Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Sarah Gillemot"'
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Akademický článek
An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness
Autor: Erika Trompet, Arturo Temblador, Sarah Gillemot, Dimitrios Topalis, Robert Snoeck, Graciela Andrei
Publikováno v: Viruses, Vol 13, Iss 6, p 985 (2021)
Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a mode
Externí odkaz: https://doaj.org/article/9bc732931f72444e8153ef215e4b289c
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2
A Herpes Simplex virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in an Immunocompromised Patient - Confirmed by Gene Editing
Autor: Hanna Helena Schalkwijk, Aspasia Georgala, Sarah Gillemot, Arturo Temblador, Dimitri Topalis, Sebastian Wittnebel, Graciela Andrei, Robert Snoeck
Publikováno v: The Journal of Infectious Diseases.
Background Herpes simplex virus-1 (HSV-1) can cause severe infections in immunocompromised individuals. In these patients, emergence of drug-resistance mutations causes difficulties in the infection management. Methods Seventeen HSV-1 isolates were o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::048641f61f23354e1b06e1f654b5158e
https://doi.org/10.1093/infdis/jiad184
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3
Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase
Autor: Hanna Helena Schalkwijk, Sarah Gillemot, Marijke Reynders, Dominik Selleslag, Graciela Andrei, Robert Snoeck
Publikováno v: The Journal of antimicrobial chemotherapy. 77(11)
Background Prolonged antiviral therapy in immunocompromised individuals can result in the emergence of (multi)drug-resistant herpes simplex virus 1 (HSV-1) infections, forming a therapeutic challenge. Objectives To evaluate spatial and temporal diffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff83c6fa53660bcc72bedf2f51090a54
https://pubmed.ncbi.nlm.nih.gov/36059135
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4
An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness
Autor: Sarah Gillemot, Erika Trompet, Robert Snoeck, Graciela Andrei, Dimitrios Topalis, Arturo Temblador
Publikováno v: Viruses
Volume 13
Issue 6
Viruses, Vol 13, Iss 985, p 985 (2021)
Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a mode
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f5bbd18ef8447cb2ee8e9a1d6ee6c
https://pubmed.ncbi.nlm.nih.gov/34073189
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5
Viral fitness of MHV-68 viruses harboring drug resistance mutations in the protein kinase or thymidine kinase
Autor: Dimitrios Topalis, Graciela Andrei, Erika Trompet, Sarah Gillemot, Robert Snoeck
Publikováno v: Antiviral research. 182
Murine γ-herpesvirus-68 (MHV-68), genetically and biologically related to human γ-herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus, can be easily propagated in vitro allowing drug resistance studies. Previously, we descr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a253f8ba1be4e0cc6222b7d8717a2ae0
https://pubmed.ncbi.nlm.nih.gov/32763314
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6
Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra
Autor: Graciela Andrei, Sarah Gillemot, Dimitri Topalis, Robert Snoeck
Publikováno v: Drug Resistance Updates. 37:1-16
Herpesviruses thymidine kinase (TK) and protein kinase (PK) allow the activation of nucleoside analogues used in anti-herpesvirus treatments. Mutations emerging in these two genes often lead to emergence of drug-resistant strains responsible for life
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa586f0d68fa6040c31156bc29603ca8
https://doi.org/10.1016/j.drup.2018.01.003
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7
The Anti–Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase
Autor: Graciela Andrei, Dimitrios Topalis, Robert Snoeck, Sarah Gillemot
Publikováno v: The Journal of Infectious Diseases. 217:790-801
Background Genital herpes is an important cofactor for acquisition of human immunodeficiency virus (HIV) infection, and effective prophylaxis is a helpful strategy to halt both HIV and herpes simplex virus (HSV) transmission. The antiretroviral agent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569e9f18f76da99db6585303cd89c637
https://doi.org/10.1093/infdis/jix605
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8
Persistent primary cytomegalovirus infection in a kidney transplant recipient: Multi-drug resistant and compartmentalized infection leading to graft loss
Autor: Katrien Lagrou, Bert Bammens, Pierre Fiten, Sarah Gillemot, Jasper Victoor, Ben Sprangers, Ghislain Opdenakker, Björn Meijers, Dirk Kuypers, Robert Snoeck, Elisabet Van Loon, Evelyne Lerut, Graciela Andrei, Maarten Naesens
Publikováno v: Antiviral research. 168
Cytomegalovirus (CMV) is one of the most common opportunistic infections after transplantation. To prevent CMV infections, universal prophylaxis and pre-emptive therapy with ganciclovir or its prodrug valganciclovir is applied. However, prolonged ant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb984709f2fa1b76b489e60ffdaf665
https://pubmed.ncbi.nlm.nih.gov/31212020
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9
A European multi-centre External Quality Assessment (EQA) study on phenotypic and genotypic methods used for Herpes Simplex Virus (HSV) drug resistance testing
Autor: David Boutolleau, Graciela Andrei, Natasha Ohemeng-Kumi, Renata Piorkowska, Sonia Burrel, David F. Bibby, Jean L. Mbisa, Brendan Crowley, Robert Snoeck, Baharak Afshar, Florence Morfin, Emilie Frobert, Sarah Gillemot
Publikováno v: Journal of Clinical Virology
Journal of Clinical Virology, 2017, 96, pp.89-93. ⟨10.1016/j.jcv.2017.10.002⟩
Journal of Clinical Virology, Elsevier, 2017, 96, pp.89-93. ⟨10.1016/j.jcv.2017.10.002⟩
International audience; BACKGROUND: Herpes Simplex Virus (HSV) drug resistance is a significant public health concern among immunocompromised individuals. Phenotypic assays are considered the gold standard method for detecting HSV drug resistance. Ho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1065b495cacfe1c9516a867587cd0c9
https://pubmed.ncbi.nlm.nih.gov/29031157
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10
Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes
Autor: Christine Geron, Graciela Andrei, Lutz Bindl, Leon Bofferding, Pierre Fiten, Robert Snoeck, Christoph Neuhäuser, Ghislain Opdenakker, Manon Bache, Sarah Gillemot, Jean Bottu
Publikováno v: Journal of the Pediatric Infectious Diseases Society. 3:e24-e27
A neonate suffering from herpes simplex virus type 2 disease with central nervous system involvement developed an early recurrence under acyclovir therapy. Isolates from the cerebrospinal fluid and skin lesions were acyclovir resistant, while viruses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531996684131c888cfe7e19418a91b8c
https://doi.org/10.1093/jpids/pit045
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