Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sarah H, Shafik"'
Autor:
Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites
Externí odkaz:
https://doaj.org/article/2487d4ef217541f185f3c2fd767c2794
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Lily Chen, Diep R Ganguly, Sarah H Shafik, Florence Danila, Christopher P L Grof, Robert E Sharwood, Robert T Furbank
Publikováno v:
Journal of Experimental Botany. 74:2968-2986
In the developing seeds of all higher plants, filial cells are symplastically isolated from the maternal tissue supplying photosynthate to the reproductive structure. Photoassimilates must be transported apoplastically, crossing several membrane barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c444b2e5f595dd89c355a22890b6f7a
https://doi.org/10.1093/jxb/erad076
https://doi.org/10.1093/jxb/erad076
Autor:
Zachary R Sailer, Sarah H Shafik, Robert L Summers, Alex Joule, Alice Patterson-Robert, Rowena E Martin, Michael J Harms
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Externí odkaz:
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
Autor:
Maria Ermakova, Robert E. Sharwood, Robert T. Furbank, Barry J. Pogson, Diep Ganguly, Christopher P. L. Grof, Lily Chen, Sarah H. Shafik
Publikováno v:
The Plant Journal. 109:615-632
Photosynthetic efficiency and sink demand are tightly correlated with rates of phloem loading where maintaining low cytosolic sugar concentrations is paramount to prevent downregulation of photosynthesis. Sugars Will Eventually be Exported Transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8ad7ea1b00a6c4c8b942656d896b39
https://doi.org/10.1111/tpj.15581
https://doi.org/10.1111/tpj.15581
Autor:
Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide S M Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006180 (2017)
In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification
Externí odkaz:
https://doaj.org/article/af29320f19f24b8b9d2b5dfd5482a5da
Autor:
Sashika N Richards, Megan N Nash, Eileen S Baker, Michael W Webster, Adele M Lehane, Sarah H Shafik, Rowena E Martin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005725 (2016)
Mutations in the Plasmodium falciparum 'chloroquine resistance transporter' (PfCRT) confer resistance to chloroquine (CQ) and related antimalarials by enabling the protein to transport these drugs away from their targets within the parasite's digesti
Externí odkaz:
https://doaj.org/article/c5c24d1b429c4890955f2192f5a69ecb
Autor:
Lily, Chen, Diep R, Ganguly, Sarah H, Shafik, Maria, Ermakova, Barry J, Pogson, Christopher P L, Grof, Robert E, Sharwood, Robert T, Furbank
Publikováno v:
The Plant journal : for cell and molecular biologyREFERENCES. 109(3)
Photosynthetic efficiency and sink demand are tightly correlated with rates of phloem loading, where maintaining low cytosolic sugar concentrations is paramount to prevent the downregulation of photosynthesis. Sugars Will Eventually be Exported Trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3f333fd33363f8dbb681fd852192451
https://pubmed.ncbi.nlm.nih.gov/34780111
https://pubmed.ncbi.nlm.nih.gov/34780111
Autor:
Robert L. Summers, Annette Habluetzel, Stefania Lamponi, Sandra Gemma, Rowena E. Martin, Sarah H. Shafik, Stefano Federico, Reto Caldelari, Donatella Taramelli, Luca Pozzetti, Giuseppe Campiani, Sarah D'Alessandro, Stefania Butini, Simone K. Babij, Nicola Relitti, Sofia Tapanelli
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite’s digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8956bb26e1162a62798dcc944865de
http://hdl.handle.net/11365/1141531
http://hdl.handle.net/11365/1141531
Autor:
Alex Joule, Alice Patterson-Robert, Zachary R. Sailer, Michael J. Harms, Rowena E. Martin, Sarah H. Shafik, Robert L. Summers
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
PLoS Computational Biology
PLoS Computational Biology
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8101258a3c1a18ebec96e6ffceca91
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8