Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarah E. Cummings"'
Autor:
Samantha F. Kornfeld, Sarah E. Cummings, Rebecca Yaworski, Yves De Repentigny, Sabrina Gagnon, Stephanie Zandee, Samaneh Fathi, Alexandre Prat, Rashmi Kothary
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelina
Externí odkaz:
https://doaj.org/article/44c7ebcf25614e2aabf92ea59d7493d9
Autor:
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity. This study aims to
Externí odkaz:
https://doaj.org/article/e9c74a4ae6444282ad687844f70ffab3
Autor:
Sarah E. Cummings, Sean P. Delaney, Frederic St-Denis Bissonnette, Andrew Stalker, Gauri Muradia, Jelica Mehic, Tyson E. Graber, Tommy Alain, Jessie R. Lavoie
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108708- (2024)
Summary: Extracellular vesicles (EVs) are entering the clinical arena as novel biologics for infectious diseases, potentially serving as the immunogenic components of next generation vaccines. However, relevant human assays to evaluate the immunogeni
Externí odkaz:
https://doaj.org/article/46998e4c994a4f13a53d86c66f5bea2f
Autor:
Frederic St‐Denis‐Bissonnette, Sarah E. Cummings, Shirley Qiu, Andrew Stalker, Gauri Muradia, Jelica Mehic, Karan Mediratta, Shelby Kaczmarek, Dylan Burger, Seung‐Hwan Lee, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) have shown promising potential as biotherapeutics for cancer due to their unique attributes as cytotoxic nanovesicles against cancer cells and immune‐modulatory activity towar
Externí odkaz:
https://doaj.org/article/1906ed4190454e6db53b02b8e2e4579a
Publikováno v:
Journal of Cellular Physiology. 236:997-1012
The roles of specific microRNAs (miRNA) in oligodendrocyte (OL) differentiation have been studied in depth. However, miRNAs in OL precursors and oligodendrocyte progenitor cells (OPCs) have been less extensively investigated. MiR-145-5p is highly exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ed100f78cf40a61b8f77fdfafff580
https://doi.org/10.1002/jcp.29910
https://doi.org/10.1002/jcp.29910
Publikováno v:
Journal of neurochemistry. 136(3)
Integrin-linked kinase (ILK), a focal adhesion protein, brokers the link between cytoskeleton, cell membrane, and extracellular environment. Here, we demonstrate a role for ILK in laminin-2-mediated adhesion in primary murine oligodendrocytes (OLs) -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed745d22e773fb15b013c548f1f020e
https://pubmed.ncbi.nlm.nih.gov/26614167
https://pubmed.ncbi.nlm.nih.gov/26614167
Autor:
Marc-Olivier Deguise, Rashmi Kothary, John-Paul Michalski, Sarah E. Cummings, Emily McFall, Ryan W. O'Meara, Sabrina Gibeault, Yves De Repentigny
Publikováno v:
Human Molecular Genetics. :ddw385
The childhood neurodegenerative disease spinal muscular atrophy (SMA) is caused by loss-of-function mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene resulting in insufficient levels of survival motor neuron (SMN) protein. Classically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38819a46348de37c227bfe1aacd3881a
https://doi.org/10.1093/hmg/ddw385
https://doi.org/10.1093/hmg/ddw385
Publikováno v:
BMC Neuroscience
Background The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucidating the mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa844fa7f6a9440f85fa55486a9a4336