Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sarah E. Woodfield"'
Autor:
Mercedes Barzi, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, Yunhan Ma, Sabrina Collias, Sarah E. Woodfield, Anna Mae Diehl, Sanjeev A. Vasudevan, Thao N. Galvan, John Goss, Charles A. Gersbach, Beatrice Bissig-Choisat, Aravind Asokan, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver chimeric transgene-free Il2rg −/
Externí odkaz:
https://doaj.org/article/3464bdb424c442108002dbd891da2d8d
Autor:
Andres F. Espinoza, Kalyani R. Patel, Priya B. Shetty, Richard S. Whitlock, Pavel Sumazin, Xinjian Yu, Stephen F. Sarabia, Martin Urbicain, Andras Heczey, Prakash Masand, Sarah E. Woodfield, Dolores H. López‐Terrada, Sanjeev A. Vasudevan
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21270-21278 (2023)
Abstract Objective Hepatoblastoma (HB) is the most common primary hepatic malignancy in childhood. Relapse occurs in more than 50% of high‐risk patients with a high mortality due to ineffective salvage therapies. The purpose of this study is to ide
Externí odkaz:
https://doaj.org/article/0c97209ea30843db8d7cf1592b8908cd
Autor:
Smadar Kahana-Edwin, James Torpy, Lucy E. Cain, Anna Mullins, Geoffrey McCowage, Sarah E. Woodfield, Sanjeev A. Vasudevan, Dan P. T. Shea, Andre E. Minoche, Andres F. Espinoza, Sarah Kummerfeld, Leonard D. Goldstein, Jonathan Karpelowsky
Publikováno v:
Cancers, Vol 16, Iss 1, p 12 (2023)
Hepatoblastoma is characterized by driver mutations in CTNNB1, making it an attractive biomarker for a liquid biopsy approach utilizing circulating tumor DNA (ctDNA). This prospective observational study sought to ascertain the feasibility of ctDNA d
Externí odkaz:
https://doaj.org/article/480ac4a3d44c4ea48fb151f8fbf6958d
Autor:
Sarah E. Woodfield, Brandon J. Mistretta, Roma H. Patel, Aryana M. Ibarra, Kevin E. Fisher, Stephen F. Sarabia, Ilavarasi Gandhi, Jacquelyn Reuther, Zbigniew Starosolski, Andrew Badachhape, Jessica Epps, Barry Zorman, Aayushi P. Shah, Samuel R. Larson, Rohit K. Srivastava, Yan Shi, Andres F. Espinoza, Saiabhiroop R. Govindu, Richard S. Whitlock, Kimberly Holloway, Angshumoy Roy, Pavel Sumazin, Ketan B. Ghaghada, Dolores Lopez-Terrada, Preethi H. Gunaratne, Sanjeev A. Vasudevan
Publikováno v:
Biology Open, Vol 11, Iss 9 (2022)
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models t
Externí odkaz:
https://doaj.org/article/19d25bfd932e459dbc19467d36d3ca80
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to improve outcomes and patient qu
Externí odkaz:
https://doaj.org/article/2c835b5e701047a99457ad48818f16a6
Author Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Rohit K. Srivastava, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/4d0f9217fca3401482d0f49ebd128ace
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Jingling Jin, Angela Major, Stephen F. Sarabia, Zbigniew Starosolski, Barry Zorman, Siddharth S. Gupta, Zhenghu Chen, Aryana M. Ibarra, Karl-Dimiter Bissig, Ketan B. Ghaghada, Pavel Sumazin, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines in
Externí odkaz:
https://doaj.org/article/6656677b34c24573aea30e99a87fadd7
Publikováno v:
Cancers, Vol 12, Iss 2, p 273 (2020)
Hepatoblastoma (HB) is the most common pediatric liver malignancy. Management of HB requires multidisciplinary efforts. The 5-year overall survival of this disease is about 80% in developed countries. Despite advances in the care of these patients, s
Externí odkaz:
https://doaj.org/article/e0992d700f4a405894328dbb12e67ad8
Autor:
Jed G. Nuchtern, Jianhua Yang, Sanjeev A. Vasudevan, Sarah E. Woodfield, Kevin Guo, Jiaxiong Lu, Hui Li, Zhenghu Chen, Yihui Fan, Yanling Zhao, Yang Yu
Neuroblastoma is the most common extracranial malignant solid tumor in children, and drug resistance is a major reason for poor outcomes. Elevated proteasome activity plays an important role in neuroblastoma tumor development and resistance to conven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa8bafb0626394e568e3b5c2186480
https://doi.org/10.1158/1535-7163.c.6538332.v1
https://doi.org/10.1158/1535-7163.c.6538332.v1
Autor:
Jed G. Nuchtern, Jianhua Yang, Sanjeev A. Vasudevan, Sarah E. Woodfield, Kevin Guo, Jiaxiong Lu, Hui Li, Zhenghu Chen, Yihui Fan, Yanling Zhao, Yang Yu
USP14 inhibitor b-AP15 inhibits colony formation in neuroblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af0c32d24e2a13c35eccba34887a4db
https://doi.org/10.1158/1535-7163.22506228.v1
https://doi.org/10.1158/1535-7163.22506228.v1