Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarah E Trewick"'
Autor:
Xavier Fradera, Meredeth A. McGowan, Mangeng Cheng, Pravien Abeywickrema, Karin M. Otte, Prasanthi Geda, Nunzio Sciammetta, Catherine White, Konstanze von Köenig, Charles A. Lesburg, Hyun Chong Woo, Nadya Smotrov, Sarah E Trewick, Patrick J. Curran, Martin Augustin, Christine Andrews, Elizabeth Joshi, Wensheng Yu, Elliott B. Nickbarg, Phillip M. Cowley, Ian Knemeyer, Jongwon Lim, Hua Zhou, Yongxin Han, Xuelei Song, David Jonathan Bennett, Mee Ra Heo, Peter Spacciapoli, J. Richard Miller
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as a target of significant interest to the field of cancer immunotherapy, as the upregulation of IDO1 in certain cancers has been linked to host immune evasion and poor prognosis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581b064473f176e3696647f1e7fc716c
https://europepmc.org/articles/PMC7153270/
https://europepmc.org/articles/PMC7153270/
Publikováno v:
Journal for Immunotherapy of Cancer
The enzymes tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO1) catalyse oxidation of the essential amino acid tryptophan (Trp) leading to the formation of immunosuppressive kynurenine (Kyn) pathway metabolites that dampen the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df9ad2d08242ffed8c33f31d7e06f64
https://doi.org/10.1186/2051-1426-3-s2-p422
https://doi.org/10.1186/2051-1426-3-s2-p422
