Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sarah E. Blatt"'
Publikováno v:
Tissue Eng Part C Methods
The primary regulators of the innate immune response to implanted biomaterials are macrophages, which change phenotype over time to regulate multiple phases of the tissue repair process. Immunomodulatory biomaterials that target macrophage phenotype
Autor:
Teresa Dinter, Sarah E. Blatt, Leon Yim, Ellen Duong, Karl Dane Wittrup, Tim B. Fessenden, Emi Lutz, Arjun Bhutkar, Stefani Spranger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundConventional dendritic cells (cDC) are critical mediators of protective anti-tumor CD8+ T-cell responses.1 Batf3-driven DC1 are the predominant cDC subset driving anti-tumor immunity due to their specialized ability to cross-present antigen
Autor:
Jason M. Schenkel, Sara Z. Tavana, Michelle Hillman, Peter M. K. Westcott, Megan L. Burger, Sarah E. Blatt, Tyler Jacks, David Canner, Marta M. Holovatska, Michael Manos, Giorgio Gaglia, Izumi de los Rios Kobara, Aviv Regev, Alex M. Jaeger, Arjun Bhutkar, Sandro Santagata, William L. Hwang, F. Stephen Hodi, Cecily C. Ritch, Amanda M. Cruz, Tamina Kienka, Andrea Garmilla, Alexia L. Barandiaran, Amy Li, Grace E. Crossland
Publikováno v:
Cell
Summary CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881da5a74e035825ca947128bb7a8b0b
https://europepmc.org/articles/PMC8522630/
https://europepmc.org/articles/PMC8522630/
Autor:
Sarah E. Blatt, Izumi de los Rios Kobara, Aviv Regev, Arjun Bhutkar, David Canner, Sandro Santagata, Sara Z. Tavana, Amy Li, Jason M. Schenkel, Tyler Jacks, Grace E. Crossland, Michelle Hillman, Tamina Kienka, Peter M. K. Westcott, Andrea Garmilla, Giorgio Gaglia, William L. Hwang, Megan L. Burger, Cecily C. Ritch, Amanda M. Cruz
Publikováno v:
SSRN Electronic Journal.
CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about their interplay and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we find that immunodominance is established in
Autor:
Karl Dane Wittrup, Sarah E. Blatt, Leon Yim, Stefani Spranger, Tim B. Fessenden, Ellen Duong, Emi Lutz, Teresa Dinter, Arjun Bhutkar
Publikováno v:
Immunity. 55:308-323.e9
Summary Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing t
Autor:
Megan L. Burger, Amanda M. Cruz, Grace E. Crossland, Giorgio Gaglia, Cecily C. Ritch, Sarah E. Blatt, Arjun Bhutkar, Sara Z. Tavana, Sandro Santagata, Tyler Jacks
Publikováno v:
Cancer Immunology Research. 10:P010-P010
CD8 T cell responses against different tumor neoantigens occur simultaneously, yet it is unclear whether they interact to potentiate or antagonize the overall anti-tumor response. In a genetically engineered mouse model of lung adenocarcinoma, we fin
Publikováno v:
Biointerphases. 12(2)
Intervertebral disk degeneration is one of the most significant contributors to low back pain. Thus, there is significant interest in designing new treatments and nucleus pulposus (NP) tissue replacements. Herein, the authors propose a biosynthetic m