Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sarah D. Atkinson"'
Autor:
Chelsey Doyle, Breedge Callaghan, Anton W. Roodnat, Lee Armstrong, Karen Lester, David A. Simpson, Sarah D. Atkinson, Carl Sheridan, Declan J. McKenna, Colin E. Willoughby
Publikováno v:
Cells, Vol 13, Iss 12, p 1060 (2024)
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy with a complex, multifactorial aetiology. Raised intraocular pressure (IOP) is the most important clinically modifiable risk factor for POAG. All current pharmacological agents targ
Externí odkaz:
https://doaj.org/article/1c09fcdb673a4b6e99c2ab2666f7101c
Autor:
Anton W. Roodnat, Breedge Callaghan, Chelsey Doyle, Megan Henry, Katarzyna Goljanek-Whysall, David A. Simpson, Carl Sheridan, Sarah D. Atkinson, Colin E. Willoughby
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1693 (2022)
Pseudoexfoliation glaucoma (XFG) is an aggressive form of secondary open angle glaucoma, characterised by the production of exfoliation material and is estimated to affect 30 million people worldwide. Activation of the TGF-β pathway by TGF-β1 has b
Externí odkaz:
https://doaj.org/article/2f7290ed93f54f71b3e146662ec69552
Autor:
Davide Schiroli, María J. Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura Mairs, Kathleen A. Christie, Diego F. Cobice, Cian M. McCrudden, M. Andrew Nesbit, Isabel Haro, Tara Moore
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 891-906 (2019)
Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a freq
Externí odkaz:
https://doaj.org/article/37a40799393b446e910c2cb79f80cc7c
Autor:
Sophie Coyle, Mohammed Naeem Khan, Melody Chemaly, Breedge Callaghan, Chelsey Doyle, Colin E. Willoughby, Sarah D. Atkinson, Meredith Gregory-Ksander, Victoria McGilligan
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1239 (2021)
Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major
Externí odkaz:
https://doaj.org/article/6d9de80553534feda82137237c6d2c3b
Autor:
Bryan, Dirks, Maurizio, Fava, Sarah D, Atkinson, Mark, Joyce, Michael E, Thase, Becky, Howell, Tim, Lin, Serge, Stankovic
Publikováno v:
Psychopharmacology bulletin. 52(4)
In a phase 2 study, pimavanserin demonstrated efficacy as adjunctive treatment for major depressive disorder (MDD). Subsequently, two phase 3 studies (NCT03968159 in the US; NCT03999918 in Europe) were initiated to examine the efficacy and safety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::048b1d6b2f7094b08a58f9189f1f1b39
https://pubmed.ncbi.nlm.nih.gov/36339271
https://pubmed.ncbi.nlm.nih.gov/36339271
Autor:
Donald L. Gilbert, Jordan S. Dubow, Timothy M. Cunniff, Stephen P. Wanaski, Sarah D. Atkinson, Atul R. Mahableshwarkar
Publikováno v:
Pediatrics. 151
BACKGROUND AND OBJECTIVES All US Food and Drug Administration-approved medications for Tourette syndrome are antipsychotics, and their use is limited by the risk of weight gain, metabolic changes, and drug-induced movement disorders. Several small tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::045fdcf46ccb326b5147a0774b2d1092
https://doi.org/10.1542/peds.2022-059574
https://doi.org/10.1542/peds.2022-059574
Publikováno v:
Reviews in Endocrine and Metabolic Disorders. 23:449-462
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. TWEAK control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8bc2eb7703982d477318f09f8bc4ff
https://doi.org/10.1007/s11154-021-09688-4
https://doi.org/10.1007/s11154-021-09688-4
Publikováno v:
Reviews in endocrinemetabolic disorders. 23(3)
TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. TWEAK control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f32b49fc504f22693b71a434a025d4e
https://pubmed.ncbi.nlm.nih.gov/34542797
https://pubmed.ncbi.nlm.nih.gov/34542797
Publikováno v:
Journal of molecular endocrinology. 67(4)
TNFAIP3 encodes a zinc finger protein called A20, which has potent anti-inflammatory and anti-apoptotic properties. A20 promotes beta-cell survival and protects against islet graft rejection in experimental models. The current study sought to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad235228f4a91c33fc15c55b02d932d
https://pubmed.ncbi.nlm.nih.gov/34463643
https://pubmed.ncbi.nlm.nih.gov/34463643
Publikováno v:
Diabetes. 70
GWAS studies have identified a number of SNPs connected to the development of type 1 diabetes (T1D). It is unclear how these variants confer risk for T1D development and whether this is based on direct effects on the beta cell, or whether the systemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328a6d0154b8ab6759a56ddb6336377e
https://doi.org/10.2337/db21-248-or
https://doi.org/10.2337/db21-248-or