Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sarah Golden"'
Autor:
Matthew Paul Constantinou, Jessica Stepanous, Suzet Tanya Lereya, Hannah Wilkinson, Sarah Golden, Jessica Deighton
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background There is a pressing need to offer more accessible, evidence-based psychological interventions to secondary school students who are increasingly reporting difficulties with anxiety and low mood. The aim of this pragmatic randomised
Externí odkaz:
https://doaj.org/article/34b9b6b640cf40eaa47174776c6f9faa
Publikováno v:
Child and Adolescent Mental Health. 28:277-286
Children's mental health is deteriorating while access to child and adolescent mental health services is decreasing. Recent UK policy has focused on schools as a setting for the provision of mental health services, and counselling is the most common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbf8640ca55e9f9233f2b0342a8e95c
https://www.repository.cam.ac.uk/handle/1810/323949
https://www.repository.cam.ac.uk/handle/1810/323949
Publikováno v:
Child and adolescent mental healthReferences.
Exclusion from school is a disciplinary tool with an increasingly recognised relationship to poor mental health among children and young people. We explored the relationship between mental health and school exclusion for a cohort of children and youn
Publikováno v:
Counselling and Psychotherapy Research. 20:571-579
Background: Poor mental health reduces children’s ability to function at school, which in turn may undermine their mental health. The provision of school-based counselling aims to help schools to support their pupil’s mental health. Most work on
Publikováno v:
Counselling Psychology Quarterly. 34:21-36
The use of systematic client feedback tools are known to enhance outcomes in adults psychotherapy clients, but their effects with children have yet to be adequately tested. Hence, we piloted a clus...
Autor:
Royce A. Wilkinson, Wang-Ting Lu, Gabriel C. Lander, Sarah Golden, Andrew Santiago-Frangos, Marscha Hirschi, Alan R. Davidson, Blake Wiedenheft
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Bacteria have evolved sophisticated adaptive immune systems, called CRISPR-Cas, that provide sequence-specific protection against phage infection. In turn, phages have evolved a broad spectrum of anti-CRISPRs that suppress these immune systems. Here
Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-Guided Cascade Complex
Autor:
Angela Patterson, Luke Berry, Brittney L. Forsman, Ravi Kant, Sarah Golden, Joshua Carter, Ryan N. Jackson, Blake Wiedenheft, Paul B. G. van Erp, Brian Bothner
Publikováno v:
ACS Chemical Biology. 13:481-490
Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems for sequence specific elimination of foreign nucleic acids. In Escherichia coli, short CRISPR-derived RNAs (crRNAs) ass
Autor:
Saikat Chowdhury, Blake Wiedenheft, Heini M. Miettinen, Andrew Santiago-Frangos, C. Martin Lawrence, Dominick Faith, Joshua Carter, Gabriel C. Lander, Sarah Golden, MaryClare F. Rollins
Bacteria and archaea have evolved sophisticated adaptive immune systems that rely on CRISPR RNA (crRNA)-guided detection and nuclease-mediated elimination of invading nucleic acids. Here we present the cryo-EM structure of the type I-F CRISPR RNA-gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8588a0f3439359e317bad2612663307
https://doi.org/10.1101/453720
https://doi.org/10.1101/453720
Autor:
C. Martin Lawrence, Saikat Chowdhury, Sarah Golden, MaryClare F. Rollins, Gabriel C. Lander, Andrew Santiago-Frangos, Dominick Faith, Blake Wiedenheft, Joshua Carter, Heini M. Miettinen
Publikováno v:
Molecular cell. 74(1)
Summary Bacteria and archaea have evolved sophisticated adaptive immune systems that rely on CRISPR RNA (crRNA)-guided detection and nuclease-mediated elimination of invading nucleic acids. Here, we present the cryo-electron microscopy (cryo-EM) stru