Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Sarah G. Hymowitz"'
Autor:
Cholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine S. Huang, Jiansheng Wu, Diego Ellerman, Sarah G. Hymowitz, Benjamin Walters, Cleo Salisbury, Paul J. Carter
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific Ig
Externí odkaz:
https://doaj.org/article/7dd9a83f03f24159a13745cb1fdb0072
Autor:
Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
Publikováno v:
Nature, vol 609, iss 7926
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers1–3. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation4 of the kinase RAF remains limited. Recent structures of
Autor:
James J. Crawford, Jianwen Feng, Hans D. Brightbill, Adam R. Johnson, Matthew Wright, Aleksandr Kolesnikov, Wendy Lee, Georgette M. Castanedo, Steven Do, Nicole Blaquiere, Steven T. Staben, Po-Chang Chiang, Peter W. Fan, Matt Baumgardner, Susan Wong, Robert Godemann, Alice Grabbe, Catharina Wiegel, Swathi Sujatha-Bhaskar, Sarah G. Hymowitz, Nicholas Liau, Peter L. Hsu, Paul A. McEwan, Moulay Hicham Alaoui Ismaili, Matthew L. Landry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb21c9e6dbe8d70e0d41f1c745caf358
https://doi.org/10.2139/ssrn.4345205
https://doi.org/10.2139/ssrn.4345205
Autor:
Sarah G. Hymowitz, Jawahar Sudhamsu, John G. Quinn, Wilson Phung, Shiva Malek, Nicholas P. D. Liau, Avinashnarayan Venkatanarayan
Publikováno v:
Biochemistry. 59:3982-3992
The Ras-RAF-MEK-ERK signaling axis, commonly mutated in human cancers, is highly regulated to prevent aberrant signaling in healthy cells. One of the pathway modulators, 14-3-3, a constitutive dimer, induces RAF dimerization and activation by binding
Autor:
Cholpon Tilegenova, Sarah G. Hymowitz, Cleo M. Salisbury, Saeed Izadi, Jianping Yin, Christine S. Huang, Paul Carter, Diego Ellerman, Benjamin T. Walters, Jiansheng Wu
Publikováno v:
mAbs
Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific Ig
Autor:
Peter W. Fan, Sarah G. Hymowitz, Teresa Dong, Xingyu Lin, Zoe Zhong, Connie Chan, Paul A. McEwan, Wyne P. Lee, Swathi Sujatha-Bhaskar, Baihua Hu, Nicole Blaquiere, Jason Burch, Jianwen Feng, Hans Brightbill, Steven T. Staben, Alison J Hole, James J. Crawford, Guosheng Wu, Suzanne Brown, Moulay Hicham Alaoui Ismaili, Georgette Castanedo, Patrick Lee, Hoa Le, Leonid M. Berezhkovskiy, Po-Chang Chiang, Robert Godemann, Brent S. McKenzie, Emily B. Gogol, Hernani L Silvestre, Ning Liu, Eric Suto, Nico Ghilardi, Yamin Zhang, Lawren C. Wu, Alice Grabbe
Publikováno v:
Journal of Medicinal Chemistry. 61:6801-6813
NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation
Autor:
Robert Godemann, Kathleen Knüppel, Christian A.G.N. Montalbetti, Stefan Steinbacher, Myron Smith, Lawren C. Wu, Swathi Sujatha-Bhaskar, Jianwen Feng, Maureen Beresini, Jacob Z. Chen, Christine Everett, Pawan Bir Kohli, Susan Krüger, Joachim Kraemer, David A. Roberts, Sarah G. Hymowitz, Ryan Takahashi, Hans Brightbill, Paul A. McEwan, Nobuhiko Kayagaki, Yamin Zhang, Pui Loke, Georgette Castanedo, Charles Eigenbrot, Hai-Feng Cui, Nicole Blaquiere, Steven T. Staben, Brandon J. Bravo, Adam R. Johnson, Emily B. Gogol, Xiaolu Wang
Publikováno v:
Journal of Medicinal Chemistry. 60:627-640
We report here structure-guided optimization of a novel series of NF-κB inducing kinase (NIK) inhibitors. Starting from a modestly potent, low molecular weight lead, activity was improved by designing a type 11/2 binding mode that accessed a back po
Autor:
Matthew Wongchenko, Ayşegül Özen, Sarah G. Hymowitz, Yibing Yan, Christine Yu, John Mayfield, Nicholas J. Skelton, Jianping Yin, Charles Eigenbrot, Gabriele Schaefer, Daniel M. Whalen, Georgia Hatzivassiliou, Juliann Chmielecki, Gerard Manning, Scott A. Foster, Andrey S. Shaw, Shiva Malek, Ivana Yen, Philip J. Stephens, Lee A. Albacker, Kyung Song
Publikováno v:
Cancer Cell. 29:477-493
Activating mutations in protein kinases drive many cancers. While how recurring point mutations affect kinase activity has been described, the effect of in-frame deletions is not well understood. We show that oncogenic deletions within the β3-αC lo
Autor:
Sarah G. Hymowitz, Shiva Malek
Publikováno v:
Cold Spring Harb Perspect Med
Despite decades of extensive drug discovery efforts, there are currently no targeted therapies approved to treat KRAS mutant cancers. In this review, we highlight the challenges and opportunities in targeting KRAS mutant tumors through inhibition of
Autor:
Aaron C. Schmitt, Donna Dambach, Jen Macaluso, Kevin S. Currie, Xiaojing Wang, James Barbosa, Sarah G. Hymowitz, Kropf Jeffrey E, Steve Gallion, Peter Blomgren, Lichuan Liu, Scott A. Mitchell, Julie Di Paolo, Jin-Ming Xiong, Joseph W. Lubach, Pat Maciejewski, C. Gregory Sowell, Heleen Scheerens, Seung H. Lee, Karin Reif, Zhongdong Zhao, Wendy B. Young, Jianjun Xu, Harvey Wong, Brigitte Maurer, Daniel F. Ortwine, James J. Crawford, Meire Bremer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25(6):1333-1337
SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the potency and selectivity of CGI-1746, b