Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sarah E. Shelton"'
Autor:
Giovanni S. Offeddu, Elena Cambria, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, Roger D. Kamm
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high disease mortality. Personalized in vitro bre
Externí odkaz:
https://doaj.org/article/a394968a50cf4ecb907cb7897f5472c7
Autor:
Zhengpeng Wan, Shun Zhang, Amy X. Zhong, Liling Xu, Mark F. Coughlin, Georgios Pavlou, Sarah E. Shelton, Huu Tuan Nguyen, Satomi Hirose, Seunggyu Kim, Marie A. Floryan, David A. Barbie, F. Stephen Hodi, Roger D. Kamm
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Endothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than in normal tissues. Also, tumoral vasculatures tend to be leakier than normal vessels leading to a higher trans‐endothelial or transmural fluid flow. Howe
Externí odkaz:
https://doaj.org/article/e0b6d2b3cd9a4d6185b943c5ce795bda
Autor:
Dae Joong Kim, Swetha Anandh, Jamie L. Null, Piotr Przanowski, Sanchita Bhatnagar, Pankaj Kumar, Sarah E. Shelton, Erin E. Grundy, Katherine B. Chiappinelli, Roger D. Kamm, David A. Barbie, Andrew C. Dudley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Targeting DNA methyltransferase 1 (DNMT1) has immunomodulatory and anti-neoplastic activity, especially when paired with cancer immunotherapies. Here we explore the immunoregulatory functions of DNMT1 in the tumor vasculature of female mice.
Externí odkaz:
https://doaj.org/article/5ba899d284fd457f8d38e9095d8fd28e
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101985- (2021)
Summary: This review describes recent research that has advanced our understanding of the role of immune cells in the tumor microenvironment (TME) using advanced 3D in vitro models and engineering approaches. The TME can hinder effective eradication
Externí odkaz:
https://doaj.org/article/71c58e95598b4a84a7ea49bab20885c7
Autor:
Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is
Externí odkaz:
https://doaj.org/article/348d85a40f0943e896d94e5eb485e66c
Publikováno v:
International Journal of Biomedical Imaging, Vol 2020 (2020)
The purpose of this study is to determine if microvascular tortuosity can be used as an imaging biomarker for the presence of tumor-associated angiogenesis and if imaging this biomarker can be used as a specific and sensitive method of locating solid
Externí odkaz:
https://doaj.org/article/5ef0ba4e27154c1b85968fef3f9fa697
Autor:
Emmanouil Angelidakis, Sophia Chen, Shun Zhang, Zhengpeng Wan, Roger D. Kamm, Sarah E. Shelton
A bidirectional association exists between metastatic dissemination and the hypercoagulable state associated with many types of cancer. As such, clinical studies have provided evidence that markers associated with elevated levels of coagulation and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4e9ecc161a675001d1c0ad9149058b
https://zenodo.org/record/7941894
https://zenodo.org/record/7941894
Autor:
Zhengpeng Wan, Marie A. Floryan, Mark F. Coughlin, Shun Zhang, Amy X. Zhong, Sarah E. Shelton, Xun Wang, Chenguang Xu, David A. Barbie, Roger D. Kamm
Publikováno v:
Advanced healthcare materials.
Previous studies have developed vascularized tumor spheroid models to demonstrate the impact of intravascular flow on tumor progression and treatment. However, these models have not been widely adopted so the vascularization of tumor spheroids in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b59ccf4362b65b271151bab54acb17
https://pubmed.ncbi.nlm.nih.gov/36333913
https://pubmed.ncbi.nlm.nih.gov/36333913
Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies
Autor:
Marco Campisi, Sarah E. Shelton, Minyue Chen, Roger D. Kamm, David A. Barbie, Erik H. Knelson
Publikováno v:
Cancers. 14(15)
Cell therapies, including adoptive immune cell therapies and genetically engineered chimeric antigen receptor (CAR) T or NK cells, have shown promise in treating hematologic malignancies. Yet, immune cell infiltration and expansion has proven challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b2f978b4cb8ad63ecaba7fbb9f570
https://pubmed.ncbi.nlm.nih.gov/35892819
https://pubmed.ncbi.nlm.nih.gov/35892819
Autor:
Zhengpeng Wan, Amy X. Zhong, Shun Zhang, Georgios Pavlou, Mark F. Coughlin, Sarah E. Shelton, Huu Tuan Nguyen, Jochen H. Lorch, David A. Barbie, Roger D. Kamm
Publikováno v:
Small methods. 6(6)
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6b66e4c4a5e4018e67ff3a05d68802
https://pubmed.ncbi.nlm.nih.gov/35373502
https://pubmed.ncbi.nlm.nih.gov/35373502