Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sarah Gehrke"'
Autor:
Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and ne
Externí odkaz:
https://doaj.org/article/95a6bc7fc7a345f08d833daae479ee94
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Purpose:Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f50f1cb7f49b0786b023d0bffbc36a
https://doi.org/10.1158/1078-0432.c.6527879.v1
https://doi.org/10.1158/1078-0432.c.6527879.v1
Autor:
James DeGregori, Angelo D’Alessandro, Kirk C. Hansen, Craig T. Jordan, Biniam Adane, Sarah Gehrke, Vadym Zaberezhnyy, Hae J. Park, Travis Nemkov, Mark A. Gregory
Figure S1. The glutaminase inhibitor CB-839 impairs glutathione metabolism in FLT3WT AML cells. Figure S2. The glutaminase inhibitor CB-839 decreases glutathione levels, but does not increase total cellular ROS levels in AML cells. Figure S3. Antioxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49be6a43542813bd64bae76d97a7a934
https://doi.org/10.1158/1078-0432.22471412.v1
https://doi.org/10.1158/1078-0432.22471412.v1
Autor:
Ray Stefancsik, James P. Balhoff, Meghan A. Balk, Robyn Ball, Susan M. Bello, Anita R. Caron, Elissa Chessler, Vinicius de Souza, Sarah Gehrke, Melissa Haendel, Laura W. Harris, Nomi L. Harris, Arwa Ibrahim, Sebastian Koehler, Nicolas Matentzoglu, Julie A. McMurry, Christopher J. Mungall, Monica C. Munoz-Torres, Tim Putman, Peter Robinson, Damian Smedley, Elliot Sollis, Anne E Thessen, Nicole Vasilevsky, David O. Walton, David Osumi-Sutherland
Publikováno v:
bioRxiv
Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3ba90afc362ce02ed181cd277391e8
https://doi.org/10.1101/2023.01.26.525742
https://doi.org/10.1101/2023.01.26.525742
Autor:
David J. Orlicky, Karim C. El Kasmi, Mark A. Lovell, Swati Ghosh, Ronald J. Sokol, Aimee L. Anderson, Sarah Gehrke, Michael W. Devereaux, Julie A. Reisz, Colin T. Shearn, Angelo D'Alessandro
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Chronically administered parenteral nutrition (PN) in patients with intestinal failure carries the risk for developing PN-associated cholestasis (PNAC). We have demonstrated that farnesoid X receptor (FXR) and liver X receptor (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f891a063835002c199614ef64d3d2e
https://doi.org/10.1002/hep.32071
https://doi.org/10.1002/hep.32071
Autor:
Chaitanya R. Divgi, Tiffany Thomas, Debra Kessler, Travis Nemkov, Andrew Eisenberger, Angelo D'Alessandro, Yelena Ginzburg, Joseph E. Schwartz, Beth H. Shaz, Mark Soffing, Francesca Rapido, Julie A. Reisz, Steven L. Spitalnik, Eldad A. Hod, Sarah Gehrke, Arif Sheikh, Francesca La Carpia, Richard O. Francis, James C. Zimring, Esther Coronel, Randy Yeh
Publikováno v:
J Clin Invest
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95f021af508315c5fd25dd554a18d41
https://doi.org/10.1172/jci133530
https://doi.org/10.1172/jci133530
Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients
Autor:
Reed W. Kamyszek, Sarah Gehrke, Nirmish Shah, Angelo D'Alessandro, Fabia Gamboni, Alan Gray, Ian J. Welsby, Amudan J Srinivasan, Matthew D. Landrigan
Publikováno v:
Transfusion. 59:3102-3112
Background Red blood cell exchange (RCE) transfusions are a mainstay in the treatment of sickle cell anemia (SCA), and allow a temporary restoration of physiological parameters with respect to erythrocyte oxygen carrying capacity and systems metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf952f3060d4c09da5c1ad12b25dbec
https://doi.org/10.1111/trf.15467
https://doi.org/10.1111/trf.15467
Autor:
Sarah Gehrke, Hae J. Park, Vadym Zaberezhnyy, James DeGregori, Kirk C. Hansen, Biniam Adane, Mark A. Gregory, Angelo D'Alessandro, Craig T. Jordan, Travis Nemkov
Publikováno v:
Clin Cancer Res
Purpose: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d089603b84104eb32c9f4bc8ded63af
https://doi.org/10.1158/1078-0432.ccr-18-3223
https://doi.org/10.1158/1078-0432.ccr-18-3223
Autor:
Yingze Zhang, Julie A. Reisz, Sarah Gehrke, Jessica B. Badlam, Chenell Donadee, Michael G. Risbano, Angelo D'Alessandro, Tamir Kanias, Shilpa Jain, Mark T. Gladwin, Suchitra Barge, Darrell J. Triulzi, Keisha Alexander
Publikováno v:
Blood Advances. 3:884-896
Cold storage of blood for 5 to 6 weeks has been shown to impair endothelial function after transfusion and has been associated with measures of end-organ dysfunction. Although the products of hemolysis, such as cell-free plasma hemoglobin, arginase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905a10d7f426df8ca4b670b1b078e8f6
https://doi.org/10.1182/bloodadvances.2018029629
https://doi.org/10.1182/bloodadvances.2018029629
Autor:
Chaim Putterman, Peter Runge, Raquel Furtado, Angelo D'Alessandro, Kari Alitalo, Rajesh Kumar Soni, Giada Mondanelli, Simone Moretti, Sarah Gehrke, Sangeetha Thangaswamy, Wanxia Li Tsai, Giorgia Manni, Grégoire Lauvau, Sheila Spada, Laura Santambrogio, Massimo Gadina, Silvia C. Formenti, Cornelia Halin, Sandra Demaria, Marc Veldhoen, Cristina C. Clement, Roccaldo Sardella, Amanda P. Beck, Samantha A. Chalmers, Francesca Fallarino, Ursula Grohmann, Luisa C. López Cara, Jorge Arasa, Mihaela Skobe, Roberta Galarini, Antonio Macchiarulo, Marco Gargaro, Federica Ianni, Ruben Fernandez-Rodriguez, Sinem Karaman
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
instname
Nature Communications
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The work was supported by the following grants: NIH-AG045223 and NIH-AI137198 to L.S.; the Swiss National Science Foundation, grant 310030_182528 to C.H.; Telethon GGP17094 and the Associazione Italiana per la Ricerca sul Cancro (AIRC; 19903) to F.F.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e8892c2cb7a5974dc461a6be74451