Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarah E. Seiler"'
Autor:
Sarah E. Seiler, Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, Deborah M. Muoio
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 635-644 (2014)
Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance an
Externí odkaz:
https://doaj.org/article/4ee4bb6ffe9b483faa5be0ed9c3553fb
Autor:
Dan Xu, Jean-Paul Kovalik, Sarah E Seiler, Jia Pei Ho, Lei Sun, Benjamin M. Buehrer, Kinyui Alice Lo, Y John W Ludlow
Publikováno v:
Adipocyte. 4:303-310
Brown fat has gained widespread attention as a potential therapeutic target to treat obesity and associated metabolic disorders. Indeed, the anti-obesity potential of multiple targets to stimulate both brown adipocyte differentiation and recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138767581a01a8ea460ee0690207f93a
https://doi.org/10.1080/21623945.2015.1042192
https://doi.org/10.1080/21623945.2015.1042192
Autor:
Karen L. DeBalsi, Karen I. Crain, Olga Ilkayeva, Michael Kinter, Robert Stevens, Sarah E. Seiler, Dorothy H. Slentz, C. Lawrence Kien, Catherine R. Mikus, Kari E. Wong, Deborah M. Muoio
Publikováno v:
Diabetes
This study used mice with muscle-specific overexpression of PGC-1α, a transcriptional coactivator that promotes mitochondrial biogenesis, to determine whether increased oxidative potential facilitates metabolic improvements in response to lifestyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ceb101519ca31a28acdd818de8ac43
http://europepmc.org/articles/PMC4407850
http://europepmc.org/articles/PMC4407850
Autor:
Deborah M. Muoio, Karen L. DeBalsi, Timothy R. Koves, Dorothy H. Slentz, Robert C. Noland, Ola J. Martin, Olga Ilkayeva, Sarah E. Seiler, Jie An, Christopher B. Newgard
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 635-644 (2014)
Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfc7ccd7b26bc8d05fe34d5489ca8bc
http://www.sciencedirect.com/science/article/pii/S0022227520376537
http://www.sciencedirect.com/science/article/pii/S0022227520376537
Autor:
Simon T. Hui, Karen L. DeBalsi, Sarah E. Seiler, Christopher G. R. Perry, Timothy R. Koves, P. Darrell Neufer, Olga Ilkayeva, Kari E. Wong, Robert Stevens, Luke I. Szweda, Deborah M. Muoio, Dorothy H. Slentz, Daniel S. Lark, April H. Wittmann
Publikováno v:
Journal of Biological Chemistry. 289:8106-8120
Thioredoxin-interacting protein (TXNIP) is an α-arrestin family member involved in redox sensing and metabolic control. Growing evidence links TXNIP to mitochondrial function, but the molecular nature of this relationship has remained poorly defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7958c8c01c2d0880748df7fe72d11ea6
https://doi.org/10.1074/jbc.m113.511535
https://doi.org/10.1074/jbc.m113.511535
Autor:
Robert C. Noland, Jean Paul Kovalik, Michael N. Davies, Robert Stevens, Randall L. Mynatt, Karen L. DeBalsi, Deborah M. Muoio, Indu Kheterpal, Jeffrey D. Covington, Jingying Zhang, William E. Kraus, Eric Ravussin, Timothy R. Koves, Sarah E. Seiler, Olga Ilkayeva, Sudip Bajpeyi
Publikováno v:
Cell Metabolism. 15:764-777
SummaryThe concept of “metabolic inflexibility” was first introduced to describe the failure of insulin-resistant human subjects to appropriately adjust mitochondrial fuel selection in response to nutritional cues. This phenomenon has since gaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe1a83b79abf826d5d946351236e445
https://doi.org/10.1016/j.cmet.2012.04.005
https://doi.org/10.1016/j.cmet.2012.04.005
Autor:
Timothy R. Koves, Robert M. Lust, Olga Ilkayeva, Sarah E. Seiler, Deborah M. Muoio, Robert C. Noland, Helen Lum, Robert Stevens, Fausto G. Hegardt
Publikováno v:
Journal of Biological Chemistry. 284:22840-22852
In addition to its essential role in permitting mitochondrial import and oxidation of long chain fatty acids, carnitine also functions as an acyl group acceptor that facilitates mitochondrial export of excess carbons in the form of acylcarnitines. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43769b289d9efe12b820ef3986bec6c6
https://doi.org/10.1074/jbc.m109.032888
https://doi.org/10.1074/jbc.m109.032888
Autor:
Patrick Schrauwen, Karen L. DeBalsi, Kari E. Wong, Olga Ilkayeva, Lucas Lindeboom, April H. Wittmann, Deborah M. Muoio, Jessica R. Gooding, Robert Stevens, Sarah E. Seiler, Michael N. Davies, Vera B. Schrauwen-Hinderling, Timothy R. Koves
Publikováno v:
Cell Metabolism, 22(1), 65-76. Cell Press
SummaryAcylcarnitine metabolites have gained attention as biomarkers of nutrient stress, but their physiological relevance and metabolic purpose remain poorly understood. Short-chain carnitine conjugates, including acetylcarnitine, derive from their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d3faadcd60a7aca56268e9765e1728
https://europepmc.org/articles/PMC4754082/
https://europepmc.org/articles/PMC4754082/
