Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah Freemantle"'
Autor:
Eungi Yang, Ofelia Tacchelly-Benites, Zhenghan Wang, Michael P. Randall, Ai Tian, Hassina Benchabane, Sarah Freemantle, Claudio Pikielny, Nicholas S. Tolwinski, Ethan Lee, Yashi Ahmed
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Wnt/β-catenin signalling directs several developmental processes and is aberrantly activated in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein Axin for proteolysis—in early Wnt signalling
Externí odkaz:
https://doaj.org/article/3da63aa64149454db576577367439463
Autor:
Ethan Dmitrovsky, Sarah Freemantle, Duane A. Compton, David Sekula, Masanori Kawakami, Lisa Maria Mustachio, Kristina Godek, Bernardo Orr, Yun Lu, Shanhu Hu
Knock-down of Usp33 in murine lung cancer cells does not affect CP110 protein expression. Effects of Usp33 knock-down at 24,48, 72 and 96 hours on CP110 expression in ED-1 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df3c9b4dab96bc8e6fe93915d34e495
https://doi.org/10.1158/1535-7163.22505949
https://doi.org/10.1158/1535-7163.22505949
Autor:
Ethan Dmitrovsky, Sarah Freemantle, Duane A. Compton, David Sekula, Masanori Kawakami, Lisa Maria Mustachio, Kristina Godek, Bernardo Orr, Yun Lu, Shanhu Hu
The siRNA sequences used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f3ad6395ab4607ef514ac579c22f1f
https://doi.org/10.1158/1535-7163.22505943
https://doi.org/10.1158/1535-7163.22505943
Autor:
Ethan Dmitrovsky, Sarah Freemantle, David Sekula, Xi Liu, Fabrizio Galimberti, Tian Ma, Robert Gallagher, Da-Cheng Zhou, Eugene Demidenko, Jennifer M. Bomberger, Bruce Stanton, Fadzai Chinyengetere, Andrey V. Dolinko, Yongli Guo
Supplementary Figure 1 from Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RARα and Inhibits the Growth of Acute Promyelocytic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2013623415d1e664e5ed610b9d2ee077
https://doi.org/10.1158/0008-5472.22386936
https://doi.org/10.1158/0008-5472.22386936
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Supplemental File S1. The siRNA sequences and real-time qPCR primer sequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b862a22918b39e67b0c3690881f8c08b
https://doi.org/10.1158/0008-5472.22405371.v1
https://doi.org/10.1158/0008-5472.22405371.v1
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Supplemental File S2. A representative video of a Hop62 cell that undergoes multipolar cell division.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184a98750323422e07f93ea48161714a
https://doi.org/10.1158/0008-5472.22405368
https://doi.org/10.1158/0008-5472.22405368
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacologic targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. We previously dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f9044b04e6c905e9ed4e1a0588b340
https://doi.org/10.1158/0008-5472.c.6506817.v1
https://doi.org/10.1158/0008-5472.c.6506817.v1
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Supplemental Fig. S3. (A) Schematic diagram showing the relationship between CDK2, CP110, activated KRAS and anaphase catastrophe. (B) Engineered overexpression of CP110 was detected in A549, Hop62, H522 and H460 cells (versus control transfectants)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bdc0b4475e6ebf65064d6d97865383
https://doi.org/10.1158/0008-5472.22405383.v1
https://doi.org/10.1158/0008-5472.22405383.v1
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Supplemental Fig. S5. Representative CP110 immunohistochemistry staining of lung normal (N) versus malignant (T) tissues harvested independently from KRAS wild-type transgenic mice and KRAS mutant transgenic mice.The table displays KRAS mutation info
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb3d10153a0c09e9657da1207b3d3a
https://doi.org/10.1158/0008-5472.22405374
https://doi.org/10.1158/0008-5472.22405374
Autor:
Ethan Dmitrovsky, Duane A. Compton, Sarah Freemantle, Ignacio I. Wistuba, Angeline S. Andrew, David Sekula, Yun Lu, Andrew DeCastro, Saranya Ravi, Fabrizio Galimberti, Lisa Maria Mustachio, Vincent A. Memoli, Cesar A. Moran, Barbara Mino, Carmen Behrens, Jaime Rodriguez-Canales, Laura J. Tafe, Bernardo Orr, Kristina Godek, Alexey V. Danilov, Shanhu Hu
Supplemental Fig. S4. (A) Effect of engineered KRAS expression on response to CDK2 inhibition by seliciclib. KRAS mutation sensitized lung cancer cells towards seliciclib-mediated CDK2 inhibition of growth as compared to control-ED-1 cells. (B) Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b194395a6de472173183726165ec9
https://doi.org/10.1158/0008-5472.22405377
https://doi.org/10.1158/0008-5472.22405377