Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sarah Farooq"'
Autor:
Angela Inglis, Rosario Ubungen, Sarah Farooq, Princess Mata, Jennifer Thiam, Soad Saleh, Sherin Shibin, Futwan A. Al-Mohanna, Kate S. Collison
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background The ever-increasing prevalence of diabetes and associated comorbidities serves to highlight the necessity of biologically relevant small-animal models to investigate its etiology, pathology and treatment. Although the C57BL/6 J mo
Externí odkaz:
https://doaj.org/article/30e354ae34004166be3b788df7c73e40
Publikováno v:
Circulation. 145
Introduction: Compensatory hyperinsulinemia (CH) is the heightened response of thepancreas and liver to early insulin resistance. Elevated blood insulin compensates for insulin resistance in tissues, maintainingfasting glucose, triglycerides and HDL-
Autor:
Alan D. D'Andrea, Erica L. Mayer, Joyce F. Liu, Shannon N. Westin, Bose Kochupurakkal, Sarah Farooq, William T. Barry, Karen Cadoo, Lewis C. Cantley, Scott H. Kaufmann, Gerburg M. Wulf, Geoffrey I. Shapiro, Paul Kirschmeier, Panagiotis A. Konstantinopoulos, Gordon B. Mills, Ursula A. Matulonis, Eric P. Winer, Weixiu Luo, Robert L. Coleman, Julia Eismann, Sangeetha Palakurthi, Carol Aghajanian, Roisin E. O'Cearbhaill, Michael J. Birrer, Jennifer Curtis, Elizabeth M. Swisher, Christin Whalen, Mary K. Buss
Publikováno v:
The Lancet Oncology. 20:570-580
Summary Background Based on preclinical work, we found that combination of poly (ADP-ribose) polymerase (PARP) inhibitors with drugs that inhibit the homologous recombination repair (HRR) pathway (such as PI3K inhibitors) might sensitise HRR-proficie
Autor:
Kate S. Collison, Rosario Ubungen, Princess Mata, Sherin Shibin, Angela Inglis, Futwan Al-Mohanna, Sarah Farooq, Soad Saleh, Jennifer Thiam
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
Background The ever-increasing prevalence of diabetes and associated comorbidities serves to highlight the necessity of biologically relevant small-animal models to investigate its etiology, pathology and treatment. Although the C57BL/6 J model is am
Autor:
Gerburg M. Wulf, Tatum Spagnoletti, Gordon B. Mills, Helen Won, Carol Aghajanian, Lewis C. Cantley, Shannon N. Westin, Sangeetha Palakurthi, David B. Solit, Ursula A. Matulonis, Christin Whalen, Hui Liu, Elizabeth Obermayer, EP Winer, R.C. Hok, Michael F. Berger, Weixiu Luo, Barry S. Taylor, Joyce F. Liu, K.M. Bell-McGuinn, Michael J. Birrer, Sarah Farooq, William T. Barry
Publikováno v:
Annals of Oncology. 28:512-518
Background Based upon preclinical synergy in murine models, we carried out a phase I trial to determine the maximum tolerated dose (MTD), toxicities, pharmacokinetics, and biomarkers of response for the combination of BKM120, a PI3K inhibitor, and ol
Autor:
Shannon Puhalla, Kimberly L. Blackwell, Eric P. Winer, Alarice C. Lowe, Roisin M. Connolly, Kenneth R. Hess, N. Ryabin, Nathalie Y. R. Agar, Jeffrey S. Wefel, Christina I. Herold, Nan Lin, Sarah Farooq, Polly A. Niravath, Mothaffar F. Rimawi, Elizabeth V. Lawler, Ian E. Krop, Nuhad K. Ibrahim, Rachel A. Freedman, Catherine Van Poznak, Minetta C. Liu, Beverly Moy, Michelle E. Melisko, Antonio C. Wolff, Rebecca Gelman
Publikováno v:
Journal of Clinical Oncology. 34:945-952
Purpose Evidence-based treatments for metastatic, human epidermal growth factor receptor 2 (HER2)–positive breast cancer in the CNS are limited. Neratinib is an irreversible inhibitor of erbB1, HER2, and erbB4, with promising activity in HER2-posit
Autor:
Carolyn N. Krasner, Joyce F. Liu, William H. Barry, Gini F. Fleming, Stephen A. Cannistra, Panagiotis A. Konstantinopoulos, Sarah Farooq, Weixiu Luo, Ursula A. Matulonis, Mary K. Buss, Michael J. Birrer, Susan Schumer, Richard T. Penson, Elizabeth H. Stover, Alexi A. Wright, Susana M. Campos, Don S. Dizon
Publikováno v:
Gynecologic Oncology. 149:24-25
Autor:
Sarah Farooq, Kate S. Collison, Rosario Ubungen, Jennifer Thiam, Sherin Shibin, Futwan Al-Mohanna, Princess Mata, Angela Inglis
Publikováno v:
Physiology & Behavior. 210:112646
Introduction Small-animal models are the most widely used preclinical model for studying the etiology, pathology and treatment of diabetes, prediabetes and diabetic comorbidities. Diabetic patients are burdened with higher rates of depression, anxiet
Autor:
Neil S. Horowitz, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos, Don S. Dizon, Weixiu Luo, Sarah Farooq, Richard T. Penson, Alexi A. Wright, Elizabeth H. Stover, Joyce F. Liu, William H. Barry, Mark A. Hoffman, Susana M. Campos, Carolyn N. Krasner
Publikováno v:
Gynecologic Oncology. 149:24
Autor:
Geoffrey I. Shapiro, Ursula A. Matulonis, Deborah K. Armstrong, Nancy Chan, Richard T. Penson, Sarah Farooq, S. Percy Ivy, Joyce F. Liu, Alexander B. Olawaiye, James L. Abbruzzese, Andrea E. Wahner Hendrickson, Eliezer M. Van Allen, Robert M. Wenham, Jung-Min Lee, David E. Cohn, William T. Barry, Mihaela C. Cristea, Elise C. Kohn, Elizabeth M. Swisher, Koji Matsuo
Publikováno v:
Journal of Clinical Oncology. 36:5519-5519
5519Background: The combination of cediranib (ced) and olaparib (olap) improves progression-free survival and overall response rates (ORR) in women with recurrent plat sensitive high-grade serous (...