Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarah Farrington"'
Autor:
GuangJun Zhang, Sebastian Hoersch, Adam Amsterdam, Charles A Whittaker, Eline Beert, Julian M Catchen, Sarah Farrington, John H Postlethwait, Eric Legius, Nancy Hopkins, Jacqueline A Lees
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003734 (2013)
The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we demonstrated that zebrafish
Externí odkaz:
https://doaj.org/article/1c783a794bad449d9d72a5c16f434209
Autor:
Adam Amsterdam, Kirsten C Sadler, Kevin Lai, Sarah Farrington, Roderick T Bronson, Jacqueline A Lees, Nancy Hopkins
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E139 (2004)
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality an
Externí odkaz:
https://doaj.org/article/d6d910178d9841e4ae696fc8d8626993
Autor:
Eric C. Swindell, Zhaoxia Sun, Robert M. Nissen, Nancy Hopkins, Adam Amsterdam, Sarah Farrington
Publikováno v:
Proceedings of the National Academy of Sciences. 101:12792-12797
We completed a large insertional mutagenesis screen in zebrafish to identify genes essential for embryonic and early larval development. We isolated 525 mutants, representing lesions in approximately 390 different genes, and we cloned the majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4297847c087c757b48b99eb6656a75
https://doi.org/10.1073/pnas.0403929101
https://doi.org/10.1073/pnas.0403929101
Autor:
Zhaoxia Sun, Marcelo Antonelli, Nancy Hopkins, Shawn M. Burgess, Robert M. Nissen, Sarah Farrington, Shuh-Yow Lin, Gregory Golling, Adam Amsterdam, Wenbiao Chen, Maryann Haldi, Ernesto Maldonado, Karen Artzt
Publikováno v:
Nature Genetics. 31:135-140
To rapidly identify genes required for early vertebrate development, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as the mutagen. We will obtain mutations in 450 to 500 different genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c8b82f4caa2fd7238ffb681ee766e7
https://doi.org/10.1038/ng896
https://doi.org/10.1038/ng896
Autor:
Nancy Hopkins, Charles A. Whittaker, John H. Postlethwait, Sarah Farrington, Jacqueline A. Lees, GuangJun Zhang, Adam Amsterdam, Sebastian Hoersch, Julian M. Catchen, Eric Legius, Eline Beert
Publikováno v:
PLoS
PLoS Genetics, Vol 9, Iss 8, p e1003734 (2013)
PLoS Genetics 9 (8): e1003734.
PLoS Genetics
PLoS Genetics, Vol 9, Iss 8, p e1003734 (2013)
PLoS Genetics 9 (8): e1003734.
PLoS Genetics
The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we demonstrated that zebrafish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c2985fe9a27853c1b47504f76d4b76
https://orcid.org/0000-0001-9451-2194
https://orcid.org/0000-0001-9451-2194
Autor:
Kevin Lai, Jacqueline A. Lees, Adam Amsterdam, Nancy Hopkins, Roderick T. Bronson, Sarah Farrington
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 238(1)
We have characterized 28 zebrafish lines with heterozygous mutations in ribosomal protein (rp) genes, and found that 17 of these are prone to develop zebrafish malignant peripheral nerve sheath tumors (zMPNST). Heterozygotes from the vast majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8742dbf0645f4b3579089f0942e35d88
https://pubmed.ncbi.nlm.nih.gov/19097187
https://pubmed.ncbi.nlm.nih.gov/19097187
Autor:
Nancy Hopkins, Roderick T. Bronson, Jacqueline A. Lees, Adam Amsterdam, Kirsten C. Sadler, Sarah Farrington, Kevin Lai
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E139 (2004)
PLoS Biology
PLoS Biology
We have generated several hundred lines of zebrafish (Danio rerio), each heterozygous for a recessive embryonic lethal mutation. Since many tumor suppressor genes are recessive lethals, we screened our colony for lines that display early mortality an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43269e6c9bd480339b5bab0e9679aba4
http://europepmc.org/articles/PMC406397?pdf=render
http://europepmc.org/articles/PMC406397?pdf=render
Autor:
Wenbiao Chen, Shawn M. Burgess, Maryann Haldi, Sarah Farrington, Karen Townsend, Gregory Golling, Adam Amsterdam, Nancy Hopkins, Zhaoxia Sun
It is estimated that approximately 2500 genes are essential for the normal development of a zebrafish embryo. A mutation in any one of these genes can result in a visible developmental defect, usually followed by the death of the embryo or larva by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4433e27208d9214365afe4967c527d50
https://europepmc.org/articles/PMC317115/
https://europepmc.org/articles/PMC317115/