Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sarah E. Lacher"'
Autor:
Sarah E. Lacher, Tessa Schumann, Ryan Peters, Christopher Migliaccio, Andrij Holian, Matthew Slattery
Publikováno v:
Advances in Redox Research, Vol 13, Iss , Pp 100115- (2024)
Wildfire smoke is a potential source of oxidative stress in lung epithelial tissue. The response to oxidative stress is controlled by the transcription factor NRF2, which is the central regulator of antioxidant gene expression. If wood smoke particle
Externí odkaz:
https://doaj.org/article/3580802cc82b4321b07a98eb9572c232
Autor:
Sade Spencer, Catherine Burrows, Sarah E. Lacher, Kait C. Macheledt, Jerica M. Berge, Rahel G. Ghebre
Publikováno v:
Preventive Medicine Reports, Vol 24, Iss , Pp 101576- (2021)
Early-career female faculty, both physician scientists and basic researchers, have disproportionately experienced negative professional, financial, and personal consequences associated with the novel coronavirus disease 2019 (COVID-19) pandemic. This
Externí odkaz:
https://doaj.org/article/dcddcf2cf9f24e0db785e783e17d0e2e
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 401-411 (2018)
Reactive oxygen species (ROS), which are a byproduct of oxidative metabolism, serve as signaling molecules in a number of physiological settings. However, if their levels are not tightly maintained, excess ROS lead to potentially cytotoxic oxidative
Externí odkaz:
https://doaj.org/article/66145f0211b2449cb2f15931e676b3cb
Autor:
Sarah E. Lacher, Adnan Alazizi, Xuting Wang, Douglas A. Bell, Roger Pique-Regi, Francesca Luca, Matthew Slattery
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 686-693 (2018)
Late onset Alzheimer's disease (AD) is a multifactorial disorder, with AD risk influenced by both environmental and genetic factors. Recent genome-wide association studies (GWAS) have identified genetic loci associated with increased risk of developi
Externí odkaz:
https://doaj.org/article/583ce8dcb0654231b6c3e0b8cdd5db5e
Autor:
Xuting Wang, Michelle R. Campbell, Sarah E. Lacher, Hye-Youn Cho, Ma Wan, Christopher L. Crowl, Brian N. Chorley, Gareth L. Bond, Steven R. Kleeberger, Matthew Slattery, Douglas A. Bell
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 830-842 (2016)
The NRF2/sMAF protein complex regulates the oxidative stress response by occupying cis-acting enhancers containing an antioxidant response element (ARE). Integrating genome-wide maps of NRF2/sMAF occupancy with disease-susceptibility loci, we discove
Externí odkaz:
https://doaj.org/article/6732ec0f9ed54ef7b6c73c665f68a24d
Publikováno v:
Free Radical Biology and Medicine. 204:243-251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7915477c90eb95959c43cfa77340c82
https://doi.org/10.1016/j.freeradbiomed.2023.05.003
https://doi.org/10.1016/j.freeradbiomed.2023.05.003
Publikováno v:
Free Radic Biol Med
Reactive oxygen species (ROS) are important signaling molecules in many physiological processes, yet excess ROS leads to cell damage and can lead to pathology. Accordingly, cells need to maintain tight regulation of ROS levels, and ROS-responsive tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b094f482ff358246f3c46514b966ade0
https://pubmed.ncbi.nlm.nih.gov/33992677
https://pubmed.ncbi.nlm.nih.gov/33992677
Autor:
Rahel G Ghebre, Sade Spencer, Jerica M. Berge, Catherine A. Burrows, Kait C. Macheledt, Sarah E. Lacher
Publikováno v:
Preventive Medicine Reports
Preventive Medicine Reports, Vol 24, Iss, Pp 101576-(2021)
Preventive Medicine Reports, Vol 24, Iss, Pp 101576-(2021)
Early-career female faculty, both physician scientists and basic researchers, have disproportionately experienced negative professional, financial, and personal consequences associated with the novel coronavirus disease 2019 (COVID-19) pandemic. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ff44b0b1a3f39b7fb43009a746c8d1
https://pubmed.ncbi.nlm.nih.gov/34692377
https://pubmed.ncbi.nlm.nih.gov/34692377
Publikováno v:
Toxicology
The majority of single nucleotide variants (SNVs) identified in Genome Wide Association Studies (GWAS) fall within non-protein coding DNA and have the potential to alter gene expression. Non-protein coding DNA can control gene expression by acting as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0f8995b388031e9a9e09d27e2eadba
https://pubmed.ncbi.nlm.nih.gov/32450112
https://pubmed.ncbi.nlm.nih.gov/32450112
Autor:
Matthew Slattery, Sarah E. Lacher
Publikováno v:
Current opinion in toxicology
Reactive oxygen species (ROS), which are both a natural byproduct of oxidative metabolism and an undesirable byproduct of many environmental stressors, can damage all classes of cellular macromolecules and promote diseases from cancer to neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87406a5908060b8226bed1296c57ba5d
https://doi.org/10.1016/j.cotox.2016.09.001
https://doi.org/10.1016/j.cotox.2016.09.001