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Akademický článek

Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH

Autor: Deqiang Zhang, Yuee Zhao, Gary Zhang, Daniel Lank, Sarah Cooke, Sujuan Wang, Alli Nuotio-Antar, Xin Tong, Lei Yin

Publikováno v: Molecular Metabolism, Vol 85, Iss , Pp 101957- (2024)

Objectives: Compromised hepatic fatty acid oxidation (FAO) has been observed in human MASH patients and animal models of MASLD/MASH. It remains poorly understood how and when the hepatic FAO pathway is suppressed during the progression of MASLD towar

Externí odkaz: https://doaj.org/article/238fe995bb784466a22f4e4cd8aa092e

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Akademický článek

Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans

Autor: Daniel C.J. Ferguson, Juraidah Haji Mokim, Marjolein Meinders, Edmund R.R. Moody, Tom A. Williams, Sarah Cooke, Kongtana Trakarnsanga, Deborah E. Daniels, Ivan Ferrer-Vicens, Deborah Shoemark, Chartsiam Tipgomut, Katherine A. Macinnes, Marieangela C. Wilson, Belinda K. Singleton, Jan Frayne

Publikováno v: Haematologica, Vol 106, Iss 11 (2020)

Human ZNF648 is a novel poly C-terminal C2H2 zinc finger (ZnF) protein identified amongst the most dysregulated proteins in erythroid cells differentiated from induced pluripotent stem cells. Its nuclear localization and structure indicate it is like

Externí odkaz: https://doaj.org/article/74d92bd41183494184a640381d6306d2

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The Impact of Design Thinking and Steam Learning on Student Engagement

Autor: Sarah Cooke

Publikováno v: He Rourou. 2:109-125

Global opportunities in steam-related employment have contributed to the need for students to engage in developing skills of critical thinking, collaboration and problem solving. This need aligns well with Design Thinking, where students are encourag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2173029809db6937dbec813b7a8af245
https://doi.org/10.54474/herourou.v2i1.7153

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(Im)patient Narratives: Peer-to-Peer Health Information Transfer in the LGBTQ+ Community via Zines from the Queer Zine Archive Project (QZAP)

Autor: Sarah Cooke, Joyce M. Latham

This project examines how queer and trans zines have complicated the notion of traditional patient narratives and provides insight into the issues that LGBTQ+ (lesbian, gay, bisexual, transgender, queer/questioning) populations face when accessing he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfcc0b97bb26e1b3b33d2c5b5eb35b9c
https://doi.org/10.1108/s0065-283020200000047012

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Cerebral Oximetry During Cardiac Arrest

Publikováno v: Critical Care Medicine. 44:1663-1674

OBJECTIVES\ud Cardiac arrest is associated with morbidity and mortality because of cerebral ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation during resuscitation is associated with improved return of spontaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08cdaed43435d2d5d97af84aed929836
https://doi.org/10.1097/ccm.0000000000001723

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Lay and Professional Understandings of Research and Clinical Activities in Cancer Genetics and Their Implications for Informed Consent

Autor: Sarah Cooke, Anneke Lucassen, Sarah Parry, Michael W. Parker, Nina Hallowell, Gill Crawford

Publikováno v: AJOB Primary Research. 1:25-34

Research and clinical activities are often portrayed as arising from different motivations and having different goals. This study sought to determine lay and professional understandings of research and clinical care within the translational subspecia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fa497be2c0a3e773b3dfb6d310d00b
https://doi.org/10.1080/21507716.2010.492717

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