Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah E. Alford"'
Autor:
Timothy C. Chambers, J.H. Frederik Falkenburg, Inge Jedema, Robert L. Saylors, Henriette M. Goselink, Nandini Sakurikar, Joshua M. Eichhorn, Floris C. Loeff, Anisha Kothari, Sarah E. Alford
Supplemental Figure 4: Pro-apoptotic Bcl-2 family proteins are absent in β-actin immunoprecipitates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343173d2b04f926988b37e8b157cdb09
https://doi.org/10.1158/0008-5472.22407402
https://doi.org/10.1158/0008-5472.22407402
Autor:
Timothy C. Chambers, J.H. Frederik Falkenburg, Inge Jedema, Robert L. Saylors, Henriette M. Goselink, Nandini Sakurikar, Joshua M. Eichhorn, Floris C. Loeff, Anisha Kothari, Sarah E. Alford
Supplemental Figure 1: Primary ALL cells are highly sensitive to ABT-263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9935fc563f15917a2fedd213b7031eac
https://doi.org/10.1158/0008-5472.22407411
https://doi.org/10.1158/0008-5472.22407411
Autor:
Timothy C. Chambers, J.H. Frederik Falkenburg, Inge Jedema, Robert L. Saylors, Henriette M. Goselink, Nandini Sakurikar, Joshua M. Eichhorn, Floris C. Loeff, Anisha Kothari, Sarah E. Alford
Portions of Methods and Materials and supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61348b58f32c9c2a9b54e8c2546fd62f
https://doi.org/10.1158/0008-5472.22407396.v1
https://doi.org/10.1158/0008-5472.22407396.v1
Autor:
Timothy C. Chambers, J.H. Frederik Falkenburg, Inge Jedema, Robert L. Saylors, Henriette M. Goselink, Nandini Sakurikar, Joshua M. Eichhorn, Floris C. Loeff, Anisha Kothari, Sarah E. Alford
Supplemental Figure 3: BH3 mimetics induce rapid apoptotic death in primary ALL cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172f243c94c631e164489d1437187f69
https://doi.org/10.1158/0008-5472.22407405.v1
https://doi.org/10.1158/0008-5472.22407405.v1
Autor:
Katherine Hart, Timothy C. Chambers, Samuel G. Mackintosh, Rong Chu, Matthew R. Kovak, Sarah E. Alford, Anisha Kothari
Publikováno v:
Oncotarget
// Rong Chu 1, * , Sarah E. Alford 1, * , Katherine Hart 1 , Anisha Kothari 1 , Samuel G. Mackintosh 1 , Matthew R. Kovak 1 , Timothy C. Chambers 1 1 Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Littl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cad93c1a497ab75eec95f5db7c9e37
https://doi.org/10.18632/oncotarget.12586
https://doi.org/10.18632/oncotarget.12586
Publikováno v:
Experimental Cell Research. 322:415-424
Bcl-2 family proteins act as essential regulators and mediators of intrinsic apoptosis. Several lines of evidence suggest that the anti-apoptotic members of the family, including Bcl-2, Bcl-xL and Mcl-1, exhibit functional redundancy. However, the cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88501db421e5831cc5616efe74ecf1f8
https://doi.org/10.1016/j.yexcr.2014.02.010
https://doi.org/10.1016/j.yexcr.2014.02.010
Publikováno v:
Cancer Letters. 343:232-238
This study examined the molecular mechanism of action of anti-mitotic drugs. The hypothesis was tested that death in mitosis occurs through sustained mitotic arrest with robust Cdk1 signaling causing complete phosphorylation of Mcl-1 and Bcl-xL, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc936e30d1c47aac9f700c62a0945bc
https://doi.org/10.1016/j.canlet.2013.09.036
https://doi.org/10.1016/j.canlet.2013.09.036
Autor:
Sarah E. Alford, Robert L. Saylors, Nandini Sakurikar, Floris C. Loeff, H. M. Goselink, Inge Jedema, Anisha Kothari, Joshua M. Eichhorn, Timothy C. Chambers, J.H. Frederik Falkenburg
Publikováno v:
Cancer Research, 75(7), 1366-1375
BH3 mimetic drugs may be useful to treat acute lymphoblastic leukemia (ALL) but the sensitivity of primary tumor cells has not been fully evaluated. Here, B-lineage ALL cell cultures derived from a set of primary tumors were studied with respect to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158a79665ad274b32156f500bb2757c9
https://hdl.handle.net/1887/105611
https://hdl.handle.net/1887/105611
Autor:
Timothy C. Chambers, Chambers C. Hughes, William Fenical, Joshua M. Eichhorn, Sarah E. Alford
Publikováno v:
Cell Death & Disease
The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-X(L) and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. Whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032ef68a36c4bfc6938fd15ba327ccf3
https://doi.org/10.1038/cddis.2013.411
https://doi.org/10.1038/cddis.2013.411
Publikováno v:
Cell Death & Disease
Microtubule inhibiting agents (MIAs) characteristically induce phosphorylation of the major anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2 and Bcl-xL, and although this leads to Mcl-1 degradation, the role of Bcl-2/Bcl-xL phosphorylation in mitotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a85e213b5e8a045cf11510b59c75103
https://doi.org/10.1038/cddis.2013.360
https://doi.org/10.1038/cddis.2013.360