Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sarah Eckenrode"'
Autor:
Leena Peltonen, Yan Zhang, Bing Yi, Weipeng Zheng, Qing-Guo Ruan, Jin-Xiong She, Sharad Purohit, Sarah Eckenrode, Daniel Eisenman, Kenneth S. K. Tung, Yulius Setiady
Publikováno v:
The Journal of Immunology. 178:7173-7180
The autoimmune regulator (Aire) gene plays an essential role in negative selection of T cells and deletion of autoreactive T cells in the thymus. The defect in thymic selection in Aire−/− mice was attributed to the repressed expression of tissue-
Autor:
Yan Zhang, Yongsoo Park, Zheng Dong, Chaim O. Jacob, Robert H. Podolsky, Ping Yang, Weipeng Zheng, Jean Francois Bach, Mark A. Atkinson, Sarah Eckenrode, Dehuang Guo, Todd M. Brusko, Jinzhao Wang, Diane Hopkins, Manuel Serrano-Ríos, María Teresa Martínez Larrad, Leslie J. Raffel, Adina Zeidler, Manyu Li, Sharad Purohit, Cong-Yi Wang, Jin-Xiong She, Zixin Zhang, Jerome I. Rotter, Henri Jean Garchon, Andrew Muir, Paolo Pozzilli
Publikováno v:
Nature Genetics. 36:837-841
Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been challenging and largely limited to known candidate genes. Here, we report e
Publikováno v:
Diabetes. 53:366-375
cDNA microarrays with >11,000 cDNA clones from an NOD spleen cDNA library were used to identify temporal gene expression changes in NOD mice (1–10 weeks), which spontaneously develop type 1 diabetes, and changes between NOD and NOD congenic mice (N
Autor:
Kim Ahrens, Li-Jun Yang, Hongshan Zhao, Qing Guo Ruan, Sarah Eckenrode, Christine Collins, Jin-Xiong She, Richard A. McIndoe, Shiwu Li
Publikováno v:
The Journal of Molecular Diagnostics. 5:212-221
Using cDNA microarrays we determined the gene expression patterns in the human acute promyelocytic leukemia (APL) cell line NB4 during all-trans retinoic acid (ATRA)-induced differentiation. We analyzed the expression of 12,288 genes in the NB4 cells
Autor:
Ping Yang, Sarah Eckenrode, Karen H.S. Wilson, Richard A. McIndoe, Jin-Xiong She, Qing Guo Ruan, Abdoreza Davoodi-Semiromi, Quan Zhen Li, Byron P. Croker, Jing Da Shi
Publikováno v:
Diabetes. 52:2151-2159
We profiled the expression of 5,760 clones from a kidney subtraction library in the kidneys of three groups of NOD mice: nondiabetic, new-onset, and long-term diabetic. A total of 27 genes had lower expression and 1 gene (Gpx3) had higher expression
Autor:
David R. Nelson, Christin D. Collins, Richard A. McIndoe, James M. Crawford, Jin-Xiong She, Chen Liu, Hongshan Zhao, Qingguo Run, Sarah Eckenrode, Haizhen Zhu
Publikováno v:
Hepatology. 37:1180-1188
Interferon alfa (IFN-α)-based treatment is the only therapeutic option for chronic hepatitis C viral infection. However, the molecular mechanisms of IFN-α antiviral activity are not completely understood. The recent development of an HCV replicon c
Autor:
Quan-Zhen Li, Sarah Eckenrode, Qing-Guo Ruan, Cong-Yi Wang, Jing-Da Shi, Richard A. McIndoe, Jin-Xiong She
Publikováno v:
Mammalian Genome. :0830-0836
Autor:
James J. Yang, Sarah Eckenrode, Richard A. McIndoe, Samuel S. Wu, Jin-Xiong She, Mark C. K. Yang, Qing-Guo Ruan
Publikováno v:
Physiological Genomics. 7:45-53
Over the last few years, there has been a dramatic increase in the use of cDNA microarrays to monitor gene expression changes in biological systems. Data from these experiments are usually transformed into expression ratios between experimental sampl
Autor:
Quan Zhen Li, Cong-Yi Wang, Wei Lian, Donghai Wu, Qing Guo Ruan, Sarah Eckenrode, Jin Da Shi, Thomas Kukar, Yunrong Gu, Jin-Xiong She, Abdoreza Davoodi-Semiromi
Publikováno v:
Gene. 273:275-284
We report here the cloning and characterization of a novel gene belonging to the tubby superfamily proteins (TUSP) in mouse and human. The mouse Tusp cDNA is 9120 bp in length and encodes a deduced protein of 1547 amino acids, while the human TUSP ge
Autor:
Adina Zeidler, Jin-Xiong She, Mark C. K. Yang, Jean Francois Bach, James J. Yang, Sarah Eckenrode, Diane Hopkins, Michele P. Marron, Yongsoo Park, Henri Jean Garchon, Chaim O. Jacob, Leslie J. Raffel, Jerome I. Rotter, Manuel Serrano-Ríos, María Teresa Martínez Larrad
Publikováno v:
Diabetes. 49:492-499
Polymorphic markers within the CTLA4 gene on chromosome 2q33 have been shown to be associated with type 1 diabetes. Therefore, a gene responsible for the disease (IDDM12) most likely lies within a region of