Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sarah E Conduit"'
Autor:
Sarah E. Conduit, Wayne Pearce, Amandeep Bhamra, Benoit Bilanges, Laura Bozal-Basterra, Lazaros C. Foukas, Mathias Cobbaut, Sandra D. Castillo, Mohammad Amin Danesh, Mahreen Adil, Arkaitz Carracedo, Mariona Graupera, Neil Q. McDonald, Peter J. Parker, Pedro R. Cutillas, Silvia Surinova, Bart Vanhaesebroeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Primary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the proc
Externí odkaz:
https://doaj.org/article/73d0a1177d1d4ad6bd109cda96644ef1
Autor:
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse mode
Externí odkaz:
https://doaj.org/article/226bfb45e8934ee1ba253ad4552b6197
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
Autor:
Sarah E. Conduit, Elizabeth M. Davies, Alex J. Fulcher, Viola Oorschot, Christina A. Mitchell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment o
Externí odkaz:
https://doaj.org/article/fb8468d7a7d848198f306db1e3a4ec54
Autor:
Christina Anne Mitchell, Elizabeth M Davies, Alex J. Fulcher, Viola Oorschot, Sarah E Conduit
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Primary cilia are evolutionary conserved microtubule-based organelles that protrude from the surface of most mammalian cells. Phosphoinositides (PI) are membrane-associated signaling lipids that regulate numerous cellular events via the recruitment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4acc13747ec35a886e0aae15d23ff65
http://europepmc.org/articles/PMC8120242
http://europepmc.org/articles/PMC8120242
Autor:
Marc Remke, Vijay Ramaswamy, Christina Anne Mitchell, Sarah E Conduit, Michael D. Taylor, Brandon J. Wainwright, Jennifer M Dyson, D N Watkins
Publikováno v:
Oncogene. 36:5969-5984
Sonic Hedgehog (SHH) signaling at primary cilia drives the proliferation and progression of a subset of medulloblastomas, the most common malignant paediatric brain tumor. Severe side effects associated with conventional treatments and resistance to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b756e165e40a3534d24cd5ad6dd61175
https://doi.org/10.1038/onc.2017.208
https://doi.org/10.1038/onc.2017.208
Autor:
Christina Anne Mitchell, Sandra J Feeney, Helen E. Abud, Sarah E Conduit, Lisa M Ooms, Jennifer M Dyson, Sandra Hakim
Publikováno v:
Human Molecular Genetics.
Polycystic kidney disease (PKD) results from excessive renal epithelial cell proliferation, leading to the formation of large fluid filled cysts which impair renal function and frequently lead to renal failure. Hyperactivation of numerous signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b561f13f306c2101bf4a59d3a74c5537
https://doi.org/10.1093/hmg/ddy309
https://doi.org/10.1093/hmg/ddy309
Autor:
Bernadette, Carroll, Glyn, Nelson, Yoana, Rabanal-Ruiz, Olena, Kucheryavenko, Natasha A, Dunhill-Turner, Charlotte C, Chesterman, Qabil, Zahari, Tong, Zhang, Sarah E, Conduit, Christina A, Mitchell, Oliver D K, Maddocks, Penny, Lovat, Thomas, von Zglinicki, Viktor I, Korolchuk
Publikováno v:
The Journal of Cell Biology
It is unclear how mTORC1 signaling differs in senescent and young cells. Carroll et al. show that senescence leads to constitutive mTORC1 activation and resistance to serum and amino acid starvation. This is associated with elevated autophagy, depola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::673596468061702af9a8d1ee7f824fcf
https://pubmed.ncbi.nlm.nih.gov/28566325
https://pubmed.ncbi.nlm.nih.gov/28566325
Autor:
Rajendra Gurung, Kristy A. Horan, Alex J. Fulcher, Absorn Sriratana, Carol Wicking, Georg Ramm, Tia DiTommaso, Sandra Hakim, Ian M. Smyth, Sarah E Conduit, Sandra J Feeney, Christina Anne Mitchell, Jennifer M Dyson
Publikováno v:
The Journal of Cell Biology
Dyson et al. demonstrate that the inositol polyphosphate 5-phosphatase INPP5E is essential for Hedgehog-dependent embryonic development. By regulating PI(4,5)P2 and PI(3,4,5)P3 signals at cilia, INPP5E contributes to cilia transition zone function an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6132dcd0e1a60df9b4fbdfa3d17f553
https://pubmed.ncbi.nlm.nih.gov/27998989
https://pubmed.ncbi.nlm.nih.gov/27998989
Autor:
Sandra Hakim, Jennifer M Dyson, Seongjin Seo, Denny L Cottle, Ian M. Smyth, Olga V. Plotnikova, Christina Anne Mitchell, Sarah E Conduit
Publikováno v:
Journal of cell science. 128(2)
Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood. Here, we describe an interaction between INPP5E and AURKA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de1d54c233345b10ddbeea81eae823a
https://pubmed.ncbi.nlm.nih.gov/25395580
https://pubmed.ncbi.nlm.nih.gov/25395580