Adjuvant treatment for high risk melanoma. Where are we now?

Autor: Anand Sharma, Tahir Abbas, Sarah Gwynne

Publikováno v: Oncology Reviews, Vol 2, Iss 1, Pp 53-60 (2011)

The survival rate for stage 3 and 4 melanoma is very poor. In the absence of effective treatments for metastatic disease focus has shifted to the adjuvant setting. While we are now able to identify those who are at high risk of recurrence the role of

Externí odkaz: https://doaj.org/article/c8220817b5ee4a7f8b8f7d5c35387e67

Supplementary Data from Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer

Autor: Andrew Godkin, Awen Gallimore, Robert Hills, Richard Harrop, Daniel Blount, Sarah Gwynne, Robert Jones, Alison Brewster, Richard Adams, Hayley Bridgeman, Kathryn Smart, Amanda Thomson, David Roberts, Anja Bloom, Tom Pembroke, Martin Scurr

Supplementary Figure 1. CONSORT diagram. Supplementary Figure 2. 5T4 peptide pools and matrix system. Supplementary Figure 3. B-cell number in response to cyclophosphamide. Supplementary Figure 4. Expression of activation markers in T-cell subsets du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccf646f32661490d9797c502cb70e8a
https://doi.org/10.1158/1078-0432.22462886.v1

The Promise of Proton Beam Therapy for Oesophageal Cancer: A Systematic Review of Dosimetric and Clinical Outcomes

Autor: S. Prosser, Hanna Rahbek Mortensen, Sarah Gwynne, M. A Hawkins, Ganesh Radhakrishna, O. Nicholas

Publikováno v: Nicholas, O, Prosser, S, Mortensen, H R, Radhakrishna, G, Hawkins, M A & Gwynne, S H 2021, ' The Promise of Proton Beam Therapy for Oesophageal Cancer : A Systematic Review of Dosimetric and Clinical Outcomes ', Clinical Oncology, vol. 33, no. 8, pp. e339-e358 . https://doi.org/10.1016/j.clon.2021.04.003

Aims Due to its physical advantages over photon radiotherapy, proton beam therapy (PBT) has the potential to improve outcomes from oesophageal cancer. However, for many tumour sites, high-quality evidence supporting PBT use is limited. We carried out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5981fd0ed51af1bc12ce59ca226d2c2
https://doi.org/10.1016/j.clon.2021.04.003

Patient and Public Involvement Refines the Design of ProtOeus: A Proposed Phase II Trial of Proton Beam Therapy in Oesophageal Cancer

Autor: Annie Keane, Tom Crosby, Kate Cleary, Olivier Joseph, Ganesh Radhakrishna, Maria A. Hawkins, Sue Campbell, Sarah Gwynne, O. Nicholas

Publikováno v: The Patient - Patient-Centered Outcomes Research. 14:545-553

Neoadjuvant chemoradiotherapy for oesophageal cancer significantly improves overall survival but is associated with severe post-operative complications. Proton beam therapy may reduce these toxicities by sparing normal tissues compared with standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07735b6801ab69e9956c5671ef221481
https://doi.org/10.1007/s40271-020-00487-8

Volumetric modulated arc radiotherapy with concomitant chemotherapy for the anal squamous carcinoma: A Welsh experience

Autor: Mutahar Ali Tunio, Craig Barrington, Mau-Don Phan, Sarah Gwynne, Mark Davies, Rhiannon Harries

Publikováno v: Clinical Oncology. 34:e18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0f79680400fb7052cce2234c9f9fdb
https://doi.org/10.1016/j.clon.2022.09.036