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Akademický článek

Inflammation—The new treatment target for ischaemic stroke prevention

Autor: Sarah Gorey, John J. McCabe, Peter J. Kelly

Publikováno v: Frontiers in Stroke, Vol 2 (2023)

Recurrent vascular events after stroke are common despite contemporary therapies and there is an unmet clinical need for improved secondary prevention. Inflammation is a probable causal factor in first and recurrent stroke and is a promising therapeu

Externí odkaz: https://doaj.org/article/77a6610cd87c4d34af1a62d07cce1934

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Akademický článek

Effect of a Run‐In Period on Estimated Treatment Effects in Cardiovascular Randomized Clinical Trials: A Meta‐Analytic Review

Autor: Robert P. Murphy, Martin J. O’Donnell, Aoife Nolan, Emer McGrath, Aengus O’Conghaile, John Ferguson, Alberto Alvarez‐Iglesias, Maria Costello, Elaine Loughlin, Catriona Reddin, Sarah Ruttledge, Sarah Gorey, Diarmaid Hughes, Andrew Smyth, Michelle Canavan, Conor Judge

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 20 (2022)

Background A run‐in period may increase adherence to intervention and reduce loss to follow‐up. Whether use of a run‐in period affects the magnitude of treatment effects is unknown. Methods and Results We conducted a meta‐analysis comparing t

Externí odkaz: https://doaj.org/article/171e521142744aaf983938d4b8f09795

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Akademický článek

Imaging Carotid Plaque Inflammation Using Positron Emission Tomography: Emerging Role in Clinical Stroke Care, Research Applications, and Future Directions

Autor: John J. McCabe, Nicholas R. Evans, Sarah Gorey, Shiv Bhakta, James H. F. Rudd, Peter J. Kelly

Publikováno v: Cells, Vol 12, Iss 16, p 2073 (2023)

Atherosclerosis is a chronic systemic inflammatory condition of the vasculature and a leading cause of stroke. Luminal stenosis severity is an important factor in determining vascular risk. Conventional imaging modalities, such as angiography or dupl

Externí odkaz: https://doaj.org/article/020e4b0dfbdb46c9b828d85b59b4b779

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C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke:An Individual Participant Data Meta-Analysis

Autor: John J. McCabe, Cathal Walsh, Sarah Gorey, Katie Harris, Pablo Hervella, Ramon Iglesias-Rey, Christina Jern, Linxin Li, Nobukazu Miyamoto, Joan Montaner, Annie Pedersen, Francisco Purroy, Peter M. Rothwell, Catherine Sudlow, Yuji Ueno, Mikel Vicente-Pascual, William Whiteley, Mark Woodward, Peter J. Kelly

Publikováno v: McCabe, J J, Walsh, C, Gorey, S, Harris, K, Hervella, P, Iglesias-Rey, R, Jern, C, Li, L, Miyamoto, N, Montaner, J, Pedersen, A, Purroy, F, Rothwell, P M, Sudlow, C, Ueno, Y, Vicente-Pascual, M, Whiteley, W, Woodward, M & Kelly, P J 2023, ' C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke : An Individual Participant Data Meta-Analysis ', Stroke . https://doi.org/10.1161/STROKEAHA.122.040529

Background: Anti-inflammatory therapies reduce recurrent vascular events in coronary disease. Existing studies have reported highly conflicting findings for the association of blood inflammatory markers with vascular recurrence after stroke leading t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e2c9fd3ba4017cd45cd7c6a6fcd181
https://www.pure.ed.ac.uk/ws/files/343425111/Final_Mansucript_BISC_for_Publication_clean.docx

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Effect of non‐vitamin‐K oral anticoagulants on stroke severity compared to warfarin: a meta‐analysis of randomized controlled trials

Autor: Conor Judge, Sarah Ruttledge, Michelle Canavan, Elaine Loughlin, Martin O'Donnell, Diarmuid Hughes, Maria Costello, Robert Murphy, Aoife Nolan, Sarah Gorey

Publikováno v: European Journal of Neurology. 27:413-418

Background and purpose In addition to lowering stroke risk, warfarin use is also associated with reduced stroke severity in patients with atrial fibrillation and acute ischaemic stroke. It was sought to determine whether the effect of non-vitamin-K o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5382a2f3e4c3afabc321247ea1b94b0a
https://doi.org/10.1111/ene.14134

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Generalist vs specialist acute medical admissions - What is the impact of moving towards acute medical subspecialty admissions on efficacy of care provision?

Autor: Hannah Smyth, Sarah Gorey, Hannah O'Keeffe, Joanna Beirne, Shaunna Kelly, Cathal Clifford, Hilary Kerr, Martin Mulroy, Tomás Ahern

Publikováno v: European journal of internal medicine. 98

The discussion surrounding generalist versus specialist acute medical admissions continues to stimulate debate and patients with certain conditions benefit from specialist care.To determine whether a specialty medical admission program would reduce i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6d41fc38f31f8946ab61c81c6c4d81
https://pubmed.ncbi.nlm.nih.gov/35172943

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317 Incidence of Cognitive Impairment after Stroke: a Retrospective Cohort of Rehabilitation Patients

Autor: Tim Cassidy, Sarah Gorey

Publikováno v: Age and Ageing. 48:iii17-iii65

Background Pendlebury and Rothwell’s recent paper reports the incidence of cognitive impairment and dementia post stroke as 5% for TIA, 8% for minor stroke and 34% for severe stroke. 1We wanted to explore if these trends were reproducible in an Iri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0becf04cc98786e090ac9f954524514f
https://doi.org/10.1093/ageing/afz103.204

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