Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah E. David"'
Autor:
Jagdeep T, Podichetty, Patrick, Lang, Inish M, O'Doherty, Sarah E, David, Rhoda N, Muse, Stephen R, Karpen, Laura Sue, Song, Klaus, Romero, Jackson K, Burton
Publikováno v:
Clinical pharmacology and therapeutics. 111(5)
The development of therapies to prevent or delay the onset of type 1 diabetes (T1D) remains challenging, and there is a lack of qualified biomarkers to identify individuals at risk of developing T1D or to quantify the time-varying risk of conversion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4f03de962788cf469785da57c2d778b
https://pubmed.ncbi.nlm.nih.gov/35276013
https://pubmed.ncbi.nlm.nih.gov/35276013
Autor:
Stephen R, Karpen, Jessica L, Dunne, Brigitte I, Frohnert, Marjana, Marinac, Claudia, Richard, Sarah E, David, Inish M, O'Doherty
Publikováno v:
Diabetologia
The development of medical products that can delay or prevent progression to stage 3 type 1 diabetes faces many challenges. Of note, optimising patient selection for type 1 diabetes prevention clinical trials is hindered by significant patient hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a9816850f15d3f9e414cb84b685075b
https://pubmed.ncbi.nlm.nih.gov/35867129
https://pubmed.ncbi.nlm.nih.gov/35867129
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109546- (2024)
Summary: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous immune population with diverse immunosuppressive functions in solid tumors. Here, we explored the role of the tumor microenvironment in regulating MDSC differentiation and immunosu
Externí odkaz:
https://doaj.org/article/3cd85a25ea7a48bab9c5195f81deb7d5
Autor:
Peter Timmins, Carl H. Schwalbe, Kofi Asare-Addo, Miren Ramirez, Sarah E. David, Barbara R. Conway
Salt formation is used to optimize pharmaceutical properties for carboxylic acid drugs, but selection can often be empirical. An extended series of salts of the anti-hyperlipidaemia carboxylic acid drug gemfibrozil was prepared using a related series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d75c43adab14c4d41dd42a1734f2e57
Autor:
Marcin Pilarczyk, Mehdi Fazel-Najafabadi, Michal Kouril, Behrouz Shamsaei, Juozas Vasiliauskas, Wen Niu, Naim Mahi, Lixia Zhang, Nicholas A. Clark, Yan Ren, Shana White, Rashid Karim, Huan Xu, Jacek Biesiada, Mark F. Bennett, Sarah E. Davidson, John F. Reichard, Kurt Roberts, Vasileios Stathias, Amar Koleti, Dusica Vidovic, Daniel J. B. Clarke, Stephan C. Schürer, Avi Ma’ayan, Jarek Meller, Mario Medvedovic
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
There are only a few platforms that integrate multiple omics data types, bioinformatics tools, and interfaces for integrative analyses and visualization that do not require programming skills. Here the authors present an integrative web-based platfor
Externí odkaz:
https://doaj.org/article/08ffc15267ee4c3faac75343be39e39f
Publikováno v:
Journal of Pharmacy and Pharmacology. 62:1519-1525
Objectives Understanding the impact of the counterion on the properties of an acidic or basic drug may influence the choice of salt form, especially for less potent drugs with a high drug load per unit dose. The aim of this work was to determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2065cccee20c11b30576bdd5eefd4080
https://doi.org/10.1111/j.2042-7158.2010.01025.x
https://doi.org/10.1111/j.2042-7158.2010.01025.x
Publikováno v:
Journal of Solid State Chemistry. 180:1068-1075
We report the formation and structural properties of co-crystals containing gemfibrozil and hydroxy derivatives of t-butylamine H2NC(CH3)3−n(CH2OH)n, with n=0, 1, 2 and 3. In each case, a 1:1 co-crystal is formed, with transfer of a proton from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e020168b621de0d9b35c5667327469
https://doi.org/10.1016/j.jssc.2006.12.036
https://doi.org/10.1016/j.jssc.2006.12.036