Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Sarah Grimwood"'
Autor:
Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
Publikováno v:
Journal of Medicinal Chemistry. 60:6649-6663
Recent data demonstrated that activation of the muscarinic M1 receptor by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI) and cardiovascular (CV) cholinergic adverse events (AEs) previously attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
https://doi.org/10.1021/acs.jmedchem.7b00597
https://doi.org/10.1021/acs.jmedchem.7b00597
Autor:
Angela C. Doran, Cheng Chang, Shenping Liu, Butler Todd W, Travis T. Wager, Klaas Schildknegt, Lei Zhang, Michael Marconi, Jianke Li, Scot Richard Mente, Katherine Fisher, Ramalakshmi Yegna Chandrasekaran, Joseph R. Hedde, Sarah Grimwood, Chakrapani Subramanyam, Paul Galatsis
Publikováno v:
ACS Chemical Neuroscience. 8:1995-2004
To enable the clinical development of our CNS casein kinase 1 delta/epsilon (CK1δ/e) inhibitor project, we investigated the possibility of developing a CNS positron emission tomography (PET) radioligand. For this effort, we focused our design and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7a24bb9dc9c4035e136f3bff24189
https://doi.org/10.1021/acschemneuro.7b00155
https://doi.org/10.1021/acschemneuro.7b00155
Autor:
Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
Publikováno v:
Biochemistry. 55:7073-7085
The rationale for using M1 selective muscarinic acetylcholine receptor activators for the treatment of cognitive impairment associated with psychiatric and neurodegenerative disease is well-established in the literature. Here, we investigate measurem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d948042e32f463780f579df4556d74
https://doi.org/10.1021/acs.biochem.6b00688
https://doi.org/10.1021/acs.biochem.6b00688
Autor:
Christopher Ryan Butler, Qingyi Yang, Michael Popiolek, Natasha M. Kablaoui, Lei Zhang, Sarah Grimwood, John T. Lazzaro, Rouba Kozak, Damien Webb, Rebecca E. O’Connor, Erik Alphie Lachapelle
Publikováno v:
ACS Med Chem Lett
[Image: see text] It has been hypothesized that selective muscarinic acetylcholine receptor (mAChR) M4 subtype activation could provide therapeutic benefits to a number of neurological disorders while minimizing unwanted cholinergic side effects obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b7038f52a14a71fc93cf610efea16b
https://pubmed.ncbi.nlm.nih.gov/31223452
https://pubmed.ncbi.nlm.nih.gov/31223452
Autor:
Christoffer Bundgaard, Vladimir Stepanov, Stefan Martinsson, Christer Halldin, Nahid Amini, Lars Farde, Sjoerd J. Finnema, Akihiro Takano, Benny Bang-Andersen, Sarah Grimwood, Kai-Chun Yang, Jacob Nielsen
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 44:308-320
[11C]Lu AE92686 is a positron emission tomography (PET) radioligand that has recently been validated for examining phosphodiesterase 10A (PDE10A) in the human striatum. [11C]Lu AE92686 has high affinity for PDE10A (IC 50 = 0.39 nM) and may also be su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf5272186f34818653999edfd6ec278
https://doi.org/10.1007/s00259-016-3544-9
https://doi.org/10.1007/s00259-016-3544-9
Autor:
Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee
Publikováno v:
Molecular Pharmacology. 90:177-187
Selective activation of the M1 muscarinic acetylcholine receptor (mAChR) via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. Herein, we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4cbb153c3abcd01cb4427f9543370
https://doi.org/10.1124/mol.116.104737
https://doi.org/10.1124/mol.116.104737
Autor:
Edilio Borroni, Christer Halldin, Mohammed Shahid, Jussi Lehto, Mika Scheinin, Lars Farde, Sarah Grimwood, Sjoerd J. Finnema, Jukka Sallinen, Benny Bang-Andersen, Erik H. F. Wong
Publikováno v:
Psychopharmacology
Rationale This review attempts to summarize the current status in relation to the use of positron emission tomography (PET) imaging in the assessment of synaptic concentrations of endogenous mediators in the living brain. Objectives Although PET radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc3fde5c1449471a65c1fd5bc89bee8
https://doi.org/10.1007/s00213-015-3938-6
https://doi.org/10.1007/s00213-015-3938-6
Autor:
Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
Publikováno v:
Journal of medicinal chemistry. 60(15)
Recent data demonstrated that activation of the muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29248df43dd90a74489fbab479a9cfba
https://pubmed.ncbi.nlm.nih.gov/28598634
https://pubmed.ncbi.nlm.nih.gov/28598634
Autor:
Patrick Robert Verhoest, Susan E. Drozda, Kenneth R. Zasadny, Emily Miller, Lei Zhang, Kari R. Fonseca, Gabriela Barreiro, Patrick Trapa, Michelle Marie Claffey, Julie Cianfrogna, Marc B. Skaddan, Deborah L. Smith, Margaret M. Zaleska, Joshua R. Dunetz, Christopher L. Shaffer, Jessica Mancuso, Isao Sakurada, Gayatri Balan, Jamison B. Tuttle, Lois K. Chenard, Bruce N. Rogers, Matthew R. Reese, Antonia F. Stepan, Paul Galatsis, Brian P. Boscoe, Daniel P. Walker, Sarah Grimwood, Ann S. Wright, John T. Lazzaro, Karen J. Coffman, Laigao Chen
Publikováno v:
Journal of Medicinal Chemistry. 57:861-877
A novel series of pyrazolopyrazines is herein disclosed as mGluR5 negative allosteric modulators (NAMs). Starting from a high-throughput screen (HTS) hit (1), a systematic structure-activity relationship (SAR) study was conducted with a specific focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87c83f67fb92d09c6e15f29a119306f
https://doi.org/10.1021/jm401622k
https://doi.org/10.1021/jm401622k
Autor:
Michael, Popiolek, David P, Nguyen, Veronica, Reinhart, Jeremy R, Edgerton, John, Harms, Susan M, Lotarski, Stefanus J, Steyn, Jennifer E, Davoren, Sarah, Grimwood
Publikováno v:
Biochemistry. 55(51)
The rationale for using M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::385a83d5d30f6dd8dc8ed05cdb55a4c3
https://pubmed.ncbi.nlm.nih.gov/27958713
https://pubmed.ncbi.nlm.nih.gov/27958713