Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Sarah E. M. Herman"'
Autor:
Dan A. Landau, Clare Sun, Daniel Rosebrock, Sarah E. M. Herman, Joshua Fein, Mariela Sivina, Chingiz Underbayev, Delong Liu, Julia Hoellenriegel, Sarangan Ravichandran, Mohammed Z. H. Farooqui, Wandi Zhang, Carrie Cibulskis, Asaf Zviran, Donna S. Neuberg, Dimitri Livitz, Ivana Bozic, Ignaty Leshchiner, Gad Getz, Jan A. Burger, Adrian Wiestner, Catherine J. Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
In a subset of patients with chronic lymphocytic leukemia (CLL) treated with targeted agents, such as ibrutinib, drug resistant subclones emerge. Here, the authors report on transcriptional changes in CLL patients treated with ibrutinib and identify
Externí odkaz:
https://doaj.org/article/8cb0dbf9095d4ad38df29729f10e5da6
Autor:
Andrew H. Lipsky, Mohammed Z.H. Farooqui, Xin Tian, Sabrina Martyr, Ann M. Cullinane, Khanh Nghiem, Clare Sun, Janet Valdez, Carsten U. Niemann, Sarah E. M. Herman, Nakhle Saba, Susan Soto, Gerald Marti, Gulbu Uzel, Steve M. Holland, Jay N. Lozier, Adrian Wiestner
Publikováno v:
Haematologica, Vol 100, Iss 12 (2015)
Ibrutinib is associated with bleeding-related adverse events of grade ≤2 in severity, and infrequently with grade ≥3 events. To investigate the mechanisms of bleeding and identify patients at risk, we prospectively assessed platelet function and
Externí odkaz:
https://doaj.org/article/d75d533e17b04f32bc69e6334efd688a
Autor:
Sarah E. M. Herman, Adrian Wiestner, Ari Melnick, Hana Safah, Chingiz Underbayev, Cydney M. Nichols, Erik K. Flemington, Lorena Fontan, Delong Liu, Eman L. Dadashian, Patricia Lobelle-Rich, Jessica R. Iyer, Georges Tanios, Deanna H. Wong, Nakhle S. Saba
Description and Legends for Supplementary Tables S1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7ca9fc31b0aadb73d9e2bfcc71cf44
https://doi.org/10.1158/0008-5472.22416350.v1
https://doi.org/10.1158/0008-5472.22416350.v1
Autor:
Sarah E. M. Herman, Adrian Wiestner, Ari Melnick, Hana Safah, Chingiz Underbayev, Cydney M. Nichols, Erik K. Flemington, Lorena Fontan, Delong Liu, Eman L. Dadashian, Patricia Lobelle-Rich, Jessica R. Iyer, Georges Tanios, Deanna H. Wong, Nakhle S. Saba
The clinical efficacy displayed by ibrutinib in chronic lymphocytic leukemia (CLL) has been challenged by the frequent emergence of resistant clones. The ibrutinib target, Bruton's tyrosine kinase (BTK), is essential for B-cell receptor signaling, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bf90727eb627a2e58fb54bc0fdd596
https://doi.org/10.1158/0008-5472.c.6509528
https://doi.org/10.1158/0008-5472.c.6509528
Autor:
Sarah E. M. Herman, Adrian Wiestner, Louis M. Staudt, Michael J. Kruhlak, Jessica R. Iyer, Ryan M. Young, Arthur L. Shaffer, Delong Liu, Erin M. McAuley, Eman L. Dadashian
Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells driven by B-cell receptor (BCR) signaling and activated primarily in the lymph node. The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib effectively inhibits BCR-dependent prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2bd0ebe4046bd3c06c613313c07d9
https://doi.org/10.1158/0008-5472.c.6510918.v1
https://doi.org/10.1158/0008-5472.c.6510918.v1
Autor:
Sarah E. M. Herman, Adrian Wiestner, Ari Melnick, Hana Safah, Chingiz Underbayev, Cydney M. Nichols, Erik K. Flemington, Lorena Fontan, Delong Liu, Eman L. Dadashian, Patricia Lobelle-Rich, Jessica R. Iyer, Georges Tanios, Deanna H. Wong, Nakhle S. Saba
Supp. Fig. S1: MI-2 causes a dose- and time-dependent apoptotic induction selectively in primary CLL cells with minimal toxicity to normal B cells. Supp. Fig. S2: Sensitivity to MI-2 is independent of clinical or biological features classically assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79994f4b9b0e9d1601e4b96e7f8ed3cf
https://doi.org/10.1158/0008-5472.22416353
https://doi.org/10.1158/0008-5472.22416353
Autor:
Sarah E. M. Herman, Adrian Wiestner, Louis M. Staudt, Michael J. Kruhlak, Jessica R. Iyer, Ryan M. Young, Arthur L. Shaffer, Delong Liu, Erin M. McAuley, Eman L. Dadashian
Supplementary Figure S1: Dose response experiments with the IRAK1/4 inhibitor (IRAKi) in CLL cells. Supplementary Figure S2: TLR signaling is active in lymph node-resident CLL cells. Supplementary Figure S3: Flow Cytometry gating strategy. Supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8497aed393eed621ee80443a6f84ec1c
https://doi.org/10.1158/0008-5472.22421409.v1
https://doi.org/10.1158/0008-5472.22421409.v1
Autor:
Sarah E. M. Herman, Adrian Wiestner, Ari Melnick, Hana Safah, Chingiz Underbayev, Cydney M. Nichols, Erik K. Flemington, Lorena Fontan, Delong Liu, Eman L. Dadashian, Patricia Lobelle-Rich, Jessica R. Iyer, Georges Tanios, Deanna H. Wong, Nakhle S. Saba
Supplementary Figure Legends S1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad3627d3fe1fa7559baeb4b07114421
https://doi.org/10.1158/0008-5472.22416359.v1
https://doi.org/10.1158/0008-5472.22416359.v1
Autor:
Sarah E. M. Herman, Adrian Wiestner, Ari Melnick, Hana Safah, Chingiz Underbayev, Cydney M. Nichols, Erik K. Flemington, Lorena Fontan, Delong Liu, Eman L. Dadashian, Patricia Lobelle-Rich, Jessica R. Iyer, Georges Tanios, Deanna H. Wong, Nakhle S. Saba
Supplementary Table S1. Patient characteristics. Supplementary Table S2. Characteristics of patients treated with ibrutinib. Supplementary Table S3. Primers and probes used for digital PCR. Supplementary Table S4. List of genes up- or down-regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa82218c44ae52bb5bf32f818401035
https://doi.org/10.1158/0008-5472.22416347
https://doi.org/10.1158/0008-5472.22416347
Autor:
Sarah E. M. Herman, Adrian Wiestner, Louis M. Staudt, Michael J. Kruhlak, Jessica R. Iyer, Ryan M. Young, Arthur L. Shaffer, Delong Liu, Erin M. McAuley, Eman L. Dadashian
Supplementary Figure Legends S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6226d651439e4da5fc04c7867a11a2
https://doi.org/10.1158/0008-5472.22421412
https://doi.org/10.1158/0008-5472.22421412