Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sarah E. S. Leary"'
Autor:
Brittany L. Greene, Shannon M. Stasi, Michelle A. Ting, Natalie Waligorski, Bonnie L. Cole, Christina M. Lockwood, Vera A. Paulson, Jillian G. Buchan, Amy Lee, Jeffrey G. Ojemann, Richard G. Ellenbogen, Jeffrey Stevens, Sarah E. S. Leary
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
PurposeSomatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous system neoplasms. Here, we report follow-up targeted germline evaluation for patients
Externí odkaz:
https://doaj.org/article/8310c51029a946e99c35aa8a93b40535
Autor:
Bingcheng Jiang, Cameron Murray, Bonnie L. Cole, J. N. Mark Glover, Gordon K. Chan, Jean Deschenes, Rajam S. Mani, Sudip Subedi, John D. Nerva, Anthony C. Wang, Christina M. Lockwood, Heather C. Mefford, Sarah E. S. Leary, Jeffery G. Ojemann, Michael Weinfeld, Chibawanye I. Ene
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3′-phosphatase and DNA 5′-kinase activities, which are required for processing termini of single- and double-strand breaks generated by reactive ox
Externí odkaz:
https://doaj.org/article/691b06de37ce47d1a593a40ce1fec6f7
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 7, p 219 (2022)
Background: Pediatric brain tumors are the leading cause of cancer death in children and represent a variety of diseases and molecular subtypes. This study sought to evaluate a rapid immunohistochemistry testing panel to aid in therapy selection at t
Externí odkaz:
https://doaj.org/article/b890abde404e40aabc4449c505a06aaa
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Genetic data are rapidly becoming part of tumor classification and are integral to prognosis and predicting response to therapy. Current molecular tumor profiling relies heavily on tissue resection or biopsy. Tissue profiling has several disadvantage
Externí odkaz:
https://doaj.org/article/ad5b8864be614db787cdbb559f68af3d
Autor:
Vera A. Paulson, Yajuan J. Liu, He Fang, Sam R. Browd, Jason S. Hauptman, Jason Wright, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole
Publikováno v:
JCO Precision Oncology.
Autor:
Margot A Lazow, Mariko DeWire, Olivia Campagne, James L Leach, Christine Fuller, Shiva Senthil Kumar, Joseph Stanek, Peter de Blank, Trent R Hummel, Natasha Pillay-Smiley, Ralph Salloum, Charles B Stevenson, Patricia Baxter, David Gass, Stewart Goldman, Sarah E S Leary, Adam Carle, Adam Lane, Rachid Drissi, Clinton Stewart, Maryam Fouladi
Publikováno v:
Neuro-Oncology. 24:i36-i37
BACKGROUND: Dual inhibition of CDK4/6 and mTOR in DIPG and pediatric HGG has strong biologic rationale, given prevalent genetic alterations resulting in upregulated cell cycle and PI3K/mTOR pathways in these diseases, as well as non-overlapping agent
Autor:
Mariko DeWire, Margot Lazow, Olivia Campagne, James Leach, Christine Fuller, Shiva Senthil Kumar, Joseph Stanek, Peter de Blank, Trent R Hummel, Natasha Pillay-Smiley, Ralph Salloum, Charles B Stevenson, Patricia Baxter, David Gass, Stewart Goldman, Sarah E S Leary, Adam Carle, Leonie Mikael, Dorothy Crabtree, Brooklyn Chaney, Adam Lane, Rachid Drissi, Clinton F Stewart, Maryam Fouladi
Publikováno v:
Neuro-Oncology Advances. 4
Background Genomic aberrations in the cell cycle and PI3K/Akt/mTOR pathways have been reported in diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG). Dual inhibition of CDK4/6 and mTOR has biologic rationale and minimal overlapping t
Autor:
Kathryn P. Scherpelz, Erin E. Crotty, Vera A. Paulson, Christina M. Lockwood, Sarah E. S. Leary, Richard G. Ellenbogen, Amy Lee, Ralph P. Ermoian, Nicholas A. Vitanza, Bonnie L. Cole
Publikováno v:
Pediatric bloodcancerREFERENCES. 69(4)
Pineal anlage tumor is a rare pediatric tumor with clinical and histological features overlapping with pineoblastoma. Two patients with pineal anlage tumor, a 13-month-old female and an 11-month-old male, underwent subtotal resection, high-dose chemo
Publikováno v:
Frontiers in bioscience (Landmark edition). 27(7)
Pediatric brain tumors are the leading cause of cancer death in children and represent a variety of diseases and molecular subtypes. This study sought to evaluate a rapid immunohistochemistry testing panel to aid in therapy selection at the time of m
Autor:
Margot A Lazow, Patricia Baxter, Joseph Stanek, Adam Lane, Diana P Rodriguez, Shiva Senthil Kumar, James L Leach, Leonie Mikael, Christine Fuller, Daniel R Boué, Christopher R Pierson, Diana Thomas, John Breneman, Joshua Palmer, Xiao-Nan Li, Ralph Salloum, David Ashley, Peter de Blank, Eugene Hwang, Sarah E S Leary, Ashley Plant, Dorothy Crabtree, Mona Wahba, Marla Weetall, John Baird, Jeffrey Leonard, Clinton F Stewart, Elaine Mardis, Maryam Fouladi, Rachid Drissi
Publikováno v:
Neuro-Oncology. 24:i36-i36
BACKGROUND: The B-cell-specific Moloney murine leukemia virus integration site-1 (BMI-1) protein, implicated in self-renewal and DNA-damage signaling, is highly expressed in DIPG and HGG. Preclinically, BMI-1 modulation by unesbulin (PTC596 [which me