Výsledky vyhledávání - "Sarah G Francisco"

Akademický článek

Glyoxalase System as a Therapeutic Target against Diabetic Retinopathy

Autor: Gemma Aragonès, Sheldon Rowan, Sarah G Francisco, Wenxin Yang, Jasper Weinberg, Allen Taylor, Eloy Bejarano

Publikováno v: Antioxidants, Vol 9, Iss 11, p 1062 (2020)

Hyperglycemia, a defining characteristic of diabetes, combined with oxidative stress, results in the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that have adverse effects on many tissues including the retina and lens

Externí odkaz: https://doaj.org/article/c35aadbbe6f74defa29ae874154bfa17

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Akademický článek

Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

Autor: Anupam K. Mondal, Daniel C. Brock, Sheldon Rowan, Zhi-Hong Yang, Krishna Vamsi Rojulpote, Kelsey M. Smith, Sarah G. Francisco, Eloy Bejarano, Milton A. English, Amy Deik, Sarah Jeanfavre, Clary B. Clish, Alan T. Remaley, Allen Taylor, Anand Swaroop

Publikováno v: iScience, Vol 27, Iss 2, Pp 108979- (2024)

Summary: A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In

Externí odkaz: https://doaj.org/article/b13e6864cc514103b6dadb00ab4c518b

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Akademický článek

The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy

Autor: Gemma Aragonès, Sheldon Rowan, Sarah G. Francisco, Elizabeth A. Whitcomb, Wenxin Yang, Giuliana Perini-Villanueva, Casper G. Schalkwijk, Allen Taylor, Eloy Bejarano

Publikováno v: Cells, Vol 10, Iss 8, p 1852 (2021)

The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycati

Externí odkaz: https://doaj.org/article/4952ec86a10c4e1eb7a448087ba35769

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A reciprocal translocation involving Aspergillus nidulans snxAHrb1/Gbp2 and gyfA uncovers a new regulator of the G2–M transition and reveals a role in transcriptional repression for the setBSet2 histone H3-lysine-36 methyltransferase

Autor: Steven W James, Jonathan Palmer, Nancy P Keller, Morgan L Brown, Matthew R Dunworth, Sarah G Francisco, Katherine G Watson, Breanna Titchen, Alecia Achimovich, Andrew Mahoney, Joseph P Artemiou, Kyra G Buettner, Madelyn Class, Andrew L Sydenstricker, Sarah Lea Anglin

Publikováno v: Genetics. 222

Aspergillus nidulans snxA, an ortholog of Saccharomyces cerevisiae Hrb1/Gbp2 messenger RNA shuttle proteins, is—in contrast to budding yeast—involved in cell cycle regulation, in which snxA1 and snxA2 mutations as well as a snxA deletion specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7930f900e18e8c63c08f33fb85dfeb7b
https://doi.org/10.1093/genetics/iyac130

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Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts

Autor: Sheldon Rowan, Shuhong Jiang, Sarah G. Francisco, Laura C. D. Pomatto, Zhiwei Ma, Xiaodong Jiao, Maria M. Campos, Sandeep Aryal, Shaili D. Patel, Binapani Mahaling, S. Amer Riazuddin, Elia J. Duh, Salil A. Lachke, J. Fielding Hejtmancik, Rafael de Cabo, Paul G. FitzGerald, Allen Taylor

Publikováno v: Investigative ophthalmology & visual science, vol 62, iss 15
Investigative Ophthalmology & Visual Science

Purpose Age-related cataracts affect the majority of older adults and are a leading cause of blindness worldwide. Treatments that delay cataract onset or severity have the potential to delay cataract surgery, but require relevant animal models that r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfc6180f7e42f5e7785cd513a215d47
https://escholarship.org/uc/item/3d327405

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Modifying the Gut Microbiome Through Diet or Antibiotics Alters Bone Phenotypes in Older Mice

Autor: Kelsey Smith, Chia-Fang Tsai, Sarah G Francisco, Jacob C. Nixon, Kathryn Barger, Donald Smith, Christopher J. Hernandez, Sheldon Rowan, Macy Castaneda

Publikováno v: Curr Dev Nutr

OBJECTIVES: Gut microbiota have been shown to influence bone quality and quantity, both risk determinants for osteoporosis. Previous research in young mice showed oral antibiotic treatment during rapid bone gain impaired bone tissue quality. We sough

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197ea4c994305a198f1e8a3febcfdf56
https://europepmc.org/articles/PMC8181326/

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The glyoxalase system in age-related diseases: nutritional intervention as anti-ageing strategy

Autor: Elizabeth A. Whitcomb, Sheldon Rowan, Wenxin Yang, Giuliana Perini-Villanueva, Gemma Aragonès, Sarah G Francisco, Eloy Bejarano, Casper G. Schalkwijk, Allen Taylor

Publikováno v: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
Cells
Cells, Vol 10, Iss 1852, p 1852 (2021)

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2073-4409/10/8/1852 En este artículo también participan: Casper G. Schalkwijk y Allen Taylor. Este artículo pertenece al número especial "Mechanisms of Aging and The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee37dad342d324da2e31df8b7776d3cb
https://doi.org/10.3390/cells10081852

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Glyoxalase system as a therapeutic target against diabetic retinopathy

Autor: Wenxin Yang, Sarah G Francisco, Sheldon Rowan, Jasper Weinberg, Allen Taylor, Eloy Bejarano, Gemma Aragonès

Publikováno v: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
Antioxidants, Vol 9, Iss 1062, p 1062 (2020)
Antioxidants

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-3921/9/11/1062 Este artículo pertenece al número especial "Oxidative stress in diabetic retinopathy". Hyperglycemia, a defining characteristic of diabetes, combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8a4da95f959a1724ad546067dab87c
http://hdl.handle.net/10637/12540

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Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
instname
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
Digital.CSIC. Repositorio Institucional del CSIC
Aging Cell
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)

Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars or their metabolites react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a66753153f762501e685cfc80154b1f

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