Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sarah Falk"'
Autor:
Camilla Lund, Pablo Ranea-Robles, Sarah Falk, Dylan M. Rausch, Grethe Skovbjerg, Victoria Kamma Vibe-Petersen, Nathalie Krauth, Jacob Lercke Skytte, Vasiliki Vana, Urmas Roostalu, Tune H. Pers, Jens Lund, Christoffer Clemmensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain. Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and prolonged inhibition of voluntary food intake following overfeedin
Externí odkaz:
https://doaj.org/article/149adc83ffa04fb0a50fbe581eab9297
Autor:
Anders B. Klein, Trine S. Nicolaisen, Niels Ørtenblad, Kasper D. Gejl, Rasmus Jensen, Andreas M. Fritzen, Emil L. Larsen, Kristian Karstoft, Henrik E. Poulsen, Thomas Morville, Ronni E. Sahl, Jørn W. Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K. Pedersen, Wei Lu, Brian Finan, Sebastian B. Jørgensen, Randy J. Seeley, Maximilian Kleinert, Bente Kiens, Erik A. Richter, Christoffer Clemmensen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food
Externí odkaz:
https://doaj.org/article/8f1d9eea4091471ca84ea46086fb7636
Autor:
Camilla Kristine Appel, Simone Gallego-Pedersen, Line Andersen, Sophie Blancheflor Kristensen, Ming Ding, Sarah Falk, Manasi Sayilekshmy, Charlotte Gabel-Jensen, Anne-Marie Heegaard
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Pain is a severe and debilitating complication of metastatic bone cancer. Current analgesics do not provide sufficient pain relief for all patients, creating a great need for new treatment options. The Src kinase, a non-receptor protein tyro
Externí odkaz:
https://doaj.org/article/8a2be61aace84981bb8033b783094820
Autor:
Michael S. Minett, Sarah Falk, Sonia Santana-Varela, Yury D. Bogdanov, Mohammed A. Nassar, Anne-Marie Heegaard, John N. Wood
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 301-312 (2014)
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice and humans. We examined the role of Nav1.7 as well as Nav1.3, Nav1.8, and Nav1.9 in different mouse models of chronic pain. Constriction-injury-depe
Externí odkaz:
https://doaj.org/article/7573c1aad53d411887931726ea7c84fb
Publikováno v:
F1000Research, Vol 4 (2015)
An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to mo
Externí odkaz:
https://doaj.org/article/d9dff7cb3d244071905bf870b703cd28
Publikováno v:
Journal of Osteoporosis, Vol 2012 (2012)
Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. The recent development of specific animal models has increased th
Externí odkaz:
https://doaj.org/article/e37f26d873c649ce85e3343561d503bc
Autor:
Jens Lund, Alberte Wollesen Breum, Cláudia Gil, Sarah Falk, Frederike Sass, Marie Sophie Isidor, Oksana Dmytriyeva, Pablo Ranea-Robles, Cecilie Vad Mathiesen, Astrid Linde Basse, Olivia Sveidahl Johansen, Nicole Fadahunsi, Camilla Lund, Trine Sand Nicolaisen, Anders Bue Klein, Tao Ma, Brice Emanuelli, Maximilian Kleinert, Charlotte Mehlin Sørensen, Zachary Gerhart-Hines, Christoffer Clemmensen
Publikováno v:
Nature Metabolism. 5:677-698
Autor:
Sarah Falk, Jonas Petersen, Charlotte Svendsen, Cesar R. Romero-Leguizamón, Søren Heide Jørgensen, Nathalie Krauth, Mette Q. Ludwig, Kathrine Lundø, Urmas Roostalu, Grethe Skovbjerg, Duy Anh Gurskov Nielsen, Aske Lykke Ejdrup, Tune H. Pers, Oksana Dmytriyeva, Jacob Hecksher-Sørensen, Ulrik Gether, Kristi A. Kohlmeier, Christoffer Clemmensen
Publikováno v:
Falk, S, Petersen, J O, Svendsen, C S A, Leguizamon, C R R, Jørgensen, S H, Krauth, N, Ludwig, M Q, Lundø, K, Roostalu, U, Hjort-Gregersen, G S, Nielsen, D A G, Ejdrup, A L, Pers, T H, Dmytriyeva, O, Hecksher-Soerensen, J, Gether, U, Kohlmeier, K A & Clemmensen, C 2023, ' GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity ', Cell Reports, vol. 42, no. 5, 112466 . https://doi.org/10.1016/j.celrep.2023.112466
Glucagon-like peptide-1 receptor (GLP-1R) agonists promote nicotine avoidance. Here, we show that the crosstalk between GLP-1 and nicotine extends beyond effects on nicotine self-administration and can be exploited pharmacologically to amplify the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e039f98ee08a450e7a8844a6cc07ce38
https://curis.ku.dk/ws/files/346487639/1_s2.0_S2211124723004771_main.pdf
https://curis.ku.dk/ws/files/346487639/1_s2.0_S2211124723004771_main.pdf
Autor:
Sarah Falk, Eva Maria Meier Carlsen, Giovanni Marsicano, Antonio C Pagano Zottola, Laurie M. Robin, Urszula Skupio, Jean-François Perrier
Publikováno v:
Nature neuroscience
Cannabinoids reduce tremor associated with motor disorders induced by injuries and neurodegenerative disease. Here we show that this effect is mediated by cannabinoid receptors on astrocytes in the ventral horn of the spinal cord, where alternating l
Autor:
Mark Lyngbæk, Rasmus Jensen, Andreas M. Fritzen, Anders B. Klein, Sarah Falk, Niels Ørtenblad, Christoffer Clemmensen, Henrik E. Poulsen, Ronni E. Sahl, Maximilian Kleinert, Jens Lund, Randy J. Seeley, Emil List Larsen, Kasper Degn Gejl, Brian Finan, Bente Klarlund Pedersen, Jørn Wulff Helge, Helga Ellingsgaard, Erik A. Richter, Bente Kiens, Trine S. Nicolaisen, Kristian Karstoft, Sebastian Beck Jørgensen, Wei Lu, Thomas Morville
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Klein, A B, Nicolaisen, T S, Ørtenblad, N, Gejl, K D, Jensen, R, Fritzen, A M, Larsen, E L, Karstoft, K, Poulsen, H E, Morville, T, Sahl, R E, Helge, J W, Lund, J, Falk, S, Lyngbæk, M, Ellingsgaard, H, Pedersen, B K, Lu, W, Finan, B, Jørgensen, S B, Seeley, R J, Kleinert, M, Kiens, B, Richter, E A & Clemmensen, C 2021, ' Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise ', Nature Communications, vol. 12, 1041 . https://doi.org/10.1038/s41467-021-21309-x
Nat. Commun. 12:1041 (2021)
Nature Communications
Klein, A B, Nicolaisen, T S, Ørtenblad, N, Gejl, K D, Jensen, R, Fritzen, A M, Larsen, E L, Karstoft, K, Poulsen, H E, Morville, T, Sahl, R E, Helge, J W, Lund, J, Falk, S, Lyngbæk, M, Ellingsgaard, H, Pedersen, B K, Lu, W, Finan, B, Jørgensen, S B, Seeley, R J, Kleinert, M, Kiens, B, Richter, E A & Clemmensen, C 2021, ' Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise ', Nature Communications, vol. 12, 1041 . https://doi.org/10.1038/s41467-021-21309-x
Nat. Commun. 12:1041 (2021)
Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely,