Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sarah E Nicholas"'
Autor:
Sarah E Nicholas, Tyler G Rowsey, Shrestha Priyadarsini, Nawajes A Mandal, Dimitrios Karamichos
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182390 (2017)
To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-β) in order to develop novel, non-invasive therapies.Human corneal fibroblasts (HCFs) were harvested from healthy donor
Externí odkaz:
https://doaj.org/article/93dd6d9cb89c452d8e98887939e5a40d
Autor:
Paulina Escandon, Alexander J. Choi, Steve Mabry, Sarah E. Nicholas, Rebecca L. Cunningham, Liam Redden, David A. Murphy, Kamran M. Riaz, Tina B. McKay, Dimitrios Karamichos
Publikováno v:
Cells, Vol 13, Iss 20, p 1704 (2024)
Keratoconus (KC) is a corneal thinning dystrophy that leads to visual impairment. While the cause of KC remains poorly understood, changes in sex hormone levels have been correlated with KC development. This study investigated circulating gonadotropi
Externí odkaz:
https://doaj.org/article/75c9fa459c04446d85a62ad3d1de931a
Autor:
Lyly Van, BSc, Sashia Bennett, MD, PhD, Sarah E. Nicholas, BSc, Jesper Hjortdal, MD, DMSc, Tina B. McKay, PhD, Dimitrios Karamichos, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 2, Pp 100364- (2024)
Purpose: To evaluate associations between hormone levels and corneal parameters in patients with keratoconus (KC), before and after photooxidative corneal collagen crosslinking (CXL). Design: Prospective, observational cohort study. Participants: Twe
Externí odkaz:
https://doaj.org/article/f00844bb48694ad4a60373283b9ada6c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Corneal innervation plays a major role in the pathobiology of diabetic corneal disease. However, innervation impact has mainly been investigated in the context of diabetic epitheliopathy and wound healing. Further studies are warranted in th
Externí odkaz:
https://doaj.org/article/e371bc0601aa45068d729c0d4278fd22
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 696 (2023)
Collagen crosslinking (CXL) is a widely used treatment to halt the progression of keratoconus (KC). Unfortunately, a significant number of patients with progressive KC will not qualify for CXL, including those with corneas thinner than 400 µm. The p
Externí odkaz:
https://doaj.org/article/b427496ff2814824b95806ccd0023863
Autor:
Pawan Shrestha, Amy E. Whelchel, Sarah E. Nicholas, Wentao Liang, Jian-Xing Ma, Dimitrios Karamichos
Publikováno v:
Analytical Cellular Pathology, Vol 2022 (2022)
Diabetes mellitus (DM) is a group of metabolic diseases that is known to cause structural and functional ocular complications. In the human cornea, DM-related complications affect the epithelium, stroma, and nerves. Monocarboxylate transporters (MCTs
Externí odkaz:
https://doaj.org/article/5e3b1d32b0544f97af8c6e36a9cac05a
Autor:
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal
Publikováno v:
Cells, Vol 11, Iss 18, p 2914 (2022)
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV). Wild-type (WT) and Sphk1 knockout (Sphk1−/−) mice received corneal alkali-bu
Externí odkaz:
https://doaj.org/article/07d0c106e39545e7a45025e96dd8d00b
Autor:
Sarah E. Nicholas, MD, Wei Fu, MSc, Angela L. Liang, Regina DeLuna, MD, Luka Vujaskovic, Justin Bishop, MD, Brandi R. Page, MD, Harry Quon, MD, Christine Gourin, MD, Carole Fakhry, MD, David Eisele, MD, Ana P. Kiess, MD, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 3, Pp 100674- (2021)
Purpose: Pleomorphic adenoma is a benign salivary tumor that may recur multifocally. In case series, the benefit of radiation therapy (RT) for recurrent pleomorphic adenoma remains unclear. We hypothesized that the combination of surgery and adjuvant
Externí odkaz:
https://doaj.org/article/d0ee073d55914a0a88e9421f1b3a1dda
Autor:
Tina B. McKay, Pouriska B. Kivanany, Sarah E. Nicholas, Okhil K. Nag, Michael H. Elliott, W. Matthew Petroll, Dimitrios Karamichos
Publikováno v:
Metabolites, Vol 12, Iss 7, p 626 (2022)
We have previously reported the flavonoid, quercetin, as a metabolic regulator and inhibitor of myofibroblast differentiation in vitro. Our current study evaluated the effects of topical application of quercetin on corneal scar development using two
Externí odkaz:
https://doaj.org/article/81857624c50643118d973e5deb18d97a
Publikováno v:
Analytical Cellular Pathology, Vol 2021 (2021)
Diabetic keratopathy is a corneal complication of diabetes mellitus (DM). Patients with diabetic keratopathy are prone to developing corneal haze, scarring, recurrent erosions, and significant wound healing defects/delays. The purpose of this study w
Externí odkaz:
https://doaj.org/article/0315c89e88164973b454f3162e8cd4ef