Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sarah E Clarke"'
Autor:
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N.J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105409- (2022)
Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related mole
Externí odkaz:
https://doaj.org/article/bc9bfc65a4564f5b8c32bca349dccceb
Autor:
Moritz Jakob Przybilla, Amany Ammar, Ryan Chuen Khaw, Andrew R. Lawson, Pantelis Nicola, Kate Davies, Zoe Frazer, Kate H. Gowers, Timothy M. Butler, Sarah E. Clarke, Inigo Martincorena, Sam M. Janes, Peter J. Campbell
Publikováno v:
Cancer Research. 83:218-218
The diversity in somatic variation across human tissues outshining human cancers has only recently been started to be appreciated. In particular, healthy individuals carry large numbers of cells and clonal expansions with mutations in driver genes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae34e2ec1965198c269b3de6a7645e5
https://doi.org/10.1158/1538-7445.am2023-218
https://doi.org/10.1158/1538-7445.am2023-218
Autor:
Peter J. Campbell, Adam Pennycuick, Inigo Martincorena, Kenichi Yoshida, Andrew Menzies, Tomonori Hirano, Ricky Thakrar, Sarah E. Clarke, Nobuyuki Kakiuchi, Colin R. Butler, Henry Lee-Six, Sam M. Janes, Kathryn Beal, Tim H. H. Coorens, Elizabeth Anderson, Michael R. Stratton, Kate H.C. Gowers, Elizabeth F. Maughan, Robert E. Hynds, Fraser R. Millar, Deepak P. Chandrasekharan
Publikováno v:
Nature. 578:266-272
Tobacco smoking causes lung cancer1–3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6–10, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd71989032b18cec95132d877481f7c
https://doi.org/10.1038/s41586-020-1961-1
https://doi.org/10.1038/s41586-020-1961-1
Autor:
Kim B. Jensen, Sandra Gómez-López, Adam Pennycuick, Ahmed S. N. Alhendi, Laura Succony, Derek Davies, Kate H.C. Gowers, Nicholas A. Wright, Sam M. Janes, Sarah E. Clarke
Publikováno v:
Succony, L, Gómez-López, S, Pennycuick, A, Alhendi, A S N, Davies, D, Clarke, S E, Gowers, K H C, Wright, N A, Jensen, K B & Janes, S M 2022, ' Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth ', European Respiratory Journal, vol. 59, 2000816 . https://doi.org/10.1183/13993003.00816-2020
BackgroundLung squamous cell carcinoma (LUSC) accounts for a significant proportion of cancer deaths worldwide, and is preceded by the appearance of progressively disorganised pre-invasive lesions in the airway epithelium. Yet the biological mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bc4b6b060200e4112f574104cd276e
https://curis.ku.dk/portal/da/publications/lrig1-expression-identifies-airway-basal-cells-with-high-proliferative-capacity-and-restricts-lung-squamous-cell-carcinoma-growth(19158daa-0781-4fc7-afb2-694cf6b6c016).html
https://curis.ku.dk/portal/da/publications/lrig1-expression-identifies-airway-basal-cells-with-high-proliferative-capacity-and-restricts-lung-squamous-cell-carcinoma-growth(19158daa-0781-4fc7-afb2-694cf6b6c016).html
Autor:
Kate H. Gowers, Sarah E. Clarke, Ayu Hutami Syaraf, Kenichi Yoshida, Moritz J. Przybilla, Hugh Selway, Adam Pennycuick, Peter J. Campbell, Sam M. Janes
Publikováno v:
Cancer Research. 82:3158-3158
It is well established that tobacco smoking causes lung cancer and this is thought to be the result of a progressive accumulation of genomic mutations induced by tobacco smoke exposure; however, until recently a detailed understanding of the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e6ec2c5e4c0c36b40ef26e39e53f13
https://doi.org/10.1158/1538-7445.am2022-3158
https://doi.org/10.1158/1538-7445.am2022-3158
Autor:
Sarah E. Clarke
Publikováno v:
Valvular Heart Disease ISBN: 9783030862329
Valvular Heart Disease
Valvular Heart Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cabfc8c6ee0ca9f6a398b72043fef620
https://doi.org/10.1007/978-3-030-86233-6_5
https://doi.org/10.1007/978-3-030-86233-6_5
Autor:
Elizabeth M. Perpetua, Martina K. Speight, Sarah E. Clarke, Kimberly Guibone, Patricia Keegan
Publikováno v:
Structural Heart. 3:201-210
Background: In professional society consensus statements for structural heart disease (SHD), the Coordinator is identified as a key member of the Multidisciplinary Team (MDT). Minimal information i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3aced3633c263e1e14454e471d35887
https://doi.org/10.1080/24748706.2019.1581962
https://doi.org/10.1080/24748706.2019.1581962
Autor:
Henry Hui, Kathy A Fuller, Luna Eresta Jaya, Yusuke Konishi, Teng Fong Ng, Richard Frodsham, Graham Speight, Kazuhiro Yamada, Sarah E Clarke, Wendy N Erber
Publikováno v:
Journal of Clinical Pathology. :jclinpath-2022
AimsCytogenetic abnormalities involving the IGH gene are seen in up to 55% of patients with multiple myeloma. Current testing is performed manually by fluorescence in situ hybridisation (FISH) on purified plasma cells. We aimed to assess whether an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96dcf4e5a07e5383084abe8cbb007a51
https://doi.org/10.1136/jcp-2022-208230
https://doi.org/10.1136/jcp-2022-208230
Autor:
Sarah E. Clarke, D Phylactopoulos, Manuela Platé, Rachel C. Chambers, Robert E. Hynds, Sam M. Janes
Publikováno v:
03.03 - Mechanisms of lung injury and repair.
Background: Type 2 alveolar epithelial cells (AEC2) are stem cells of the lung alveoli. Impaired renewal capacity of AEC2, the persistence of extracellular matrix producing myofibroblasts and the highly dysregulated cross-talk between these two cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ac3d0b2cad08388e377c0c4f4f331bd
https://doi.org/10.1183/23120541.lsc-2021.95
https://doi.org/10.1183/23120541.lsc-2021.95
Publikováno v:
Respiratory science: state of the art.
Introduction Recent work has shown that tobacco smoke exposure increases the mutational burden and cell-to-cell mutational heterogeneity of the normal bronchial epithelium. However, smoking cessation allows the preferential expansion of low-mutant ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfed67cc31e585732a87b262a178f7f
https://doi.org/10.1136/thorax-2020-btsabstracts.54
https://doi.org/10.1136/thorax-2020-btsabstracts.54