Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sarah E. Ferrara"'
Autor:
Eric T Clambey, Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Sana D Karam, Michael W Knitz, Ayman J Oweida, Adam C Mueller, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, Edward D Chan, Curtis R Pickering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the
Externí odkaz:
https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264
Autor:
Franklin W. Huang, Thomas R. Cech, Pablo Tamayo, William Kim, James C. Costello, Sarah E. Ferrara, Kevin Hu, Grace Hibshman, Josh Lewis Stern
Fig. S1. Projecting the individual TERTp mutations transcriptional signatures on top of the Onco-GPS map of cellular states (Kim et al. 2017). Fig.S2. Association between the different mRNA signatures analyzed in this study. Fig S3. Expression of epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a17e0ccd49fe3524bfc31a4c49c244f
https://doi.org/10.1158/1541-7786.22517913.v1
https://doi.org/10.1158/1541-7786.22517913.v1
Autor:
Franklin W. Huang, Thomas R. Cech, Pablo Tamayo, William Kim, James C. Costello, Sarah E. Ferrara, Kevin Hu, Grace Hibshman, Josh Lewis Stern
Table S1. TERTp mutations included in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f062ecdbddc9f127db3f36293abb6123
https://doi.org/10.1158/1541-7786.22517910
https://doi.org/10.1158/1541-7786.22517910
Autor:
Fumi Kinose, Anh T. Le, Adriana Estrada-Bernal, Robert C. Doebele, Minjae Yoo, Andrew Goodspeed, Sarah E. Ferrara, Andrea E. Doak, Aik Choon Tan, Uwe Rix, Laura Schubert
Publikováno v:
Molecular Pharmacology. 99:435-447
Rearranged during transfection (RET) rearrangements occur in 1% to 2% of lung adenocarcinomas as well as other malignancies and are now established targets for tyrosine kinase inhibitors. We developed three novel RET fusion-positive (RET+) patient-de
Autor:
Franklin W. Huang, Pablo Tamayo, Thomas R. Cech, Josh Lewis Stern, Sarah E. Ferrara, James C. Costello, Kevin Hu, Grace Hibshman, William Kim
Publikováno v:
Mol Cancer Res
Molecular cancer research : MCR, vol 18, iss 7
Molecular cancer research : MCR, vol 18, iss 7
In a substantial fraction of cancers TERT promoter (TERTp) mutations drive expression of the catalytic subunit of telomerase, contributing to their proliferative immortality. We conducted a pan-cancer analysis of cell lines and find a TERTp mutation
Autor:
Evelyn K. Bordeaux, Sarah E. Ferrara, Matthew J. Sikora, James C. Costello, Andrew Goodspeed, Joseph L. Sottnik, Sanjana Mehrotra
Publikováno v:
Mol Cancer Res
Invasive lobular carcinoma (ILC) is the most common special histologic subtype of breast cancer, and nearly all ILC tumors express estrogen receptor alpha (ER). However, clinical and laboratory data suggest ILC are strongly estrogen-driven but not eq
Autor:
Sanjana Mehrotra, Evelyn K. Bordeaux, Matthew J. Sikora, Joseph L. Sottnik, James C. Costello, Andrew Goodspeed, Sarah E. Ferrara
Invasive lobular carcinoma (ILC) is the most common histological subtype of breast cancer, and nearly all ILC tumors express estrogen receptor alpha (ER). However, clinical and laboratory data suggest ILC are strongly estrogen-driven but not equally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8de3b4314dff0edf3e05c5632e94899b
https://doi.org/10.1101/2020.12.16.423142
https://doi.org/10.1101/2020.12.16.423142
Autor:
Roberta Lugano, Yuki Fujiwara, Yuwen Zhu, Gefeng Zhu, Ronggui Lin, Lieping Chen, Linghua Zheng, Xiao Jing Wang, Carlton C. Barnett, Barish H. Edil, Sudarshan Anand, Yi Sun, Fan Gao, Robert J. Torphy, Anna Dimberg, Richard D. Schulick, Emily N. Miller, Wei Chen, Sheng Yao, Sarah E. Ferrara, Li Bian, Andrew Goodspeed, Weizhou Zhang
Publikováno v:
Sci Transl Med
Science translational medicine, vol 13, iss 604
Science translational medicine, vol 13, iss 604
The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that actively limits immune cell infiltration. The molecular basis underpinning this
Autor:
Sarah E. Ferrara, Joseph L. Sottnik, Evelyn K. Bordeaux, Matthew J. Sikora, Andrew Goodspeed, James C. Costello
Publikováno v:
Journal of the Endocrine Society
Invasive Lobular Carcinoma (ILC) is the 2nd most common histotype of breast cancer, but is critically understudied. ~95% of ILC are estrogen receptor (ER) positive, and previous studies demonstrate the importance of estrogen in ILC etiology. However,
Autor:
Edward Chan, Laurel B. Darragh, Adam C. Mueller, Xiyuan Bai, Douglas Grant Osborne, Curtis R. Pickering, Sana D. Karam, Mary-Keara Boss, Benjamin Van Court, Diemmy Nguyen, Jacob Gadwa, Shilpa Bhatia, Miles Piper, Shiv Bhuvane, Ayman Oweida, Varuna Nangia, Thomas E. Bickett, Sarah E. Ferrara, Matthew A. Burchill, Beth A. Jirón Tamburini, Michael W. Knitz, Andrew Goodspeed, Eric T. Clambey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundNumerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate ther