Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sarah Duellman"'
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 58, Iss 8, Pp 1722-1729 (2017)
Journal of Lipid Research, Vol 58, Iss 8, Pp 1722-1729 (2017)
Monitoring the expression of cell-surface receptors, their interaction with extracellular ligands, and their fate upon ligand binding is important for understanding receptor function and developing new therapies. We describe a cell-based method that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106bc9d384c2ea5494978d0ef86e9339
https://doi.org/10.1194/jlr.d074658
https://doi.org/10.1194/jlr.d074658
Autor:
Joel R. Walker, Chad Zimprich, Jacquelynn Rodriguez, Thomas Machleidt, Mary P. Hall, Sarah Duellman, Wenhui Zhou, Matthew B. Robers
Publikováno v:
ACS Chemical Biology. 12:1028-1037
Novel engineered NanoLuc (Nluc) luciferase being smaller, brighter, and superior to traditional firefly (Fluc) or Renilla (Rluc) provides a great opportunity for the development of numerous biological, biomedical, clinical, and food and environmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73088ed34f94b50dd12f892492fd14db
https://doi.org/10.1021/acschembio.6b01129
https://doi.org/10.1021/acschembio.6b01129
Autor:
Sarah Duellman, Prson Gautam, Gediminas Vidugiris, Jolanta Vidugiriene, Wenhui Zhou, Krister Wennerberg, James J. Cali, Poncho Meisenheimer
Publikováno v:
Assay and Drug Development Technologies
Real-time continuous monitoring of cellular processes offers distinct advantages over traditional endpoint assays. A comprehensive representation of the changes occurring in live cells over the entire length of an experiment provides information abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cc0a073ab702a40992e83494525dd2
https://doi.org/10.1089/adt.2015.669
https://doi.org/10.1089/adt.2015.669
Autor:
James J. Cali, Leonard Moothart, Dieter Klaubert, Mary Sobol, John Shultz, Céline DiBernardo, Poncho Meisenheimer, Laurent Bernad, Joshua J. Kimball, Jolanta Vidugiriene, Sarah Duellman, Wenhui Zhou, Martha O'brien, Donna Leippe
Publikováno v:
ChemBioChem. 15:670-675
Highly sensitive self-cleavable trimethyl lock quinone-luciferin substrates for diaphorase were designed and synthesized to measure NAD(P)H in biological samples and monitor viable cells via NAD(P)H-dependent cellular oxidoreductase enzymes and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083df1832b0765ebc5796d4825026325
https://doi.org/10.1002/cbic.201300744
https://doi.org/10.1002/cbic.201300744
Publikováno v:
Cancer Research. 78:3901-3901
Recent clinical successes using antibody drug conjugates (ADC) directed to hematological or solid tumor cancers have re-invigorated immunotherapeutic drug development interest. Unfortunately, efficacious ADC are inherently complex entities comprised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca043464d49e889e13be312c3b5805ca
https://doi.org/10.1158/1538-7445.am2018-3901
https://doi.org/10.1158/1538-7445.am2018-3901
Publikováno v:
SpringerPlus
Induction of oxidative stress by drugs and other xenobiotics is an important mechanism of cytotoxicity. However, in vitro studies on the relationship between oxidative stress and cytotoxicity in cultured cells is frequently complicated by the fact th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3582633d4b7ca189231969c8c37489
https://doi.org/10.1186/s40064-015-1063-y
https://doi.org/10.1186/s40064-015-1063-y
Autor:
Donna Leippe, Sarah Duellman, Jolanta Vidugiriene, Mary Sobol, Mike Valley, Natasha Karassina, James J. Cali
Publikováno v:
Cancer Research. 76:1057-1057
Cellular energy metabolism is recognized to have a central role in many cell processes and is an increasingly important area of study in many research fields such as cancer, immunology, obesity, diabetes and neurology. To facilitate these studies, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04454ebd6ea0a621a23b85eb9076b6cf
https://doi.org/10.1158/1538-7445.am2016-1057
https://doi.org/10.1158/1538-7445.am2016-1057
Autor:
James J. Cali, Jolanta Vidugiriene, Donna Leippe, Mike Valley, Sarah Duellman, Mary Sobol, Natasha Karassina
Publikováno v:
Molecular Cancer Research. 14:B49-B49
We describe a set of bioluminescence assays for systematic evaluation of metabolic alterations in response to different growth conditions or treatments. These newly developed cell-based bioluminescence assays offer new methods to detect different met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1104f155aa8e0e08e269aa558c704ea3
https://doi.org/10.1158/1557-3125.metca15-b49
https://doi.org/10.1158/1557-3125.metca15-b49
Autor:
Wenhui Zhou, Vinayaka Kotraiah, Jean Osterman, Joshua J. Kimball, Poncho Meisenheimer, Jolanta Vidugiriene, James J. Cali, Michael P. Valley, Laurent Bernad, Sarah Duellman
Publikováno v:
Analytical biochemistry. 434(2)
The aldehyde dehydrogenase (ALDH) family of enzymes is critical for cell survival and adaptation to cellular and environmental stress. These enzymes are of interest as therapeutic targets and as biomarkers of stem cells. This article describes a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a55a15809bee9e9d5311d09c131a51
https://pubmed.ncbi.nlm.nih.gov/23219557
https://pubmed.ncbi.nlm.nih.gov/23219557
Autor:
Jolanta Vidugiriene, Wenhui Zhou, Laurent Bernad, Poncho Meisenheimer, Ruslan Arbit, Sarah Duellman, Jean Osterman, James J. Cali
Publikováno v:
Cancer Research. 74:3743-3743
Cell-based assay development for cancer drug discovery continues to advance toward more innovative methods that provide efficient workflow and meaningful data. Rapid, sensitive techniques that are non-lytic and therefore facilitate multiplexing with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86ea4ea1c20bb8ead0a91f1fc657aad
https://doi.org/10.1158/1538-7445.am2014-3743
https://doi.org/10.1158/1538-7445.am2014-3743