Chantal J M; Noorman, Maartje; Pfenniger, Anna; Copier, Jaël S; Vermij, Sarah H.; Li, Zhen; van der Nagel, Roel; Zhang, Mingliang; de Bakker, Jacques M T; Glass, Aaron M; Mohler, Peter J; Taffet, Steven M; Vos, Marc A; van Rijen, Harold V M; Delmar, Mario; van Veen, Toon A B (2019). Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. International journal of molecular sciences, 20(17) Molecular Diversity Preservation International MDPI 10.3390/ijms20174076
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4076 (2019)
International Journal of Molecular Sciences
van Opbergen, Chantal J M; Noorman, Maartje; Pfenniger, Anna; Copier, Jaël S; Vermij, Sarah H.; Li, Zhen; van der Nagel, Roel; Zhang, Mingliang; de Bakker, Jacques M T; Glass, Aaron M; Mohler, Peter J; Taffet, Steven M; Vos, Marc A; van Rijen, Harold V M; Delmar, Mario; van Veen, Toon A B (2019). Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. International journal of molecular sciences, 20(17) Molecular Diversity Preservation International MDPI 10.3390/ijms20174076
Volume 20
Issue 17
Human variants in plakophilin-2 (PKP2) associate with most cases of familial arrhythmogenic cardiomyopathy (ACM). Recent studies show that PKP2 not only maintains intercellular coupling, but also regulates transcription of genes involved in Ca2+ cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612a305374d1d1c344284cc5084b43b4
https://pure.amc.nl/en/publications/plakophilin2-haploinsufficiency-causes-calcium-handling-deficits-and-modulates-the-cardiac-response-towards-stress(2519daf6-96ab-4286-8e3a-ce0c4826d452).html
https://pure.amc.nl/en/publications/plakophilin2-haploinsufficiency-causes-calcium-handling-deficits-and-modulates-the-cardiac-response-towards-stress(2519daf6-96ab-4286-8e3a-ce0c4826d452).html
Publikováno v:
Vermij, Sarah Helena; Abriel, Hugues; Kucera, Jan (2019). Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules. Frontiers in physiology, 10(1487) Frontiers Research Foundation 10.3389/fphys.2019.01487
Frontiers in Physiology
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Frontiers in Physiology, Vol 10 (2019)
T-tubules are invaginations of the lateral membrane of striated muscle cells that provide a large surface for ion channels and signaling proteins, thereby supporting excitation–contraction coupling. T-tubules are often remodeled in heart failure. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd84d8ee102291043893b3baf8629702
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118502
This work discusses active and passive electrical properties of transverse (T-)tubules in ventricular cardiomyocytes to understand the physiological roles of T-tubules. T-tubules are invaginations of the lateral membrane that provide a large surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef51288de625d6ed7b4fc8426522afd
https://doi.org/10.1016/j.bbamcr.2019.06.016
https://doi.org/10.1016/j.bbamcr.2019.06.016
Autor:
Irene Keller, Hugues Abriel, Morgan Yoann Edwin Chevalier, Sarah H. Vermij, Ludovic Gillet, Kurt Wyler
Publikováno v:
Scientific Data. 5
Correction to: Scientific Data https://doi.org/10.1038/sdata.2018.170, published online 21 August 2018. In the CASK and SAP97 knockout mice sub-section of the Methods in this Data Descriptor it is incorrectly stated that CASK KO mice were generated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4021d43efaa10584db4b38ebf2158d9
Autor:
Irene Keller, Kurt Wyler, Ludovic Gillet, Hugues Abriel, Morgan Yoann Edwin Chevalier, Sarah H. Vermij
Publikováno v:
Scientific Data, vol. 5, pp. 180170
Chevalier, Morgan; Vermij, Sarah H.; Wyler, Kurt; Gillet, Ludovic; Keller, Irene; Abriel, Hugues (2018). Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific data, 5(180170), p. 180170. Nature Publishing Group 10.1038/sdata.2018.170
Scientific Data
Chevalier, Morgan; Vermij, Sarah H.; Wyler, Kurt; Gillet, Ludovic; Keller, Irene; Abriel, Hugues (2018). Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific data, 5(180170), p. 180170. Nature Publishing Group 10.1038/sdata.2018.170
Scientific Data
Mice are used universally as model organisms for studying heart physiology, and a plethora of genetically modified mouse models exist to study cardiac disease. Transcriptomic data for whole-heart tissue are available, but not yet for isolated ventric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef9bb0fc9020fc2d19bf9ea5890f7a
https://serval.unil.ch/notice/serval:BIB_0C3727C1173F
https://serval.unil.ch/notice/serval:BIB_0C3727C1173F
Publikováno v:
Cardiovascular Research, 113(3), 259. Oxford University Press
Vermij, Sarah Helena; Abriel, Hugues; van Veen, Toon A B (2017). Refining the molecular organization of the cardiac intercalated disc. Cardiovascular research, 113(3), pp. 259-275. Oxford University Press 10.1093/cvr/cvw259
Vermij, Sarah Helena; Abriel, Hugues; van Veen, Toon A B (2017). Refining the molecular organization of the cardiac intercalated disc. Cardiovascular research, 113(3), pp. 259-275. Oxford University Press 10.1093/cvr/cvw259
This review presents an extensively integrated model of the cardiac intercalated disc (ID), a highly orchestrated structure that connects adjacent cardiomyocytes. Classically, three main structures are distinguished: gap junctions (GJs) metabolically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5de796cdfa354296a3636ab664e0755
https://hdl.handle.net/1874/359309
https://hdl.handle.net/1874/359309