Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Sarah F. Andrews"'
Autor:
Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leuk
Externí odkaz:
https://doaj.org/article/086e3f3dbf7c436b9fc0aa65fce2326a
Autor:
Yuhe R. Yang, Julianna Han, Hailee R. Perrett, Sara T. Richey, Alesandra J. Rodriguez, Abigail M. Jackson, Rebecca A. Gillespie, Sarah O’Connell, Julie E. Raab, Lauren Y. Cominsky, Ankita Chopde, Masaru Kanekiyo, Katherine V. Houser, Grace L. Chen, Adrian B. McDermott, Sarah F. Andrews, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114171- (2024)
Summary: Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed adul
Externí odkaz:
https://doaj.org/article/a0c95ce71b2948fb906573474156e723
Autor:
Flavio Matassoli, Alberto Cagigi, Chen-Hsiang Shen, Amy R. Henry, Timothy S. Johnston, Chaim A. Schramm, Christopher A. Cottrell, Oleksandr Kalyuzhniy, Abby Spangler, Leigh Eller, Merlin Robb, Michael Eller, Prossy Naluyima, Peter D. Kwong, Daniel C. Douek, William R. Schief, Sarah F. Andrews, Adrian B. McDermott
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113450- (2023)
Summary: HIV gp120 engineered outer domain germline-targeting version 8 (eOD-GT8) was designed specifically to engage naive B cell precursors of VRC01-class antibodies. However, the frequency and affinity of naive B cell precursors able to recognize
Externí odkaz:
https://doaj.org/article/eb4e28b80f1b4f7e8299b3bde7fa669f
Autor:
Kristin L. Boswell, Timothy A. Watkins, Evan M. Cale, Jakob Samsel, Sarah F. Andrews, David R. Ambrozak, Jefferson I. Driscoll, Michael A. Messina, Sandeep Narpala, Christine S. Hopp, Alberto Cagigi, Joseph P. Casazza, Takuya Yamamoto, Tongqing Zhou, William R. Schief, Peter D. Crompton, Julie E. Ledgerwood, Mark Connors, Lucio Gama, Peter D. Kwong, Adrian McDermott, John R. Mascola, Richard A. Koup
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The isolation and characterization of neutralizing antibodies from infection and vaccine settings informs future vaccine design, and methodologies that streamline the isolation of antibodies and the generation of B cell clones are of great interest.
Externí odkaz:
https://doaj.org/article/5545d1b2bd774ffa82a9c22a398ffe25
Autor:
Adrian Creanga, Rebecca A. Gillespie, Brian E. Fisher, Sarah F. Andrews, Julia Lederhofer, Christina Yap, Liam Hatch, Tyler Stephens, Yaroslav Tsybovsky, Michelle C. Crank, Julie E. Ledgerwood, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the human antibody response to influenza A virus strains is important for vaccine development. Here, Creanga et al. generate a panel of 55 replication-deficient reporter viruses representing diversity of human H1N1 and H3N2, and pandemi
Externí odkaz:
https://doaj.org/article/f356614b040e47ff842a80b70937a8bb
Autor:
Seyhan Boyoglu-Barnum, Geoffrey B. Hutchinson, Jeffrey C. Boyington, Syed M. Moin, Rebecca A. Gillespie, Yaroslav Tsybovsky, Tyler Stephens, John R. Vaile, Julia Lederhofer, Kizzmekia S. Corbett, Brian E. Fisher, Hadi M. Yassine, Sarah F. Andrews, Michelle C. Crank, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Masaru Kanekiyo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Influenza virus hemagglutinin (HA) stem between group 1 and 2 viruses has different glycosylation patterns, likely hampering cross-group protection. Here, Boyoglu-Barnum et al. show that introducing a group 2 glycan into a group 1 stem nanoparticle v
Externí odkaz:
https://doaj.org/article/341c5ca3cd954a0f92613862f3db746e
Autor:
Kizzmekia S. Corbett, Syed M. Moin, Hadi M. Yassine, Alberto Cagigi, Masaru Kanekiyo, Seyhan Boyoglu-Barnum, Sky I. Myers, Yaroslav Tsybovsky, Adam K. Wheatley, Chaim A. Schramm, Rebecca A. Gillespie, Wei Shi, Lingshu Wang, Yi Zhang, Sarah F. Andrews, M. Gordon Joyce, Michelle C. Crank, Daniel C. Douek, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Jeffrey C. Boyington
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. While HA stem-based
Externí odkaz:
https://doaj.org/article/cd997d727dab4f9a9bff7e2660bf416f
Publikováno v:
Nature Computational Science. 3:164-173
Antibodies constitute a key line of defense against the diverse pathogens we encounter in our lives. Although the interactions between a single antibody and a single virus are routinely characterized in exquisite detail, the inherent tradeoffs betwee
Autor:
Sarah F. Andrews, Lauren Y. Cominsky, Geoffrey D. Shimberg, Rebecca A. Gillespie, Jason Gorman, Julie E. Raab, Joshua Brand, Adrian Creanga, Suprabhath R. Gajjala, Sandeep Narpala, Crystal S. F. Cheung, Darcy R. Harris, Tongqing Zhou, Ingelise Gordon, LaSonji Holman, Floreliz Mendoza, Katherine V. Houser, Grace L. Chen, John R. Mascola, Barney S. Graham, Peter D. Kwong, Alicia Widge, Lesia K. Dropulic, Julie E. Ledgerwood, Masaru Kanekiyo, Adrian B. McDermott
Publikováno v:
Science Translational Medicine. 15
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses provide protection against the vaccinating stra
Autor:
John R. Mascola, Sarah F. Andrews, Barney S. Graham, Tyler Stephens, Julia Lederhofer, Brian E. Fisher, Christina Yap, Yaroslav Tsybovsky, Adrian B. McDermott, Liam Hatch, Rebecca A. Gillespie, Adrian Creanga, Julie E. Ledgerwood, Masaru Kanekiyo, Michelle C. Crank
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Broadly neutralizing antibodies (bnAbs) have been developed as potential countermeasures for seasonal and pandemic influenza. Deep characterization of these bnAbs and polyclonal sera provides pivotal understanding for influenza immunity and informs e