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Autor:
Ghazwan Butrous, Nigel Brayshaw, Ranji Thomas, K. Kamalvand, Jane Fisher, Richard Heppell, Sarah Cluck, Claire Gilbert
Publikováno v:
BMC Pharmacology. 7(Suppl 1):P59
Introduction Sildenafil inhibits phosphodiesterases type 5, an enzyme that metabolizes cGMP. It is approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Early clinical studies showed a beneficial effect in endothelia