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pro vyhledávání: '"Sarah Gulla"'
Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate cancer
Autor:
Weiwei Han, Liang Wang, Xiaoping Zhang, Hongmei Yang, Shaoyong Chen, Sarah Gulla, Yanfei Gao, Jihong Liu, Xiaming Liu, Nicholas I. Simon
Publikováno v:
The Prostate. 76:649-661
BACKGROUND Previous reports have documented protein phosphatase 1 (PP1) as an essential androgen receptor (AR) activator. However, more systemic studies are needed to further define PP1 effects on AR, particularly in the settings of prostate cancer c
Autor:
Weiwei Han, Nicholas I. Simon, Xiaming Liu, Shaoyong Chen, Steven P. Balk, Xiaoping Zhang, Sarah Gulla, Yanfei Gao, Jihong Liu, Changmeng Cai, Hongmei Yang
Publikováno v:
Oncotarget
The phosphoprotein phosphatases are emerging as important androgen receptor (AR) regulators in prostate cancer (PCa). We reported previously that the protein phosphatase 1 catalytic subunit (PP1α) can enhance AR activity by dephosphorylating a site
Publikováno v:
Journal of Biological Chemistry. 287:8571-8583
Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is stimulated by the mitotic cyclin-dependent kinase 1 (CDK1). In this report, we extended our previous study and confirmed that Ser-81 phosphorylation increases
Androgen ablation elicits PP1-dependence for AR stabilization and transactivation in prostate cancer
Autor:
Xiaming, Liu, Weiwei, Han, Sarah, Gulla, Nicholas I, Simon, Yanfei, Gao, Jihong, Liu, Liang, Wang, Hongmei, Yang, Xiaoping, Zhang, Shaoyong, Chen
Publikováno v:
The Prostate. 76(7)
Previous reports have documented protein phosphatase 1 (PP1) as an essential androgen receptor (AR) activator. However, more systemic studies are needed to further define PP1 effects on AR, particularly in the settings of prostate cancer cells and un