Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarah E Boyce"'
Autor:
Sarah E Boyce, Neeraj Tirunagari, Anita Niedziela-Majka, Jason Perry, Melanie Wong, Elaine Kan, Leanna Lagpacan, Ona Barauskas, Magdeleine Hung, Martijn Fenaux, Todd Appleby, William J Watkins, Uli Schmitz, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84808 (2014)
Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition i
Externí odkaz:
https://doaj.org/article/511db7137be1485baa683530d590daed
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69153 (2013)
A key challenge in structure-based discovery is accounting for modulation of protein-ligand interactions by ordered and bulk solvent. To investigate this, we compared ligand binding to a buried cavity in Cytochrome c Peroxidase (CcP), where affinity
Externí odkaz:
https://doaj.org/article/07bacfd256e44df9b1f1b67f47b93e97