Výsledky vyhledávání - "Sarah Dysart"

A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

Autor: Carlos Stahlhut, Esteban A. Orellana, Kevin Kelnar, Xiaowei Chen, Andrea L. Kasinski, Frank J. Slack, Eliot Shimer, Andreas G. Bader, Sarah Dysart, Jane Zhao

Publikováno v: Oncogene

Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3257e5bf836dddcdf25444ffe25a5698
http://europepmc.org/articles/PMC4345154

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Abstract 5636: Preclinical data of a microRNA-based therapy for hepatocellular carcinoma

Autor: David R. Brown, Andreas G. Bader, Sarah Dysart, Neil Leatherbury, Paul Lammers, Christopher L. Daige, Jason F. Wiggins, Michael Omotola, Kevin Kelnar, Leslie Priddy, Jane Zhao, Jay Stoudemire

Publikováno v: Cancer Research. 72:5636-5636

MicroRNA (miRNA) mimics have emerged as a novel class of therapeutics with promising anti-oncogenic activity. These mimics are modeled after naturally occurring tumor suppressor miRNAs that are ubiquitously expressed in normal cells but frequently sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09204f55746addc22e1b3873036424cf
https://doi.org/10.1158/1538-7445.am2012-5636

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Abstract C142: The development of a miRNA-based therapeutic candidate for hepatocellular carcinoma

Autor: David R. Brown, Andreas G. Bader, Jane Zhao, Chris Daige, Sarah Dysart, Kevin Kelnar, Leslie Priddy

Publikováno v: Molecular Cancer Therapeutics. 10:C142-C142

Tumor suppressor miRNAs function by regulating multiple cancer-related genes and pathways. The tumor suppressor miRNAs miR-34, let-7, miR-16, miR-26, and miR-145 have proven to be effective in inhibiting tumor growth in mouse models of cancer. Based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddb3ab9bba365b448732117c7a1a9f38
https://doi.org/10.1158/1535-7163.targ-11-c142

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