Výsledky vyhledávání - "Sarah E Belisle"

Akademický článek

A systems biology approach reveals that tissue tropism to West Nile virus is regulated by antiviral genes and innate immune cellular processes.

Autor: Mehul S Suthar, Margaret M Brassil, Gabriele Blahnik, Aimee McMillan, Hilario J Ramos, Sean C Proll, Sarah E Belisle, Michael G Katze, Michael Gale

Publikováno v: PLoS Pathogens, Vol 9, Iss 2, p e1003168 (2013)

The actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking RLR or IFN signaling pathways, WN

Externí odkaz: https://doaj.org/article/85948703cf5344418ca759d793a6098e

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Akademický článek

Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine.

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e19681 (2011)

While HIV-1-specific cellular immunity is thought to be critical for the suppression of viral replication, the correlates of protection have not yet been determined. Rhesus macaques (RM) are an important animal model for the study and development of

Externí odkaz: https://doaj.org/article/832e20b4e604483faf325caae46dd2dc

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Akademický článek

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Publikováno v: mBio, Vol 4, Iss 4 (2013)

ABSTRACT Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unb

Externí odkaz: https://doaj.org/article/e5a4def1db8b49f4b6a1891e28591907

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Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses

Autor: Sarah E. Belisle, Terrence M. Tumpey, Yu Li, Michael G. Katze, Carole R. Baskin, Jiangning Li

Publikováno v: Virology. 421:105-113

Infections with highly pathogenic H5N1 avian (HPAI) and 1918 pandemic H1N1 influenza viruses cause uncontrolled local and systemic inflammation. The mechanism for this response is poorly understood, despite its importance as a determinant of virulenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070eeff634a7aee475a952bc123f08c
https://doi.org/10.1016/j.virol.2011.09.011

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Systems Virology Identifies a Mitochondrial Fatty Acid Oxidation Enzyme, Dodecenoyl Coenzyme A Delta Isomerase, Required for Hepatitis C Virus Replication and Likely Pathogenesis

Autor: Deborah L. Diamond, Melissa M. Matzke, Katrina M. Waters, Sarah E. Belisle, Richard D. Smith, Thomas O. Metz, Michael G. Katze, Angela L. Rasmussen, Marcus J. Korth, Xiaoli Gao, Jason E. McDermott, Victoria S. Carter

Publikováno v: Journal of Virology. 85:11646-11654

We previously employed systems biology approaches to identify the mitochondrial fatty acid oxidation enzyme dodecenoyl coenzyme A delta isomerase (DCI) as a bottleneck protein controlling host metabolic reprogramming during hepatitis C virus (HCV) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad5a524271ade562031fa7309d76db8
https://doi.org/10.1128/jvi.05605-11

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2009 Pandemic H1N1 Influenza Virus Causes Disease and Upregulation of Genes Related to Inflammatory and Immune Responses, Cell Death, and Lipid Metabolism in Pigs

Autor: Jake Elder, Sarah E. Belisle, Qinfang Liu, Wenjun Ma, Chuanling Qiao, Juergen A. Richt, Derek A. Mosier, Michael G. Katze, Richard J. Webby, X. Li, Evelyn Stigger-Rosser

Publikováno v: Journal of Virology. 85:11626-11637

There exists limited information about whether adaptation is needed for cross-species transmission of the 2009 pandemic H1N1 influenza virus (pH1N1). Here, we compare the pathogenesis of two pH1N1 viruses, one derived from a human patient (A/CA/04/09

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafd133d02f004418b0103b167690a4c
https://doi.org/10.1128/jvi.05705-11

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Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-α) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-α Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection

Autor: Mary J. Pantin-Jackwood, Jennifer R. Tisoncik, Victoria S. Carter, David E. Swayne, Michael G. Katze, Terrence M. Tumpey, Marcus J. Korth, Sean Proll, Sarah E. Belisle

Publikováno v: Journal of Virology. 84:12576-12588

The influenza pandemic of 1918 to 1919 was one of the worst global pandemics in recent history. The highly pathogenic nature of the 1918 virus is thought to be mediated in part by a dysregulation of the host response, including an exacerbated proinfl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87da19cb86728f3d0d9e5d997d39bf3
https://doi.org/10.1128/jvi.01310-10

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IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents

Autor: Jose M. Ordovas, Paul F. Jacques, Davidson H. Hamer, Sarah E. Belisle, Lynette S. Leka, Simin Nikbin Meydani, Basil C. Fine, Javier Delgado-Lista, Gerard E. Dallal

Publikováno v: The American Journal of Clinical Nutrition

Background: Vitamin E supplementation may be a potential strategy to prevent respiratory tract infections (RIs) in the elderly. The efficacy of vitamin E supplementation may depend on individual factors including specific single nucleotide polymorphi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c2930b4129e0f8f7d14608cce98e4d
https://doi.org/10.3945/ajcn.2010.29207

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Is systems biology the key to preventing the next pandemic?

Autor: Sarah E. Belisle, Jennifer R. Tisoncik, Michael G. Katze, Marcus J. Korth, Deborah L. Diamond

Publikováno v: Future Virology

Sporadic outbreaks of epizootics including SARS coronavirus and H5N1 avian influenza remind us of the potential for communicable diseases to quickly spread into worldwide epidemics. To confront emerging viral threats, nations have implemented strateg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a243934ea71751096b71d32a1432b6f

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