Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sarah E, Johnstone"'
Autor:
Allison P. Siegenfeld, Shelby A. Roseman, Heejin Roh, Nicholas Z. Lue, Corin C. Wagen, Eric Zhou, Sarah E. Johnstone, Martin J. Aryee, Brian B. Liau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors developed ‘Lamina-Inducible Methylation and Hi-C’ (LIMe-Hi-C) to simultaneously measure chromosome conformation, DNA methylation, and nuclear lamina positioning. Application of the method revealed dynamic changes upon PRC2 inhibi
Externí odkaz:
https://doaj.org/article/0dbe0b6e225542a5b5d44d310c2d1f55
Publikováno v:
Science (New York, N.Y.). 378(6626)
Global methylation changes in aging cells affect cancer risk and tissue homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c3fd2728b373651bc26ca08142e186
https://pubmed.ncbi.nlm.nih.gov/36548410
https://pubmed.ncbi.nlm.nih.gov/36548410
Autor:
Samantha M. Bevill, Salvador Casaní-Galdón, Chadi A. El Farran, Eli G. Cytrynbaum, Kevin A. Macias, Sylvie E. Oldeman, Kayla J. Oliveira, Molly M. Moore, Esmat Hegazi, Carmen Adriaens, Fadi J. Najm, George D. Demetri, Sonia Cohen, John T. Mullen, Nicolò Riggi, Sarah E. Johnstone, Bradley E. Bernstein
Publikováno v:
Cell Genomics. :100321
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8ee32ce2a58690034bd657094e3319
https://doi.org/10.1016/j.xgen.2023.100321
https://doi.org/10.1016/j.xgen.2023.100321
Autor:
Gilbert J. Rahme, Nauman M. Javed, Kaitlyn L. Puorro, Shouhui Xin, Volker Hovestadt, Sarah E. Johnstone, Bradley E. Bernstein
Publikováno v:
Cancer Research. 83:3479-3479
Epigenetic lesions that disrupt gene regulatory elements and expression are increasingly recognized as potential drivers of human cancers. However, we currently lack the in vitro and in vivo models required to functionally validate such lesions and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b14bd8dbe997da866581e6aa80617e7
https://doi.org/10.1158/1538-7445.am2023-3479
https://doi.org/10.1158/1538-7445.am2023-3479
Autor:
Nauman M. Javed, Jason L. Hornick, Ewa Sicinska, Bradley E. Bernstein, Prafulla C. Gokhale, Benjamin K. Eschle, George D. Demetri, Esmat Hegazi, Matthew L. Hemming, Daniel R. Tarjan, Chandrajit P. Raut, Yotam Drier, Sarah J. Shareef, William A. Flavahan, Sarah E. Johnstone
Publikováno v:
Nature
Epigenetic aberrations are widespread in cancer, yet the underlying mechanisms and causality remain poorly understood1–3. A subset of gastrointestinal stromal tumours (GISTs) lack canonical kinase mutations but instead have succinate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e025a723c36f280f5610b300e74df6
https://doi.org/10.1038/s41586-019-1668-3
https://doi.org/10.1038/s41586-019-1668-3
Autor:
Sally R. Williams, Priscilla K. Brastianos, Matthew R. Strickland, Ian M. Silverman, Matthew P. Frosch, Corey M. Gill, Kaitlin Hoang, Alexander Kaplan, Naema Nayyar, Heather Ely, Jason Christiansen, Ivanna Bihun, Fred G. Barker, Megan R. D'Andrea, Melanie Babinski, Tyler T. Lazaro, Sarah E. Johnstone, Daniel P. Cahill, Brandyn A. Castro, Tareq A. Juratli, Emily Batchelor
Publikováno v:
Journal of Neurological Surgery Part B: Skull Base. 80:562-567
Objective Posterior fossa meningiomas are surgically challenging tumors that are associated with high morbidity and mortality. We sought to investigate the anatomical distribution of clinically actionable mutations in posterior fossa meningioma to fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b36cdfb4fb5ae8a6b24dd59168f3d70
https://doi.org/10.1055/s-0038-1676821
https://doi.org/10.1055/s-0038-1676821
Autor:
Pawel Kurzawa, Vikram Deshpande, Ivan Chebib, Gunnlaugur P. Nielsen, Sarah E. Johnstone, John T. Mullen, Yen-Lin Chen
Publikováno v:
Am J Surg Pathol
Myogenic differentiation (MD) has been claimed to be a poor prognostic factor in dedifferentiated liposarcoma (DDLPS). To validate this, the prognostic significance of MD in a uniformly treated cohort of DDLPS was assessed. A cohort of patients that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434d14cdeb5566acda501636a6f02593
https://europepmc.org/articles/PMC8046521/
https://europepmc.org/articles/PMC8046521/
Autor:
Bradley E. Bernstein, Martin J. Aryee, Alejandro Reyes, Bin Zhang, Sarah E. Johnstone, Yifeng Qi
Publikováno v:
Biophys J
Chromosomes are positioned non-randomly inside the nucleus to coordinate with their transcriptional activity. The molecular mechanisms that dictate the global genome organization and the nuclear localization of individual chromosomes are not fully un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c857491cec20166fbb5e8e6f7fe1fa
https://pubmed.ncbi.nlm.nih.gov/33086041
https://pubmed.ncbi.nlm.nih.gov/33086041
Autor:
Noam Shoresh, Yifeng Qi, Esmat Hegazi, Sowmya Iyer, Luli S. Zou, Nir Hacohen, Bin Zhang, Vivian Hecht, Martin K. Selig, Caleb A. Lareau, Yotam Drier, Rafael A. Irizarry, Eric F. Joyce, Karin Pelka, Bradley E. Bernstein, Son C. Nguyen, Jonathan H. Chen, Martin J. Aryee, Alejandro Reyes, Sarah E. Johnstone, Carmen Adriaens
Publikováno v:
Cell
Widespread changes to DNA methylation and chromatin are well documented in cancer, but the fate of higher-order chromosomal structure remains obscure. Here we integrated topological maps for colon tumors and normal colons with epigenetic, transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572dc137cbfc3caf5dccd436be51f70a
https://doi.org/10.1038/s41568-020-00305-1
https://doi.org/10.1038/s41568-020-00305-1
Autor:
Sally R, Williams, Tareq A, Juratli, Brandyn A, Castro, Tyler T, Lazaro, Corey M, Gill, Naema, Nayyar, Matthew R, Strickland, Melanie, Babinski, Sarah E, Johnstone, Matthew P, Frosch, Ian M, Silverman, Heather A, Ely, Alexander B, Kaplan, Megan R, D'Andrea, Ivanna V, Bihun, Kaitlin, Hoang, Emily, Batchelor, Jason, Christiansen, Daniel P, Cahill, Frederick G, Barker, Priscilla K, Brastianos
Publikováno v:
J Neurol Surg B Skull Base
Objective Posterior fossa meningiomas are surgically challenging tumors that are associated with high morbidity and mortality. We sought to investigate the anatomical distribution of clinically actionable mutations in posterior fossa meningioma to fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d8de515148a824ef563ab984cf7f8a8
https://pubmed.ncbi.nlm.nih.gov/31750041
https://pubmed.ncbi.nlm.nih.gov/31750041