Výsledky vyhledávání - "Sarah E. Strassler"

In vivo characterization of the critical interaction between the RNA exosome and the essential RNA helicase Mtr4 inSaccharomyces cerevisiae

Autor: Maria C Sterrett, Daniela Farchi, Sarah E Strassler, Lawrence H Boise, Milo B Fasken, Anita H Corbett

Publikováno v: G3 Genes|Genomes|Genetics.

The RNA exosome is a conserved molecular machine that processes/degrades numerous coding and non-coding RNAs. The 10-subunit complex is composed of three S1/KH cap subunits (human EXOSC2/3/1; yeast Rrp4/40/Csl4), a lower ring of six PH-like subunits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61742397218e41e5c3eb40466d460b9e
https://doi.org/10.1093/g3journal/jkad049

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tRNA m (1) G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

Autor: Sarah E. Strassler, Isobel E. Bowles, Aiswarya Krishnamohan, Hyejeong Kim, Emily G. Kuiper, Lindsay R. Comstock, Jane E. Jackman, Graeme L. Conn

Publikováno v: bioRxiv

The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77869d49271800f1881f022c07e6fa6
https://europepmc.org/articles/PMC9915607/

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In vivoCharacterization of the Critical Interaction between the RNA Exosome and the Essential RNA Helicase Mtr4 inSaccharomyces cerevisiae

Autor: Maria C. Sterrett, Daniela Farchi, Sarah E. Strassler, Lawrence H. Boise, Milo B. Fasken, Anita H. Corbett

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::249c5be31d88688ff5c17567619962b1
https://doi.org/10.1101/2022.10.31.514520

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A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex

Autor: Sara W. Leung, Richard Baker, Richard S. Lee, Sarah E. Strassler, Munira A. Basrai, Liz Enyenihi, Laurie Hess, Elise S. Withers, Isaac Kremsky, Maria C. Sterrett, Anita H. Corbett, Milo B. Fasken, Daniela Farchi, Ambro van Hoof

Publikováno v: RNA. 27:1046-1067

RNA exosomopathies, a growing family of diseases, are linked to missense mutations in genes encoding structural subunits of the evolutionarily conserved, 10-subunit exoribonuclease complex, the RNA exosome. This complex consists of a three-subunit ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9676bd9b83a84f217103e157cc78e7c
https://doi.org/10.1261/rna.078618.120

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Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases

Autor: Sarah E, Strassler, Isobel E, Bowles, Debayan, Dey, Jane E, Jackman, Graeme L, Conn

Publikováno v: Journal of Biological Chemistry. 298:102393

The SpoU-TrmD (SPOUT) methyltransferase superfamily was designated when structural similarity was identified between the transfer RNA-modifying enzymes TrmH (SpoU) and TrmD. SPOUT methyltransferases are found in all domains of life and predominantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3c89ca7ad5fad04dca469003ba268f
https://doi.org/10.1016/j.jbc.2022.102393

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A budding yeast model for human disease mutations in the

Autor: Maria C, Sterrett, Liz, Enyenihi, Sara W, Leung, Laurie, Hess, Sarah E, Strassler, Daniela, Farchi, Richard S, Lee, Elise S, Withers, Isaac, Kremsky, Richard E, Baker, Munira A, Basrai, Ambro, van Hoof, Milo B, Fasken, Anita H, Corbett

Publikováno v: RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5d64bfa72e5212a1b375190661795c4
https://pubmed.ncbi.nlm.nih.gov/34162742

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A Budding Yeast Model for Human Disease Mutations in the EXOSC2 Cap Subunit of the RNA Exosome

Autor: Maria C. Sterrett, Liz Enyenihi, Sara W. Leung, Laurie Hess, Sarah E. Strassler, Daniela Farchi, Richard S. Lee, Elise S. Withers, Isaac Kremsky, Richard E. Baker, Munira A. Basrai, Ambro van Hoof, Milo B. Fasken, Anita H. Corbett

RNA exosomopathies, a growing family of tissue-specific diseases, are linked to missense mutations in genes encoding the structural subunits of the conserved 10-subunit exoribonuclease complex, the RNA exosome. Such mutations in the cap subunit gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbff2b129e62f025530ef4f7c2747a73
https://doi.org/10.1101/2020.12.06.413658

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Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition

Autor: Atousa Mehrani, Sarah E. Strassler, Debayan Dey, Scott M. Stagg, Natalia Zelinskaya, Christine M. Dunham, Eric D. Hoffer, Graeme L. Conn, Meisam Nosrati

Publikováno v: J Biol Chem

Methylation of the small ribosome subunit rRNA in the ribosomal decoding center results in exceptionally high-level aminoglycoside resistance in bacteria. Enzymes that methylate 16S rRNA on N7 of nucleotide G1405 (m7G1405) have been identified in bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f800a1408054ade5a8f12cebccc936a

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