Stakeholders’ perspectives on clinical trial acceptability and approach to consent within a limited timeframe: a mixed methods study

Autor: Matthew Peak, Michael Griksaitis, Clare Fowler, Simon Gates, Christopher Lamb, Elizabeth Deja, Rachel Agbeko, John Pappachan, Helen Parker, Jennifer Preston, Ahmed Osman, Paula Williamson, Paul S McNamara, David Armstrong, Tracy Moitt, Ramesh Kumar, John Alexander, Kevin P Morris, Roger Parslow, Steve Cunningham, Craig Knott, Chloe Donohue, Catrin Barker, Julie Richardson, Ashley Jones, Stephanie Clarke, Malcolm G Semple, Richard Levin, James Weitz, Natasha Roberts, Vanessa Compton, Kentigern Thorburn, PHILIP MILNER, Howard W Clark, Bessie Cipriano, Nosheen Khalid, Nicolene Plaatjies, Avishay Sarfatti, Mark Terris, Santosh Sundararajan, Edgar Brincat, Natasha Thorn, Ramiya Kirupananthan, Peter J Davis, Samantha Owen, Pavanasam Ramesh, Sarah Fox, Laura Price, Hannah Clarke, Charlotte Thompson, Wendy Browne, Christine Mackerness, Laura Rad, Grace Williamson, Simone Paulson, Laura O'Malley, Zoe Oliver, Evette Allen, Clare van Miert, Ashley Best, Jens Madsen, Anne Dawson, Colin Summers, Blessing Osaghae, Madhuri Panchal, Anthony Postle, Peter Jirasek, Dawn Jones, Michael Mander, Laura Rimmer, Paul C Ritson, Chris Simons, Afeda Mohamed Ali, Cara Alexander, Hannah Child, Natalie Milburn, Holly Parkin, Harriet Payne, Carly Tooke, Helen Winmill, Katherine Baptiste, Sophie Coles, Sarah-Jayne Eames, Christina Linton, Helen Marley, Sarah Mogan, Alvin Schadenberg, John Stiven, Rob Claydon, Anna Stancombe, Kate Teeley, Kathryn Reeves, Emily Scriven, Raghu N Ramaiah, Rekha Patel, Patrick E Davies, Lindsay Crate, Kirsten Beadon, Rachel McMinnis, Frances Sinfield, Hilary Callaghan, Vicki Linton, Jeremy Lyons, Clara Nelson, Tsz-YanMilly Lo, Jackie McCormick, Andrea Wood, Ross Marscheider, Stephen D Playfor, Bernadette C Gavin, Dave J Morgan, Lara T Bunni, Claire F Jennings, Rebecca Marshall, Emma K Riley, Lorena Caruana, Amber Cook, Tracey Curtis, Nichola Etherington, Jenni McCorkell, Christie Mellish, Jenny Pond, Catherine Postlethwaite, Nicola McClelland, Holly Minchin, Joanne Tomlinson, Simona Lampariello, Tara Murray, Olivia Nugent, Samantha Reed, Christa Ronan, Salman Siddiqi

Publikováno v: BMJ Open, Vol 14, Iss 1 (2024)

Objectives The Bronchiolitis Endotracheal Surfactant Study (BESS) is a randomised controlled trial to determine the efficacy of endo-tracheal surfactant therapy for critically ill infants with bronchiolitis. To explore acceptability of BESS, includin

Externí odkaz: https://doaj.org/article/3170ef8f62a14d658eb8ae20a8d2b6ee

Frailty and solid-organ transplant candidates: a scoping review

Autor: Jonathan Kao, Natasha Reid, Ruth E Hubbard, Ryan Homes, Leila Shafiee Hanjani, Ella Pearson, Benignus Logan, Shannon King, Sarah Fox, Emily H Gordon

Publikováno v: BMC Geriatrics, Vol 22, Iss 1, Pp 1-13 (2022)

Abstract Background There is currently no consensus as to a standardized tool for frailty measurement in any patient population. In the solid-organ transplantation population, routinely identifying and quantifying frailty in potential transplant cand

Externí odkaz: https://doaj.org/article/b3a86732d51f445988e744d9d21b4dd6

Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β–related pathway in macrophages

Autor: Lynda Zeboudj, George Sideris-Lampretsas, Rita Silva, Sabeha Al-Mudaris, Francesca Picco, Sarah Fox, David Chambers, Marzia Malcangio

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)

Neuropathic pain remains poorly managed by current therapies, highlighting the need to improve our knowledge of chronic pain mechanisms. In neuropathic pain models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracellul

Externí odkaz: https://doaj.org/article/fc2220f0626b4bac8a735b3fa93c7709

CD206+/MHCII− macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease

Autor: Rita Silva, George Sideris-Lampretsas, Sarah Fox, Lynda Zeboudj, Marzia Malcangio

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100548- (2022)

Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms of chronic pain in this neurodegenerative disease is essential. Neuropathic pain and AD share a significant involvement of the

Externí odkaz: https://doaj.org/article/f3db516596c3475e9d4089254ce6a88d

Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study

Autor: Sarah Fox, Laura J E Brown, Steven Antrobus, David Brough, Richard J Drake, Francine Jury, Iracema Leroi, Adrian R Parry-Jones, Matthew Machin

Publikováno v: JMIR mHealth and uHealth, Vol 10, Iss 1, p e24483 (2022)

BackgroundThe benefits of involving those with lived experience in the design and development of health technology are well recognized, and the reporting of co-design best practices has increased over the past decade. However, it is important to reco

Externí odkaz: https://doaj.org/article/8b16e56520874b1cbde4222d2871a419